A570D – Communicable Diseases Research

Naturally occurring spike mutations influence the infectivity and immunogenicity of SARS-CoV-2

Article

Published on 2022-11-012022-11-15
Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 변종, 진단,

Mutational dynamics across VOCs in International travellers and Community transmission underscores importance of Spike-ACE2 interaction

국제 여행자의 VOC와 지역 사회 전파에 걸친 돌연변이 역학은 Spike-ACE2 상호 작용의 중요성을 강조합니다.

Article

Published on 2022-09-012022-09-11
Journal: Microbiological research [Category] COVID19(2023년), SARS, 변종,

[키워드] A570D Alpha analysed B.1.617.2 binding binding affinity change Community community transmission comparable COVID-19 case COVID-19 pandemic D1118H D950N Delta demonstrated different time point different time points disequilibrium early phase emergence Evolution functional G142D Genomic surveillance India Interaction International investigated L452R Lineage linkage Linkage disequilibrium Mutation mutation analysis mutations N501Y notable omicron ORF1 ORF1ab overlap predict raised S982A SARS-CoV-2 selective spike spike mutations spike-ACE2 Spread Structural analysis Transmissibility Transmission transmission pattern unique vaccination variants variants of concern VoC VOCs
[DOI] 10.1016/j.micres.2022.127099 PMC 바로가기 [Article Type] Article

Deep learning based on biologically interpretable genome representation predicts two types of human adaptation of SARS-CoV-2 variants

생물학적으로 해석 가능한 게놈 표현에 기반한 딥 러닝은 SARS-CoV-2 변이체의 두 가지 유형의 인간 적응을 예측합니다

Article

Published on 2022-05-132022-09-11
Journal: Briefings in Bioinformatics [Category] COVID19(2023년), SARS, 변종, 치료법,

[키워드] 3D convolutional neural networks A570D adaptation adaptive Alpha VOC Analysis applied Beta biological significance CNN Convolutional neural network coronavirus COVID-19 CoVs D1118H DCR deep Delta determinant dinucleotide dinucleotide composition representation distribution DNT dominant feature framework genetic diversity Genome glycoprotein human adaptation introduced linear Local Mutation omicron opposite pathogenicity performed predict predicted RdRP RdRps real time RNA virus RNA viruses RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants single-stranded Spike proteins ssRNA the spike protein Transmissibility Type variant variants variants of concern variants of interest viruses VOCs
[DOI] 10.1093/bib/bbac036 PMC 바로가기 [Article Type] Article

SARS-CoV-2 infection after vaccination in Italian health care workers: a case report

Short Communication

Published on 2022-03-062022-10-30
Journal: National Academy Science Letters. National Academy of Sciences, India [Category] COVID-19,

Haplotype distribution of SARS-CoV-2 variants in low and high vaccination rate countries during ongoing global COVID-19 pandemic in early 2021

2021년 초 글로벌 COVID-19 대유행이 진행되는 동안 백신 접종률이 낮거나 높은 국가에서 SARS-CoV-2 변이체의 일배체형 분포

Article

Published on 2022-01-012022-09-11
Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 유전자 메커니즘,

[키워드] A222V A570D acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis Canada characterized Complete coronavirus country COVID-19 outbreak COVID-19 pandemic COVID19 D614G distribution dominant effort Epitopes evade furin furin cleavage site genome sequence Germany group Haplotype haplotypes help Impact India indicated L452R Malaysia maximum Mutation N501Y neutralization new SARS-CoV-2 Nsp12 Ongoing pandemic P323L P681H pandemic Partly vaccinated rate pathogenic profile profiles Profiling Protein proteome proteomes public health Research response to vaccination S982A SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein T19R T478K T716I Taiwan Transmissibility vaccination vaccination rate Vaccination strategies Vaccine-induced immunity variant viral mutation Viral mutations widespread
[DOI] 10.1016/j.meegid.2021.105164 PMC 바로가기 [Article Type] Article

Distant residues modulate conformational opening in SARS-CoV-2 spike protein

SARS-CoV-2 스파이크 단백질의 구조적 개방을 조절하는 먼 잔류물

408

Published on 2021-10-262022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 변종,

[키워드] A570D ACE2 receptor ACE2 receptors acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 all-atom molecular dynamics simulations Analysis antibody applied attachment binding conformational conformational change conserved contagious coronavirus correlation correlations COVID-19 D614G mutation Data analysis Distant drug drug design drug resistance effort Epidemics event focus Health crisis host cells hotspot identify implication independent independent component analysis Infection initiated involved membrane modulate molecular molecular biophysics molecular dynamics Molecular dynamics simulation monoclonal antibodies monoclonal antibody multiple coronaviruses mutant Mutation mutations new strain Novel coronavirus Outbreaks pandemic predicted Protein public health crisis RBD RBD region receptor Receptor-binding domain Region residue residues respiratory SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus Significance Significant Spike protein Spike proteins statistical mechanics the RBD the receptor-binding domain the spike protein therapeutic Therapeutics Transmissibility treat Vaccine virulence virus structure
[DOI] 10.1073/pnas.2100943118 PMC 바로가기 [Article Type] 408

Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function

Research

Published on 2021-08-122022-10-05
Journal: Nature Structural & Molecular Biology [Category] SARS, 변종,

Molecular Epidemiology of SARS-CoV-2 in Diverse Environmental Samples Globally

Article

Published on 2021-08-102022-10-29
Journal: Microorganisms [Category] COVID-19,

[키워드] A570D acute respiratory syndrome Alpha Alpha variant amino acid substitution Analysis analyzed B.1 B.1.1 B.1.1.7 China circulating Community Contamination coronavirus country COVID-19 COVID-19 case Czech Republic D614G detect Epidemiology Genetic genomic Germany GISAID highest Human Italy Lineage Mutation Netherlands Other Outbreaks P681H pandemic percentage Phylogenetic analysis prevalent lineage Prevent recorded reported S982A Sample SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 virus sequence sewage Slovenia Spike protein strain Surveillance Switzerland T716I Treatment variant virus genome wastewater
[DOI] 10.3390/microorganisms9081696 PMC 바로가기 [Article Type] Article

A Sanger-based approach for scaling up screening of SARS-CoV-2 variants of interest and concern

관심 및 우려의 SARS-CoV-2 변종에 대한 스크리닝을 확대하기 위한 Sanger 기반 접근 방식

Article

Published on 2021-08-012022-09-11
Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종,

A Comprehensive Molecular Epidemiological Analysis of SARS-CoV-2 Infection in Cyprus from April 2020 to January 2021: Evidence of a Highly Polyphyletic and Evolving Epidemic

2020 년 4 월부터 2021 년 1 월까지 키프로스에서 SARS-COV-2 감염에 대한 포괄적 인 분자 역학 분석 : 고도로 다발성 및 진화 전염병의 증거

Article

Published on 2021-06-092022-09-10
Journal: Viruses [Category] MERS, SARS, 변종, 유전자 메커니즘,

[키워드] A222V A570D acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adopted affected analyses Analysis antibody Asia B.1 B.1.1.7 B.1.177 Brazil characterized clinical sample clinical samples Comprehensive concern coronavirus COVID-19 Cyprus Czech Republic D1118H D614G Denmark diagnostic diagnostic testing Epidemic epidemiological Europe European evidence of Genetic genetic analysis Germany global public health Health crisis hospitalized patients immune evasion indicated Infection initial island Italy L18F limit Lineage lineages lockdown majority measure molecular Molecular epidemiology Mutation N439K N501Y nasopharyngeal swabs outbreak P681H performed phylodynamic Phylogenetic phylogenetic analyses Phylogenetic analysis phylogeographic analysis prevalent lineage respiratory resulting retrospective S protein S982A SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV-2 genomic sequence SARS-CoV-2 genomic sequences SARS-COV-2 infection SARS-CoV-2 isolate SARS-CoV-2 isolates severe acute respiratory syndrome Coronavirus Slovenia Spread study period Switzerland the S protein the SARS-CoV-2 Transmissibility transmissibility of SARS-CoV-2 United Kingdom USA variant virus VoC
[DOI] 10.3390/v13061098 PMC 바로가기 [Article Type] Article