ULN – Communicable Diseases Research

Safety and immunogenicity of SARS-CoV-2 vaccines in Chinese patients with cirrhosis: a prospective multicenter study

중국 간경변증 환자에서 SARS-CoV-2 백신의 안전성 및 면역원성: 전향적 다기관 연구

Multicenter Study

Published on 2022-06-012022-09-12
Journal: Hepatology international
[Category] COVID19(2023년), MERS, SARS, 진단,

The prognostic value of cardiac troponin for 60 day mortality and major adverse events in COVID-19 patients

COVID-19 환자의 60일 사망률 및 주요 부작용에 대한 심장 트로포닌의 예후 가치

Article

Published on 2021-11-012022-09-11
Journal: Cardiovascular pathology : the official journal of
[Category] 바이오마커,

[키워드] adjusted Admission adverse event baseline characteristics benefit Biomarker C-reactive protein cardiac troponin Chronic kidney disease clinician Cohort Comorbidities Composite coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 infection COVID-19 patient cTn disease effort Elevation ferritin Hospitalization Illness severity In-hospital in-hospital mortality inclusion criteria Inflammation initial intensive care intensive care unit Intervention intubation Kidney disease Laboratory Lactate lactate dehydrogenase limit Logistic regression marker Mild morbidity and mortality Mortality Non-invasive non-invasive positive pressure ventilation Patient patients with COVID-19 positive pressure positive pressure ventilation predict Predictive predictor pressure ventilation Prognostic value Protein renal renal disease Retrospective study SARS-CoV-2 Severe COVID-19 Infection System troponin troponin. ULN university USA Variability was performed were excluded
[DOI] 10.1016/j.carpath.2021.107374 PMC 바로가기 [Article Type] Article

Serum amylase elevation is associated with adverse clinical outcomes in patients with coronavirus disease 2019

Research Paper

Published on 2021-10-312022-10-28
Journal: Aging (Albany NY)
[Category] COVID-19, MERS, SARS,

[키워드] Acute kidney injury acute respiratory distress all-cause mortality Analysis analyzed association characterized Chronic kidney disease Clinical outcome collected complications coronavirus disease COVID-19 COVID-19 patient COVID-19 patients creatinine cubic spline Effects elevated epidemiological Evolution greater hazard ratio hospital Hospitalization hyperamylasemia In-hospital death independent risk factor indicated Infection information Injury Intensive Intervention Laboratory limit Logistic regression logistic regression model male medical system medication Mortality Multiorgan dysfunction multivariable Older age outcome Pancreatic Injury Patient patients patients with COVID-19 Prevalence random Restricted retrospective cohort study Sepsis serum serum amylase Standard deviation syndrome systemic corticosteroids Treatment ULN variable
[DOI] 10.18632/aging.203653 PMC 바로가기 [Article Type] Research Paper

Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients

Article

Published on 2021-09-172022-10-30
Journal: Journal of Clinical Medicine
[Category] COVID-19,

[키워드] adjusted Admission adverse outcomes age albumin ALT Analysis analyzed association AST blood test center chronic liver disease clinical clinical outcomes Clinical severity Comorbidity Coronavirus disease 2019 COVID-19 COVID-19 severity death defined derangement Elevation evaluate experience Hospital admission Hospitalized hospitalized patient Impact intensive care liver liver functional tests Liver injury mechanical ventilation Mortality multivariate Cox regression obesity occurred outcome Patient patients patients hospitalized patients with COVID-19 predictor Prevalence Regional remained risk severe disease severity of COVID-19 Sex Test ULN with COVID-19
[DOI] 10.3390/jcm10184222 PMC 바로가기 [Article Type] Article

A randomized open-label trial to evaluate the efficacy and safety of triple therapy with aspirin, atorvastatin, and nicorandil in hospitalised patients with SARS Cov-2 infection: A structured summary of a study protocol for a randomized controlled trial

SARS Cov-2 감염으로 입원한 환자에서 아스피린, 아토르바스타틴, 니코란딜을 사용한 삼중 요법의 효능과 안전성을 평가하기 위한 무작위 공개 시험: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2021-07-152022-09-10
Journal: Trials
[Category] SARS, 임상,

[키워드] 1:1 ACHE Acute coronary syndrome Acute kidney injury acute renal failure adequate hydration adjuvant therapy Admission allergy ALT/AST Altered mental status Anti-inflammatory anticoagulation antipyretics Antithrombotic approved ARDS Aspirin AST/ALT atorvastatin bleeding Blinding block randomization Breastfeeding brown urine change characterized clinical clinical feature Clinical features Coagulopathy college Combination comorbid condition comorbid conditions comparator conducted control group coronary syndrome Corticosteroid Corticosteroids cough COVID-19 CPK creatine creatine kinase creatinine CRP current therapy Dexamethasone dissemination dose drug dysfunction Dyspnoea dysregulation effective Efficacy and safety element Endothelial dysfunction enrolled ethical committee evaluate excluded ferritin Fever followed by greater heparin hepatotoxicity Hospital admission hospital discharge Hospital mortality Hospital stay hospitalised patient Hospitalised patients hyperbilirubinemia hypoxia ICMR IEC immune dysregulation immunomodulatory impaired consciousness in-hospital mortality India Inflammation Inflammatory marker inflammatory markers Intervention intervention group intolerance intravenous Intravenous remdesivir invasive limit liver low molecular weight low molecular weight heparin management marker mechanical ventilation medication medications moderate muscle ache myalgia Myoglobin Myopathy myositis national guidelines Nicorandil Non-invasive number objective once daily Open-label open-label trial outcome oxygen Oxygen requirement oxygen support participant pathophysiologic pathophysiology Patient Platelet Platelet count Pneumonia positive Pregnancy Primary outcome progression protocol raised Rajendra Prasad Randomised control trial randomization randomize Randomized Randomized controlled trial randomly divided receive recruitment reducing mortality Registered registry Remdesivir renal failure reported respiratory rate rhabdomyolysis room air RT-PCR safety endpoint safety endpoints Sample size SARS-CoV-2 infected patient SARS-COV-2 infection Schematic screened Secondary outcomes Sepsis serum serum markers severe disease Shock significant interaction SpO2 Standard Standard of care starting dose statin statins Study design Study protocol substrates supplementary material Symptom Symptomatic treatment Tablet therapeutic therapeutic agent therapy thrombocytopenia Treatment Trial Trial registration two-arm parallel ULN Urine weakness website
[DOI] 10.1186/s13063-021-05361-y PMC 바로가기 [Article Type] Letter

Reconvalescent plasma/camostat mesylate in early SARS-CoV-2 Q-PCR positive high-risk individuals (RES-Q-HR): a structured summary of a study protocol for a randomized controlled trial

초기 SARS-CoV-2 Q-PCR 양성 고위험 개인(RES-Q-HR)의 회복기 혈장/카모스타트 메실레이트: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2021-05-172022-08-31
Journal: Trials
[Category] SARS, 임상, 치료기술, 치료제,

[키워드] accommodation acts Administered administration Adult patients Adverse adverse events alcohol Alcohol Abuse ALT anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody anticancer Antiviral antiviral therapy appearance approved AST blinded Blinding BMI body weight Bone marrow Breastfeeding CAD camostat Camostat mesylate Capsule Care Caregivers Cell Child chronic Chronic kidney disease chronic obstructive pulmonary disease chronic obstructive pulmonary disease (COPD) cirrhosis CKD clinical clinical condition Compliance Concomitant concurrent conducted control group Controlled trial convalescent plasma COPD Coronary artery Coronary artery disease cough COVID-19 COVID-19 pneumonia criteria cumulative defined diabetes Diabetes Mellitus diagnosed diagnosis of SARS-CoV-2 diarrhea disease Disease progression disease stage disorder dissemination double-blind Duration early disease Early phase of SARS-CoV-2 infection Efficacy element enrolled Enrollment enrolment EudraCT evaluate evening event evidence of Exanthema excluded exclusion criteria fatigue Fever fibrosis Germany GFR half-live headache high risk higher risk Hospitalization Hospitalized host cell hypersensitivity IgA deficiency immunization Inclusion inclusion criteria increased risk independent individual Infection infection with SARS-CoV-2 Influenza influenza A Informed consent inhibitor institution intervention arm intervention arms Kidney disease less Life expectancy likelihood Liver cirrhosis Local local Ethics Committee Mask mesylate moderate mother multicenter nasal nasal cannula Neutralizing number objective Obstructive obstructive pulmonary disease Older Ordinal Scale organ outcome outcomes oxygen oxygen demand Pancreatitis parallel group participant Participants passive immunization Patient patients hospitalized PCR Placebo plasma Plasma transfusion Pneumonia positive pregnant women Presence Prevent prevent disease progression primary endpoint progression protocol pulmonary disease pulmonary fibrosis Q-PCR randomization Randomized Randomized controlled trial receive recruitment reduce Regulatory reported risk factor safety monitoring committee Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR screening visit Serine serine protease TMPRSS2 Serious Adverse Event Serious Adverse Events severe COVID-19 Shortness of breath SOC sore throat Stage Standard Standard of care stratified Stress Study protocol supplementary material Symptom symptom duration Symptoms tertiary care center tested the cell titers TMPRSS2 transfusion reaction Treatment treatment arm Trial Trial registration Tumor typical symptom typical symptoms ULN virus website WHO with COVID-19 women working hypothesis written Informed Consent
[DOI] 10.1186/s13063-021-05181-0 PMC 바로가기 [Article Type] Letter

Impact and Determinants of High-Sensitivity Cardiac Troponin-T Concentration in Patients With COVID-19 Admitted to Critical Care

중환자실에 입원한 COVID-19 환자의 고감도 심장 트로포닌-T 농도의 영향 및 결정 요인

Multicenter Study

Published on 2021-05-152022-09-11
Journal: The American journal of cardiology
[Category] SARS, 바이오마커,

[키워드] Admission age APACHE Biomarker cardiac cardiac troponin Cohort cohorts Concentration consecutive patients COVID-19 Critically ill Critically ill patient critically ill patients death determinant died discharge Elevation Factors ICU Impact independent intensive care invasive ventilation Kaplan-Meier survival analysis likelihood limit London management mechanism Mortality myocardial injury on admission Patient patients hospitalized peak performed Pneumonitis Predictive predictor remained reported score severe COVID-19 significantly lower Stratification Stress survival analysis survivor troponin ULN with COVID-19
[DOI] 10.1016/j.amjcard.2021.01.037 PMC 바로가기 [Article Type] Multicenter Study

Severe liver dysfunction complicating course of COVID-19 in the critically ill: multifactorial cause or direct viral effect?

Research

Published on 2021-03-152022-10-28
Journal: Annals of Intensive Care
[Category] COVID-19,

[키워드] 95% CI admitted to ICU age analyzed caused Characteristics Cholestatic liver disease clinical Clinical characteristics Comorbidity confounders contribute coronavirus disease Course COVID-19 Critically ill Critically ill patient defined ECMO evaluated Gender had more Health high mortality Hypoxic liver injury ICU in both groups jaundice Laboratory liver dysfunction Liver injury mechanical ventilation Mortality multifactorial Occurrence outcome overlapped pandemic Patient Presence renal replacement therapy reported required Result SARS-CoV-2 severe respiratory failure severity severity of illness significantly higher supplementary material therapy ULN university hospital Viremia with COVID-19
[DOI] 10.1186/s13613-021-00835-3 PMC 바로가기 [Article Type] Research

Coagulopathy of hospitalised COVID-19: A Pragmatic Randomised Controlled Trial of Therapeutic Anticoagulation versus Standard Care as a Rapid Response to the COVID-19 Pandemic (RAPID COVID COAG – RAPID Trial): A structured summary of a study protocol for a randomised controlled trial

입원한 COVID-19의 응고병증: COVID-19 유행병에 대한 신속한 대응으로서 치료용 항응고제 대 표준 치료의 실용적인 무작위 통제 시험(RAPID COVID COAG – RAPID 실험): 무작위 통제 실험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2021-03-102022-09-10
Journal: Trials
[Category] SARS, 임상, 치료기술,

[키워드] 1:1 absence acutely ill hospitalized medical patients Admission age allergy allocation concealment allocation sequence Alpha America and protocol Anticoagulant anticoagulation antiplatelet antithrombotic therapy apixaban arterial bleeding bleeding risk Blinding block sizes blood cell Brazil can not Canada Care Chain Reaction changed choice clinical trial clinically clinician Coagulation Coagulopathy Committee complex Composite computer-generated contraindication control group Controlled COVID COVID-19 Critical Critical illness cryoprecipitate D-dimer D-dimer value Dabigatran dalteparin Date death defined dependent on detect determine diagnosis of SARS-CoV-2 diagnostic Diagnostic imaging discretion disorder dissemination dose dual edoxaban electrocardiogram element elevated emergency room enoxaparin Enrollment evaluated exclusion criteria expected experimental group fibrinogen fondaparinux frozen plasma Health Organization hemoglobin heparin heparin-induced thrombocytopenia High dose high risk hospital Hospital admission hospitalised Hospitalized hospitalized patient hospitalized patients ICU ICU admission include inclusion criteria indicated individual inflammatory biomarkers Informed consent INR intensive care intensive care unit Interactive Web Response System intermediate dose Invasive mechanical ventilation involved Ireland isothermal amplification judgement limit LMWH Local low molecular weight low molecular weight heparin Major major bleeding mechanical ventilation Non-invasive non-invasive positive pressure ventilation nucleic acid number objective occur Open-label open-label trial outcome oxygen oxygen saturation participant Patient patients Phase 3 plasma Platelet Platelet count Platelets polymerase chain polymerase chain reaction positive pressure positive pressure ventilation power Pregnancy pressure ventilation protocol random random allocation randomised randomised controlled trial randomization Randomized controlled trial Rapid recruited red blood cell renal replacement therapy replacement therapy response responsible reverse transcriptase Reverse transcriptase polymerase chain reaction risk risk difference rivaroxaban room air Sample size Saudi Arabia secondary Secondary outcomes Standard standard care status stratified study population Study protocol supplementary material symptomatic the patient the United State therapeutic anticoagulation therapeutic dose therapy thrombocytopenia Thromboembolism Thromboprophylaxis tinzaparin transcriptase transfusion treated Trial Trial registration two-sided ULN unfractionated heparin United Arab Emirates United States Venous Thromboembolism Ventilator-free days Version Warfarin website World Health Organization
[DOI] 10.1186/s13063-021-05076-0 PMC 바로가기 [Article Type] Letter

Development and validation of a predictive model of in-hospital mortality in COVID-19 patients

Research Article

Published on 2021-03-042022-10-28
Journal: PLoS ONE
[Category] COVID-19, MERS, SARS,

[키워드] age aPTT Arterial hypertension AUC calibrated Coagulopathy Cohort COVID-19 patient D-dimer D-dimer level death demographic data development Diabetes Mellitus evaluate evaluated Factor fibrinogen Gender hospital hospitalized COVID-19 patient in-hospital mortality independent laboratory parameter Lymphocyte count male marker multivariable analysis multivariate logistic regression Negative predictive value obesity outcome parameter performed Platelet Positive predictive value positively correlated predict Predictive pulmonary diseases renal risk factor Serum ferritin smoking specificity ULN was tested
[DOI] 10.1371/journal.pone.0247676 PMC 바로가기 [Article Type] Research Article