ASSOCIATION OF TNF-α, TGF-β1, AMPHIREGULIN, IL-2, AND EGFR WITH PULMONARY FIBROSIS IN COVID-19Short communication Published on 2022-10-012022-10-05 Journal: Journal of infection and public health [Category] 바이오마커, [키워드] age analyzed association blood sample chest CT scan coronavirus disease COVID-19 COVID-19 pneumonia patient Critical cytokine discharged EGFR ELISA evaluate evaluated fibrosis hospital IL-2 mechanism men Patient Pneumonia pulmonary pulmonary fibrosis Serum level severity TGF TGF-β1 the patient TNF- α TNF-α was performed women [DOI] 10.1016/j.jiph.2022.08.007 [Article Type] Short communication
Molecular Mechanisms of Alveolar Epithelial Stem Cell Senescence and Senescence-Associated Differentiation Disorders in Pulmonary Fibrosis폐 섬유증에서 폐포 상피 줄기 세포 노화 및 노화 관련 분화 장애의 분자 기전Review Published on 2022-03-032022-09-11 Journal: Cells [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] accelerated alveolar caused Cell cell senescence cellular senescence COVID-19 Degradation developmental differentiation disorder disrupt DNA damage DNA damage response dysfunction epithelial fibrosis followed by framework Idiopathic pulmonary fibrosis induce inhibiting inhibitor Intervention IPF low-grade inflammation mechanism molecular mechanism molecular mechanisms OIS oncogene pathway Premature Protein pulmonary pulmonary fibrosis replicative replicative senescence reported reverse transcriptase RNA SARS-CoV-2 viral infection senescence senescent cell senescent cells STEM stem cell suppression susceptibility telomerase telomerase and telomeres. telomeres TERC TERT TGF TGF-β TGF-β signalling TPP1 transcriptase Viral viral infection [DOI] 10.3390/cells11050877 PMC 바로가기 [Article Type] Review
In well-differentiated primary human bronchial epithelial cells, TGF- β 1 and TGF- β 2 induce expression of furin잘 분화된 일차 인간 기관지 상피 세포에서 TGF-β1 및 TGF-β2는 푸린의 발현을 유도한다Article Published on 2021-02-012022-09-11 Journal: American journal of physiology. Lung cellular and [Category] Coronavirus, SARS, 유전자 메커니즘, [키워드] ACE2 Air-liquid interface angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 bronchial epithelial cells caused Cell cells cellular cellular differentiation cellular entry cellular mechanism cellular mechanisms Chain Reaction ciliated cells COVID-19 COVID-19 pandemic cytokine develop drug effective enzyme epithelial experimental system Express expression furin genes encoding Host immunofluorescence immunofluorescence staining in vitro include induce knowledge less Like mediators polymerase chain polymerase chain reaction protease Proteases Protein protein expression public health quantitative polymerase chain reaction receptor reported required researcher RT-qPCR Safe SARS-CoV-2 SARS-COV-2 infection Serine staining TGF TGF-β TGF-β1 the disease These data TMPRSS2 transmembrane serine protease transmembrane serine protease 2 Treatment Viral western blot [DOI] 10.1152/ajplung.00423.2020 PMC 바로가기 [Article Type] Article
Host transcriptomic profiling of COVID-19 patients with mild, moderate, and severe clinical outcomesResearch article Published on 2020-12-182022-10-05 Journal: Computational and Structural Biotechnology Journal [Category] 유전자 메커니즘, [키워드] Analysis approach cascades CCL2 CCL22 cellular pathway chemokine Clinical outcome Coagulation complement COVID-19 COVID-19 patient CXCL12 CXCL9 cytokine disease disease severity dysregulated Expression signature Gene expression analysis Host human RNA identify Ifi44 IFIH1 IFIT1 IL10 immune interferon involved Jak-STAT management Mild moderate molecular Nasopharyngeal swab nasopharyngeal swabs outcome pathophysiology Pathways Patient patients with COVID-19 predictor Prognosis receptor signaling Regulatory severe symptoms signaling pathway significantly higher TGF Transcriptome transcriptome sequencing transcriptomic [DOI] 10.1016/j.csbj.2020.12.016 [Article Type] Research article
Circulating Cytokines and Lymphocyte Subsets in Patients Who Have Recovered from COVID-19Research Article Published on 2020-11-262022-10-27 Journal: BioMed Research International [Category] COVID-19, [키워드] Alpha Analysis analyzed B cell B cells CD19 CD3 CD4 CD56 CD8 circulating Cohort Concentration consequence correlation COVID-19 COVID-19 infections cytokine decrease discharge Efficacy flow cytometry growth factor healthy controls hospital Hyperinflammatory IFN IL-10 IL-17 IL-2 IL-4 IL-6 IL-8 Immune status immune system increases in independent predictor Infection interferon gamma longitudinal study lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes Necrosis NK cell NK cells observation Patient patients positively correlated recovered recovered patient recruited rehabilitation remained ROC Curve serum significantly higher significantly lower sustained T cell T cells TGF TNF- α [DOI] 10.1155/2020/7570981 PMC 바로가기 [Article Type] Research Article
Circulating Cytokines and Lymphocyte Subsets in Patients Who Have Recovered from COVID-19Research Article Published on 2020-11-262022-10-27 Journal: BioMed Research International [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] Alpha Analysis analyzed B cell B cells CD19 CD3 CD4 CD56 CD8 circulating Cohort Concentration consequence correlation COVID-19 COVID-19 infections cytokine decrease discharge Efficacy flow cytometry growth factor healthy controls hospital Hyperinflammatory IFN IL-10 IL-17 IL-2 IL-4 IL-6 IL-8 Immune status immune system increases in independent predictor Infection interferon gamma longitudinal study lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes Necrosis NK cell NK cells observation Patient patients positively correlated recovered recovered patient recruited rehabilitation remained ROC Curve serum significantly higher significantly lower sustained T cell T cells TGF TNF- α [DOI] 10.1155/2020/7570981 PMC 바로가기 [Article Type] Research Article
nSARS-Cov-2, pulmonary edema and thrombosis: possible molecular insights using miRNA-gene circuits in regulatory networksResearch Published on 2020-10-302022-10-31 Journal: Exrna [Category] COVID-19, [키워드] accompany Antigen presentation antigen-presentation approach Cell coronavirus 2 Diseases disorder drugs edema Factor Features Feed forward loops FFLs identify Infection Inflammatory response information loop miRNA miRNA coregulatory networks molecular molecular mechanism motif nSARS-CoV-2 pandemic pathophysiology pathway pulmonary disease Pulmonary edema regulate regulatory circuit regulatory network Research respiratory Result Signaling signaling pathway signaling pathways similarity Spread symptomatic targets TGF the disease thromboembolic thrombosis trajectory unique vaccine candidate viral replication virus virus spike protein while [DOI] 10.1186/s41544-020-00057-y PMC 바로가기 [Article Type] Research
Phenotypic characterization of a pair of molecules in tissues confer to classical Mendelian or non Mendelian ratiosarticle Published on 2016-09-302024-09-01 Journal: Med Hypotheses [Category] 한센병, [키워드] Bimolecular interactions CD68 ceramide epistasis iNOS LAM leprosy nerve PGL plasma S100 skin TGF TNF [Article Type] article
Avian CD4+CD25+ regulatory T cells: Properties and therapeutic applications조류 CD4+CD25+ 조절성 T 세포: 특성 및 치료적 응용journal-article Published on 2013-11-012024-07-31 Journal: Developmental & Comparative Immunology [Category] 살모넬라증, [키워드] IL-10 Persistance Regulatory T Suppressive TGF Tregs [DOI] 10.1016/j.dci.2013.04.018 [Article Type] journal-article