A single-administration therapeutic interfering particle reduces SARS-CoV-2 viral shedding and pathogenesis in hamsters
Article
Published on
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 치료기술, 치료제,
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 치료기술, 치료제,
[키워드] acute respiratory syndrome
Administered
Antiviral effect
coronavirus
COVID-19 pandemic
delta variant
Detection limit
disease
dose
effective
Efficacy
exhibited
hamster
hamsters
highest
Infectious virus
Inflammatory cytokines
Intervention
intranasally
intrinsically
limit
Lipid nanoparticle
Lower
mucosa
nasal
Particle
Pathogenesis
Postinfection
Prevent
reduce
reduced
reported
respiratory tissue
respiratory virus
SARS-CoV-2
SARS-CoV-2 replication
SARS-CoV-2 transmission
SARS-CoV-2 viral shedding
severe disease
severe lung pathology
significantly lower
suppress
tested
therapeutic
therapeutic interfering particles
TIP
tissue
Transmissibility
Transmission
uninfected
variants
viral loads
viral replication
while
[DOI] 10.1073/pnas.2204624119 PMC 바로가기
[DOI] 10.1073/pnas.2204624119 PMC 바로가기