Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvantsArticle Published on 2022-11-302022-11-15 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 진단, [키워드] abrogated ACE2 addition adjuvant adjuvants Adsorption alum aluminum Analysis Antigen approach binding booster Combination Complete conformational Coverage COVID-19 COVID-19 vaccine CpG decrease demonstrated destabilized domain dose ELISA exacerbated facilitate Formulation highlight host cell receptor immune responses immunogenicity IMPROVE in vitro in vivo Interaction interactions mice neutralize neutralizing antibody profile Protein RBD RBD antigen SARS-CoV-2 SARS-CoV-2 pseudovirus spike stability stability profile subunit vaccines temperature the receptor-binding domain Vaccine while [DOI] 10.1080/21645515.2022.2079346 PMC 바로가기
Porcine deltacoronavirus E protein induces interleukin-8 production via NF-κB and AP-1 activationArticle Published on 2022-11-012022-11-15 Journal: Veterinary microbiology [Category] SARS, 유전자 메커니즘, 치료제, [키워드] abrogated activated activating Activation acute respiratory syndrome Alpha antiviral immunity AP-1 binding C-terminal domain caused chemokine coronavirus coronavirus disease COVID-19 Cytokine release syndrome deleting demonstrated dependent on domain E E protein expression facilitate help IL-6 IL-8 induce Infection Inflammation inhibitor interleukin-6 IκBα life-threatening Local molecular mechanism motif NF-κB NF-κB pathway nuclear nuclear translocation p65 Pathogenesis PDCoV. Phosphorylation Proinflammatory cytokine promoter protein phosphorylation resulting SARS-CoV-2 Severe case upregulated [DOI] 10.1016/j.vetmic.2022.109553 PMC 바로가기
A comparative study of spike protein of SARS-CoV-2 and its variant Omicron (B.1.1.529) on some immune characteristicsArticle Published on 2022-10-122022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] abrogated activate activated affected antibody Antigen antigenic Antiviral B.1.1.529 binding ability Breakthrough infection comparable complement domain Effects epitope immune characteristics indicated induce inflammatory reaction macrophages molecular Mutation NF-κB nuclear omicron pathogen-associated molecular pathogenicity pro-inflammatory pro-inflammatory cytokine raise receptor S-protein SARS-CoV-2 Spike protein TAK-242 the vaccine Transmissibility trimer variant wild type [DOI] 10.1038/s41598-022-21690-7 PMC 바로가기
Toxicity and virucidal activity of a neon-driven micro plasma jet on eukaryotic cells and a coronavirusArticle Published on 2022-10-012022-11-15 Journal: Free radical biology & medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] abrogated airway antioxidant antiviral activity chronic wound clinics Cold Cold physical plasma complex Contact coronavirus cytotoxic effect cytotoxicity Direct Effect Effects eukaryotic cell fibroblast Gas plasma technology Hepatitis human cell line human cells human coronaviruses identify inactivation increasingly infections mechanism metabolic activity MHV murine murine hepatitis virus number of infected oxygen pandemic Patient physical plasma plethora reactive oxygen reactive oxygen species reduced responsible ROS ROS production Safe substrate the SARS-CoV-2 therapeutic purposes tissue Toxicity treat Treatment unique viability virucidal virus inactivation [DOI] 10.1016/j.freeradbiomed.2022.08.026 PMC 바로가기
A critical overview of current progress for COVID-19: development of vaccines, antiviral drugs, and therapeutic antibodiesArticle Published on 2022-09-122022-11-15 Journal: Journal of Biomedical Science [Category] SARS, 변종, 신약개발, 치료제, [키워드] abrogated acute respiratory syndrome addition Analysis antibodies antibody Antiviral antiviral drugs authorization BNT162b2 clinical benefits Clinical data clinical trial coronavirus COVID-19 Critical diagnostic distribution drug drugs Effect Effectiveness Efficacy effort Emergency global public health help Infection mRNA vaccines mRNA-1273 mutant strain Mutation Neutralizing antibodies neutralizing antibody neutralizing effect novel coronavirus disease omicron overcome pandemic presenting problems Regulatory SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 variant Scientific community shown small molecule Small molecule antiviral drugs small molecule drugs Support the spike protein therapeutic Therapeutics Treatment utility Vaccine Vaccine development Vaccines variant variants widespread [DOI] 10.1186/s12929-022-00852-9 PMC 바로가기
SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl – accumulation in respiratory epitheliumSARS-CoV-2 뉴클레오캡시드 단백질은 단백질-단백질 상호작용 매개 세포내 Cl-호흡 상피에서의 축적을 통해 과염증을 유발합니다Article Published on 2022-07-272022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 신약개발, 치료법, [키워드] abrogated Airway inflammation CAMP cell lines cells CFTR Concentration COVID-19 cystic fibrosis Cytokine storms Defense demonstrated depleting downregulated elicit epithelial epithelial cell epithelial cells expression fibrosis glucocorticoid Host host defense human airway epithelial hyperinflammation immune response immune responses Inflammatory response Inflammatory responses inhibition inhibitor Intracellular knockout microRNA modulating murine model murine models N protein pathogen phosphodiesterase Phosphorylation promoted Protein pulmonary inflammation raised reducing regulated respiratory epithelium resulting robust Rolipram SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid second messenger selective serum SGK1 signaling pathway Smad3 structural protein suggested sustained targeting therapeutic strategy transmembrane Trigger upregulation [DOI] 10.1038/s41392-022-01048-1 PMC 바로가기 [Article Type] Article
Immune boosting by B.1.1.529 ( Omicron) depends on previous SARS-CoV-2 exposureB.1.1.529(오미크론)에 의한 면역 강화는 이전 SARS-CoV-2 노출에 따라 다릅니다.Article Published on 2022-07-152022-09-11 Journal: Science (New York, N.y.) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (alpha abrogated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 B cell B cell response B.1.1.529 B.1.1.7 binding antibody BNT162b2 cellular immunity coronavirus cross-reactive HCW HCWs Health care Health care worker Immunity individual individuals Infection investigated less Lineage magnitude NAb neutralizing antibody neutralizing immunity omicron reduced respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe disease show protection against spike mutation Spike protein T and B cell responses T cell T cell response T cell responses Transmissibility vaccinated individuals variant variants of concern was reduced Wuhan [DOI] 10.1126/science.abq1841 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron variant escapes neutralizing antibodies and T cell responses more efficiently than other variants in mild COVID-19 convalescentsSARS-CoV-2 Omicron 변이체는 경증 COVID-19 회복기에서 다른 변이체보다 중화 항체 및 T 세포 반응을 더 효율적으로 탈출Article Published on 2022-06-212022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Beta abrogated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody Response Antigen antigen drift B.1.1.529 B.1.351 Beta Cell circulating Cohort conserved convalescent coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine cytokine response domain Epitopes evaluate FIVE Frequency humoral Immunity impair individuals Infection memory B memory B cell memory B cells memory T memory T cell Mild mutated neutralizing antibody omicron other variant Post-infection Re-infection Receptor-binding domain reduced Region respiratory risk SARS-CoV-2 Serum Neutralization severe acute respiratory syndrome Coronavirus significantly spike epitope spike epitopes spike-specific T cell T cell T cell immunity T cell response these cell These cells vaccination vaccination rate Variability variant variant of concern variants of concern virus Virus neutralization VoC VOCs [DOI] 10.1016/j.xcrm.2022.100651 PMC 바로가기 [Article Type] Article
Structural Dynamics of the SARS-CoV-2 Spike Protein: A 2-Year Retrospective Analysis of SARS-CoV-2 Variants (from Alpha to Omicron) Reveals an Early Divergence between Conserved and Variable EpitopesSARS-CoV-2 스파이크 단백질의 구조 역학: SARS-CoV-2 변이체(알파에서 오미크론까지)의 2년 후향적 분석을 통해 보존된 에피토프와 가변 에피토프 간의 초기 차이가 드러났습니다.Article Published on 2022-06-152022-09-11 Journal: Molecules [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] abrogated ACE2 binding ADE analyzed antibodies antibody Antibody-dependent enhancement antiviral strategy approaches bind binding circulating conformational change conserved COVID-19 infection D614G D614G mutation Delta determined by Divergence domain Dynamics epitope Epitopes Evolution facilitate facilitating antibodies flat help host cells linear mimicking molecular Molecular epidemiology Mutation N-terminal domain Neutralizing Neutralizing antibodies neutralizing antibody NTD omicron pandemic Retrospective analysis risk SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 strains SARS-CoV-2 variants selected spike Spike protein the SARS-CoV-2 the spike protein Vaccine Variability variable was determined [DOI] 10.3390/molecules27123851 PMC 바로가기 [Article Type] Article
SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1SARS-CoV-2 비구조 단백질 6은 ATP6AP1을 표적으로 하여 NLRP3 의존성 발열을 유발합니다Article Published on 2022-06-012022-09-11 Journal: Cell Death and Differentiation [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] abrogated activated Activation acute respiratory syndrome coronavirus Analysis Asymptomatic COVID-19 ATP6AP1 ATPase autophagic flux binding caspase-1 coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated epithelial cells exhibited impair induce Infection Inflammasome inflammasome activation inflammasomes inflammatory cell Inflammatory cell death inhibit inhibited interleukin L37F live SARS-CoV-2 lung epithelial cell Lung epithelial cells lung tissues lysosome acidification maturation metformin Mutation NLRP3 non-structural protein NSP6 overexpression Patient pharmacological Polydatin proton pump pyroptosis receptor signaling reduced respiratory SARS-CoV-2 serological markers severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 suggested Support Transcriptome transcriptome analysis Trigger triggered upstream vacuolar variant viral pathogenicity weakened [DOI] 10.1038/s41418-021-00916-7 PMC 바로가기 [Article Type] Article