Frequent detection but lack of infectivity of SARS-CoV-2 RNA in presymptomatic, infected blood donor plasmaArticle Published on 2022-09-012022-11-15 Journal: The Journal of Clinical Investigation [Category] SARS, 치료기술, [키워드] Blood blood donor cell line clinical Clinical practice cough COVID-19 COVID-19 mortality COVID-19 patient detectable detection Diagnosis diagnosis of COVID-19 Donor General population implementation Infectious virus Influenza information lack less Limits of detection mice Mild Molecular diagnosis Pathogenesis PDI peaked plaque-forming unit plasma presymptomatic produced question raise reported respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA severe symptoms Shortness of breath susceptible Symptom tested unlikely vaccination virus widespread [DOI] 10.1172/JCI159876 PMC 바로가기
SARS-CoV-2 and post-donation information: a one-year experience of the French haemovigilance networkArticle Published on 2022-09-012022-11-15 Journal: Blood transfusion = Trasfusione del sangue [Category] SARS, 치료기술, [키워드] antigenic applied Blood blood donor COVID-19 symptom Culture deep sequencing demographic data Diagnosis Donor donors Duration elapsed Evidence experiment fraction French highlight Hypothesis information investigated material molecular MOST nasopharyngeal no difference parameter Paris PCR test PDI plasma plasmas positive questionnaire Region reported Repository RNA RNA sequencing SARS-CoV-2 SARS-CoV-2 RNA screened Sequencing Support Symptom tested Vero E6 cell Viral transmission Virological virus isolation was collected was determined [DOI] 10.2450/2022.0266-21 PMC 바로가기
Characterization and Utilization of Disulfide-Bonded SARS-CoV-2 Receptor Binding Domain of Spike Protein Synthesized by Wheat Germ Cell-Free Production System밀 배아 무세포 생산 시스템에 의해 합성된 스파이크 단백질의 이황화 결합 SARS-CoV-2 수용체 결합 도메인의 특성화 및 활용Article Published on 2022-07-012022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 receptor Analysis bind cell-free protein synthesis characterization contribute COVID-19 COVID-19 therapeutics Disulfide disulfide bond Drug screening Endoplasmic reticulum evaluate Express functional Germ immunogenicity Interaction Mutation PDI Production Protein protein disulfide isomerase protein synthesis Rapid RBD RBD protein RBD-ACE2 SARS-CoV-2 SARS-CoV-2 SP spike Spike protein System translational utilization Vaccine viral infection Viral variants wheat [DOI] 10.3390/v14071461 PMC 바로가기 [Article Type] Article
Photodynamic Inactivation of SARS-CoV-2 Infectivity and Antiviral Treatment Effects In VitroSARS-CoV-2 감염의 광역학적 비활성화 및 시험관 내 항바이러스 치료 효과Article Published on 2022-06-142022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antibody Antiviral Antiviral agents approach Cell cell cultures cell viability Concentration coronavirus Coronavirus-2 COVID-19 Critical Culture current death detectable Effect heat-inactivated in vivo inactivation Infection infectiousness Infectivity log measure Microscopy mitochondrial Mutation near-infrared light pandemic Pathogens PDI photodynamic inactivation photodynamic therapy photosensitizer Potential treatment qPCR reduce reduced reduction required SARS SARS-CoV-2 SARS-CoV-2 isolate severe acute respiratory syndrome Coronavirus severe disease significantly THPTS Toxicity Treatment uninfected Vaccines variety Vero Cell viability viral cytopathic effect viral infection viral infections Viral load Viral RNA virion virus virus load virus suspension viruses were assessed [DOI] 10.3390/v14061301 PMC 바로가기 [Article Type] Article
An index of access to essential infrastructure to identify where physical distancing is impossible물리적 거리두기가 불가능한 곳을 식별하기 위한 필수 인프라에 대한 액세스 지수Article Published on 2022-06-142022-09-11 Journal: Nature Communications [Category] 치료법, 치료제, [키워드] addition communicable disease communicable diseases correlated country COVID-19 cases develop disease transmission Effectiveness health systems heterogeneity High-resolution highest highlight Households identify Infectious disease lack missing PDI physical distancing population density Prevent Region Regulation resource risk Space Spread Transmission water [DOI] 10.1038/s41467-022-30812-8 PMC 바로가기 [Article Type] Article
Photodynamic disinfection of SARS-CoV-2 clinical samples using a methylene blue formulationArticle Published on 2022-06-012022-10-04 Journal: Photochemical & photobiological sciences : Official journal of the European [Category] COVID19(2023년), SARS, 신약개발, [키워드] amplification amplitude antimicrobial Antimicrobial photodynamic disinfection approved clinical sample Clinical use collected Concentration condition coronavirus disease COVID-19 COVID-19 patients cytotoxicity early stage exhibiting form global effort HEK293T cells infect Infection lentiviral luciferase reporter gene medical need Medicines Methylene Methylene blue nasal pandemic PDI photodisinfection photodynamic inactivation prevented pseudotyped Pseudotyped lentiviral vector reduce SARS-CoV-2 severity the disease the S protein Transmission Treatment urgency Viral load [DOI] 10.1007/s43630-022-00202-6 PMC 바로가기 [Article Type] Article
Implementation of a Psychiatric Consultation for Healthcare Workers during First Wave of COVID-19 OutbreakCOVID-19 발생의 첫 번째 물결 동안 의료 종사자를 위한 정신과 상담 실시Article Published on 2022-04-142022-09-11 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition Analysis anxiety symptoms Burnout Clinical data Complication concerning consultation COVID-19 COVID-19 outbreak COVID-19 pandemic distress Early detection effort Emotional exhaustion First wave HADS HCW healthcare healthcare worker Healthcare workers limitation management MBI-HSS Mental overload PDI performed Post Traumatic Stress Disorder (PTSD) post-hoc Prevent prevention preventive measure Psychiatric psychiatric consultation psychiatric disorder Psychiatric disorders PTSD qualitative analysis Quantitative analysis Reactions retrospective risk severe depression socio-demographic Stress stressors Symptoms Wave worker [DOI] 10.3390/ijerph19084780 PMC 바로가기 [Article Type] Article
Evaluation of methylene blue based photodynamic inactivation (PDI) against intracellular B-CoV and SARS-CoV2 viruses under different light sources in vitro as a basis for new local treatment strategies in the early phase of a Covid19 infectionCovid19 감염 초기 단계의 새로운 국소 치료 전략의 기초로서 시험관 내 다양한 광원에서 세포 내 B-CoV 및 SARS-CoV2 바이러스에 대한 메틸렌 블루 기반 광역학 불활화(PDI) 평가Article Published on 2022-03-012022-09-11 Journal: Photodiagnosis and photodynamic therapy [Category] SARS, 치료기술, [키워드] Antiviral aPDT (antimicrobial photodynamic therapy). approach Cell Concentration Corona viruses dark dose early phase experiment Extracellular in vitro inactivation Incubation infected cell infected cells Infection intensity Laser Local logarithmic reduction low dose Methylene Methylene blue nose and throat PDI PDI (photodynamic inactivation) phenothiazine Phenothiazine dye in aPDT photodynamic inactivation photodynamic therapy photosensitizer Prognosis radiation intensity reducing reduction SARS-CoV-2 SARS-CoV-2 inactivation SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV2 sensitizer substitute therapy treated treatment strategy Vero E6 Viral load virus was reduced [DOI] 10.1016/j.pdpdt.2021.102642 PMC 바로가기 [Article Type] Article
Photodynamic Inactivation of Human CoronavirusesArticle Published on 2022-01-082022-10-28 Journal: Viruses [Category] COVID-19, [키워드] absence Antiviral antiviral activity Antiviral effect antiviral property assays Betacoronavirus concentrations coronavirus CoVs cultured cell damaged demonstrated digestion dose-dependent manner doses emodin expand experiments HCoV-229E HCoV-OC43 herpes simplex Human human cells human coronavirus inactivation inhibited lentivirus Local microorganisms natural product oxygen PDI photodynamic inactivation photosensitizer PhytoQuin prevented Protein pseudotyped reactive oxygen specy Replication RNase ROS S protein SARS-CoV-2 spike susceptible the SARS-CoV-2 Viral RNA virus viruses [DOI] 10.3390/v14010110 PMC 바로가기 [Article Type] Article
Pain experience and social support of endometriosis patients during the COVID-19 pandemic in Germany – results of a web-based cross-sectional surveyResearch Article Published on 2021-08-252022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] 5-point Likert scale activated affected asked Care characterized COVID-19 pandemic COVID-19 virus cross-sectional survey difference emotional Endometriosis Europe Factor Frequency Germany Government groups Health highest impacted impairment implementation induce Infection intensity less lockdown measure negatively affected Pain pandemic participant Patient patients PDI physical platform Prevent quarantine question questionnaire reported Result rising significantly Social distancing measure social distancing measures social isolation Spread Support Symptom the SARS-CoV-2 virus Visual Analogue Scale was reduced were assessed women worsening [DOI] 10.1371/journal.pone.0256433 PMC 바로가기 [Article Type] Research Article