Health Recommendation System using Deep Learning-based Collaborative FilteringResearch Article Published on 2023-11-242024-09-05 Journal: Heliyon [Category] update2024, [키워드] CNN collaborative filtering deep learning Health Recommendation system RBM Recommendation system [DOI] 10.1016/j.heliyon.2023.e22844 PMC 바로가기 [Article Type] Research Article
Novel Affibody Molecules Specifically Bind to SARS-CoV-2 Spike Protein and Efficiently Neutralize Delta and Omicron VariantsArticle Published on 2023-02-142023-07-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), [키워드] affibody FP fusion peptide neutralization RBM receptor binding motif S protein SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 SPR [DOI] 10.1128/spectrum.03562-22 PMC 바로가기
Omicron (BA.1) and sub-variants (BA.1.1, BA.2, and BA.3) of SARS-CoV-2 spike infectivity and pathogenicity: A comparative sequence and structural-based computational assessmentSARS-CoV-2 스파이크 감염성 및 병원성의 오미크론(BA.1) 및 하위 변이체(BA.1.1, BA.2 및 BA.3): 비교 시퀀스 및 구조 기반 계산 평가Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 binding acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin BA.1 BA.2 BA.3 BA1.1 bind binding affinity bronchial cells computational tool computational tools contribute contributing to coronavirus COVID-19 Deleterious domain Effectiveness electrostatic expressed Factor hACE2 higher affinity human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hydrogen hydrogen bonds indicate Interaction K417N less lineages Lower respiratory tract lung mutated Mutation mutations N-terminal domain N501Y negative NTD omicron Omicron variant pathogenicity positive predicted Q498 RBD RBM receptor receptors residue residues Salt Bridge SARS-CoV-2 SARS-CoV-2 spike sequence severe acute respiratory syndrome Coronavirus significantly Spike protein Spread surface potential T478K the RBD the spike protein thought Transmission transmission potential variant variants wild-type [DOI] 10.1002/jmv.27927 PMC 바로가기 [Article Type] Article
Structure-selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern구조 선택 RBM 면역원은 우려되는 SARS-CoV-2 변이체를 중화하는 다클론성 기억 반응을 일으킵니다.Article Published on 2022-07-212022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 Affect Amino acid amino acid residue antibody Antibody Response B.1.351 B.1.617.2 booster C57BL/6 can be used conserved COVID-19 pandemic domain effort full-length full-length spike protein immunization immunogen immunogenic immunogens Immunoglobulin majority memory response mice neutralize Neutralizing Neutralizing antibodies neutralizing antibody Plasmid polyclonal Prevent Protein Proteins purified RBD RBM receptor-binding motif Recombinant spike protein resulting SARS-CoV-2 variant sera spike Spike protein Spike proteins the antibody response Transmission Vaccine variants variants of concern virus VoC VOCs vulnerability WA1 wildtype [DOI] 10.1371/journal.ppat.1010686 PMC 바로가기 [Article Type] Article
Designing and characterization of a SARS-CoV-2 immunogen with receptor binding motif grafted on a protein scaffold: An epitope-focused vaccine approach단백질 스캐폴드에 이식된 수용체 결합 모티프가 있는 SARS-CoV-2 면역원의 설계 및 특성화: 에피토프 중심 백신 접근 방식Article Published on 2022-06-012022-09-12 Journal: International journal of biological macromolecules [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 angiotensin Antibody Response antigenic approach caused COVID-19 pandemic effective epitope healthcare immunized immunized mice Immuno-focusing induce Infectious disease interferon γ mice natural infection neutralization neutralizing antibody Non-neutralizing antibodies non-neutralizing epitope predominant Protein RBD RBM Receptor binding domain receptor binding motif robust SARS-CoV-2 SARS-COV-2 infection Scaffold sera Spread T cell T cell response the antibody response the disease the spike protein Vaccine [DOI] 10.1016/j.ijbiomac.2022.04.148 PMC 바로가기 [Article Type] Article
A SARS-CoV-2 Spike Receptor Binding Motif Peptide Induces Anti-Spike Antibodies in Mice andIs Recognized by COVID-19 PatientsSARS-CoV-2 스파이크 수용체 결합 모티프 펩티드는 마우스에서 스파이크 방지 항체를 유도하고 COVID-19 환자가 인식합니다Article Published on 2022-05-262022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] absence ACE2 acute respiratory syndrome Analysis angiotensin-converting enzyme 2 anti-S antibody Antigen available data benefit caused conformational coronavirus disease coronavirus SARS-CoV-2 COVID-19 COVID-19 patient domain elicit ELISA expressed Frequency Human human host cell immunized immunized animals immunized mice Infection interact Ligand means Neutralizing neutralizing Abs neutralizing function pandemic penetrate peptide peptide synthesis problems produced Protein RBD RBD domain RBM receptor Receptor binding receptor binding motif Region Research S protein SARS-CoV-2 selected spike spike (S) protein subject the antibody response the disease the S protein Treatment trimeric spike Vaccine Vaccines virus virus-neutralizing antibodies [DOI] 10.3389/fimmu.2022.879946 PMC 바로가기 [Article Type] Article
Functional reconstitution of the MERS CoV receptor binding motifMERS CoV 수용체 결합 모티프의 기능적 재구성Article Published on 2022-05-012022-09-11 Journal: Molecular immunology [Category] COVID19(2023년), SARS, 변종, [키워드] 229E beta-coronaviruses catastrophic caused Co-infection Combinatorial phage display common cold coronavirus Coronaviruses CoV COVID-19 develop disease Diseases epitope Epitope reconstitution Epitope-based vaccine etiologic agent event Evolution Fatality rate followed by Human human coronavirus human-to-human transmission Implementing incidence independent Isolation less life-threatening MERS MERS CoV. Middle East neutralizing monoclonal antibodies OC43 omicron Omicron variants pandemic Population Prevalence Protein RBM receptor binding motif Recombination reported Respiratory disease respiratory diseases SARS CoV Saudi Arabia Seven shown spike Spike protein subsequent summer variants of concern viruses [DOI] 10.1016/j.molimm.2022.03.006 PMC 바로가기 [Article Type] Article
A SARS-CoV-2 antibody retains potent neutralization against Omicron by targeting conserved RBM residuesSARS-CoV-2 항체는 보존된 RBM 잔기를 표적으로 하여 Omicron에 대한 강력한 중화를 유지합니다Article Published on 2022-05-012022-09-12 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] conserved neutralization omicron RBM residue SARS-CoV-2 antibody [DOI] 10.1038/s41423-022-00853-6 PMC 바로가기 [Article Type] Article
Healthy humans can be a source of antibodies countering COVID-19건강한 사람은 COVID-19에 대항하는 항체의 원천이 될 수 있습니다Article Published on 2022-05-012022-09-11 Journal: Bioengineered [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] ACE2 ACE2 competitor Analysis angiotensin angiotensin-converting enzyme 2 antibody antibody cocktail approach authentic SARS-CoV-2 virus best binding binding affinity Blood bypassing can be used characterized Combination COVID-19 COVID-19 diagnostics COVID-19 therapeutics detect detecting antibody diagnostic eight ELISA epitope Epitopes Evidence Evolution flow cytometry fluorescence microscopy healthy donor healthy donors Human humanized IgG immune in vitro infected patients Infection inhibit SARS-CoV-2 Isolation mice monoclonal antibodies naïve neutralization titers neutralize neutralizing antibody RBM receptor Receptor binding domain receptor-binding motif recognize SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus single B cell single-chain antibody specificity Spike protein SPR tested therapeutic unique virus infection yeast [DOI] 10.1080/21655979.2022.2076390 PMC 바로가기 [Article Type] Article
Seroreactivity of the Severe Acute Respiratory Syndrome Coronavirus 2 Recombinant S Protein, Receptor-Binding Domain, and Its Receptor-Binding Motif in COVID-19 Patients and Their Cross-Reactivity With Pre-COVID-19 Samples From Malaria-Endemic AreasCOVID-19 환자에서 중증 급성 호흡기 증후군 코로나바이러스 2 재조합 S 단백질, 수용체 결합 도메인 및 이의 수용체 결합 모티브의 혈청반응성과 말라리아 발병 지역의 코로나19 이전 샘플과의 교차 반응성Article Published on 2022-04-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 말라리아, 진단, 치료기술, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition age anti-S antibody antibody Antibody Response Antibody responses Antigen antigens Area Asthma blood sample Blood samples Community Comorbidities conducted coronavirus coronavirus 2 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 samples cross-reactive antibody cross-reactivity determine diabete diabetes disease Donor ELISA full-length Gender hospital IgG antibodies IgG antibody individual malaria malaria endemic-area participant Patient Plasmodium falciparum Plasmodium falciparum infection Pre-COVID-19 samples Protein RBD RBM Receptor-binding domain receptor-binding motif Recognition Recombinant S regions respiratory response responses S protein Sample SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 S SARS-CoV-2 S protein sera seroreactivity severe acute respiratory syndrome Coronavirus Study participants tested the receptor-binding domain the SARS-CoV-2 Treatment triggered weakened West while [DOI] 10.3389/fimmu.2022.856033 PMC 바로가기 [Article Type] Article