Analysis of mechanisms of Shenhuang Granule in treating severe COVID-19 based on network pharmacology and molecular docking
Research article
[키워드] ABCB1
acute respiratory syndrome
Analysis
Calcium signaling
CAMP
Chinese
complex
component
coronavirus
coronavirus disease
COVID-19
CXCL8
Cytokine storm
database
DNMT1
docking
effective
enrichment analysis
expected
experiments
Functional enrichment analysis
Gene Expression Omnibus
GEO
Granule
HDAC3
Helicase
HSP90AA1
IFNg
indicated
inhibit
Interaction
Invasion
MDM2
mechanism
mechanisms
mild cases
MMP9
molecular docking
Molecular dynamics simulation
Multiple
network pharmacology
neuroactive
objective
pathway
performed
platform
predicted
protein targets
Protein–protein interaction
provide
PTGS2
randomized clinical trial
regulated
Result
Safe
SARS-CoV-2
severe COVID-19
Shenhuang granule
shown
Signaling
signaling pathway
stability
SwissTargetPrediction
target
therapeutic target
therapeutic targets
Treatment
TYMS
virus
were used
worse prognosis
[DOI] 10.1016/j.joim.2022.07.005 [Article Type] Research article
[DOI] 10.1016/j.joim.2022.07.005 [Article Type] Research article