Two genetic variants in the SRD5A2 gene are found to be associated with sex differences in the disease characteristics of patients with chronic hepatitis B virus infectionarticle Published on 2023-10-032024-09-05 Journal: Biol Sex Differ [Category] update2024, [키워드] Chronic HBV infection Hepatitis B virus Sex difference sex hormone Sex hormone receptor Single nucleotide polymorphism SRD5A2 [DOI] 10.1186/s13293-023-00553-4 PMC 바로가기 [Article Type] article
Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasterideArticle Published on 2020-10-272022-10-04 Journal: Nature Communications [Category] 변종, 신약개발, [키워드] accompanied Analysis binding catalyzed clinically conformational Critical cytosolic deficiency Dihydrotestosterone disease-causing mutation drug drugs targeting Effects enzyme Enzyme mechanisms eukaryotic facilitate Finasteride Human information inhibitors lack mapping mechanism membrane metabolic pathways metabolism molecular dynamics molecular mechanism Mutagenesis NADPH offer Prostate Prostate cancer Reductase reduction regulate residue SRD5A2 Steroid hormones Structure Topology transmembrane domain unique X-ray crystallography [DOI] 10.1038/s41467-020-19249-z PMC 바로가기 [Article Type] Article