Vitamin D and interferon-γ co-operate to increase the ACE-2 receptor expression in primary cultures of human thyroid cellsArticle Published on 2022-11-012022-11-15 Journal: Journal of Endocrinological Investigation [Category] COVID19(2023년), SARS, 진단, [키워드] ACE-2 ACE-2 receptor angiotensin Cell Cell culture cell membrane cells chain Combination combination treatment Course COVID-19 defend demonstrated experiment expressed expression Host IFN-γ immune defense immunocytochemistry in vitro data interferon-γ material membrane mRNA mRNA level observation primary culture Protein protein level reaction receptor RT-PCR SARS-CoV-2 shown supported Therapeutic benefit Thyrocytes Thyroid tissue treated Treatment up-regulate up-regulated up-regulating Vitamin D were measured would increase [DOI] 10.1007/s40618-022-01857-9 PMC 바로가기
Fatal Form of COVID-19 in a Young Male Bodybuilder Anabolic Steroid Using: The First Autopsied CaseArticle Published on 2022-09-292022-11-15 Journal: Medicina [Category] SARS, 진단, [키워드] ACE-2 receptor anabolic anabolic androgenic steroids androgenic steroid atherosclerotic plaques Autopsy COVID-19 death Diffuse alveolar damage Endothelitis form Genetic Genetic predisposition histopathological HLA allele immune system Infection kidneys liver lung male microthrombi Myocardial infarction Myocardium organs pancreas Patient positive Pulmonary edema risk risk factor SARS-CoV-2 SARS-CoV-2 RT-PCR test spleen steroid Testosterone Thromboembolism tissue [DOI] 10.3390/medicina58101373 PMC 바로가기
Gut-brain communication in COVID-19: molecular mechanisms, mediators, biomarkers, and therapeuticsArticle Published on 2022-09-012023-07-10 Journal: Expert review of clinical immunology [Category] COVID19(2023년), [키워드] ACE-2 receptor COVID-19 enteric nervous system gastrointestinal tract Gut-brain axis [DOI] 10.1080/1744666X.2022.2105697
The sex and gender dimensions of COVID-19: A narrative review of the potential underlying factorsReview article Published on 2022-09-012022-10-05 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE-2 ACE-2 receptor addition airway alcohol Biological difference cardiovascular diseases cells complex interplay coronavirus disease COVID-19 diabetes dimension discrepancy disorders downregulating Estrogen Evidence exhibited expression Factor Factors female females Gender Gender disparities health regulations Hormones immune response increase Infection involved kidney lung male Male sex males men men and women Mortality Multiple outcome outcomes progesterone protective role reduced risk risk factor Risk factors robust severe disease severity of COVID-19 Sex smoking Sociocultural effects statistically the SARS-CoV-2 viral infections virus with COVID-19 women [DOI] 10.1016/j.meegid.2022.105338 [Article Type] Review article
A potent virucidal activity of functionalized TiO2 nanoparticles adsorbed with flavonoids against SARS-CoV-2Article Published on 2022-09-012022-11-15 Journal: Applied Microbiology and Biotechnology [Category] SARS, 치료제, [키워드] ACE-2 ACE-2 receptor Adsorption angiotensin-converting enzyme-2 Anti-SARS-CoV-2 Activity antiviral activity Antiviral effect antivirals binding block caused Cell Cell culture cell entry coronavirus SARS-CoV-2 COVID-19 Critical death demonstrated develop displaying Effect event Flavanone-7-O-glucoside flavonoid HCoV 229E Hesperetin-7-rutinoside host cell impair impairing imperative in vitro induce interact Interaction interfere management mechanism mental health molecular docking analysis Nanoparticulate compound pandemic receptor Region SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike glycoprotein. spike glycoprotein Spread supportive care targeted therapy the SARS-CoV-2 viral infection virucidal [DOI] 10.1007/s00253-022-12112-9 PMC 바로가기
COVID-19 in animals: A need for One Health approachReview article Published on 2022-08-012022-10-05 Journal: Indian journal of medical microbiology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE-2 receptor affected approach article binding bioinformatic analysis cause caused Cell collected content COVID 19 COVID-19 COVID-19 case disease global pandemic Host Human in silico infected with SARS-CoV-2 Infection mechanism objective one health pathogen reported Respiratory disease risk of infection SARS- CoV-2 SARS-CoV-2 SARS-CoV-2 spike protein susceptible the disease Transmission while wild animals zoonosis zoonotic [DOI] 10.1016/j.ijmmb.2022.07.005 [Article Type] Review article
A novel high-throughput single B-cell cloning platform for isolation and characterization of high-affinity and potent SARS-CoV-2 neutralizing antibodies고친화도 및 강력한 SARS-CoV-2 중화 항체의 분리 및 특성화를 위한 새로운 고처리량 단일 B 세포 클로닝 플랫폼Article Published on 2022-07-012022-09-12 Journal: Antiviral Research [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE-2 receptor antibody B-cell binding Blood coronavirus COVID-19 Critical diagnosing Diseases domain effective ELISA high affinity highlight human cell Isolation mAb mAbs mAbs. Neutralizing Neutralizing activity neutralizing antibody Patient platform RBD RBD domain reporter S1 subunit SARS-CoV-2 SARS-CoV-2 neutralizing antibody single B cell Single B-cell cloning SPR Strategy the RBD the spike protein was used Wuhan-Hu-1 [DOI] 10.1016/j.antiviral.2022.105349 PMC 바로가기 [Article Type] Article
A Novel Human Neutralizing mAb Recognizes Delta, Gamma and Omicron Variants of SARS-CoV-2 and Can Be Used in Combination with Sotrovimab새로운 인간 중화 mAb는 SARS-CoV-2의 델타, 감마 및 오미크론 변이체를 인식하고 소트로비맙과 함께 사용할 수 있습니다Article Published on 2022-05-162022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE-2 ACE-2 receptor angiotensin angiotensin converting enzyme anti-spike MAbs antibody Can Casirivimab caused Cell culture cell cultures cell entry Clinical use combinatorial treatment combinatorial treatments coronavirus Delta diagnostic drug ENhance epidemics/pandemics epitope Epitopes Gamma glycoprotein Human Imdevimab immune system Infection inhibitory effect Interaction interfere investigated mAb mAbs monoclonal monoclonal antibodies Neutralizing Neutralizing activity neutralizing mAbs. novel omicron Omicron variant pandemic Pandemics Patient RBD Receptor binding domain recognize recognizing SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 virus Scientific community Sotrovimab spike spike glycoprotein Spike-RBD/ACE-2 subsequent the antibody the Spike therapeutic therapy variants virus virus infection [DOI] 10.3390/ijms23105556 PMC 바로가기 [Article Type] Article
The puzzling mutational landscape of the SARS-2-variant OmicronSARS-2 변종 오미크론의 수수께끼 같은 돌연변이 환경Article Published on 2022-05-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE-2 receptor affected antibody antibody susceptibility association cleavage site Complete coronavirus decrease deletions delta variant dissemination electrostatic Epitopes Evolution explain geometric human population immunological Infection initial initial assessment insertion less molecular mechanism molecular mechanisms mutations N-terminal domain neutralizing epitope neutralizing epitopes NTD omicron Omicron variant parameter Pathogenesis pathogenic phenotype predicted RBD Receptor-binding domain SARS Coronavirus SARS-CoV-2 variant Spike protein surface potential the receptor-binding domain Transmission Vaccine variant Virological virulence virus virus classification [DOI] 10.1002/jmv.27577 PMC 바로가기 [Article Type] Article
Application of the SARS-CoV-2-S1 ACE-2 receptor interaction as the basis of the fully automated assay to detect neutralizing SARS-CoV-2-S1 antibodies in blood samples혈액 샘플에서 중화 SARS-CoV-2-S1 항체를 검출하기 위한 완전 자동화 분석의 기초로서 SARS-CoV-2-S1 ACE-2 수용체 상호작용의 적용Article Published on 2022-05-012022-09-11 Journal: Journal of Immunological Methods [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] ACE-2 receptor ACE-2 receptor binding inhibition assay anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibody Antibody titer Antibody titers application automated binding blood sample Blood samples BNT162b2 Concentration Control convalescent patient Convalescent patients detect determine Diagnostic method EliA high correlation Interaction large cohort mRNA mRNA-1273 neutralization test Neutralizing Neutralizing antibodies neutralizing antibody neutralizing antibody titers Phadia plaque reduction neutralization PRNT provide quantified Quantitative SARS-CoV-2 SARS-CoV-2 S1 protein Sensitivity and specificity [DOI] 10.1016/j.jim.2022.113258 PMC 바로가기 [Article Type] Article