Are angiotensin converting enzyme (ACE1/ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A single-center cohort study안지오텐신 전환 효소(ACE1/ACE2) 유전자 변이가 COVID-19 폐렴의 임상 중증도와 관련이 있습니까? 단일 센터 코호트 연구Article Published on 2022-02-012022-09-11 Journal: Anatolian journal of cardiology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] abnormality ACE ACE gene ACE1 ACE1 gene ACE1/ACE2 ACE2 ACE2 gene Admission age allele Analysis angiotensin angiotensin converting enzyme automated Bioinformatics analysis Clinical characteristics Clinical severity Cohort cohort study coronavirus disease Coronavirus disease 2019 COVID-19 determine disease severity DNA domain DSP enzyme exon 1 frequencies Frequency functional Genetic Genomic DNA Genotype group I/D polymorphism ICU independent predictor independent predictors intensive care intensive care unit investigated knowledge no effect non-ICU Older age other variant pandemic Patient patients hospitalized Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes Pneumonia polymorphism Polymorphisms purified radiologic recent Sanger sequencing Science Sequencing analysis severe disease single-center statistical analysis Statistical Package variant was performed was used [DOI] 10.5152/AnatolJCardiol.2021.502 PMC 바로가기 [Article Type] Article
Assessment of ACE1 variants and ACE1/ACE2 expression in COVID-19 patientsCOVID-19 환자에서 ACE1 변이체 및 ACE1/ACE2 발현 평가Article Published on 2022-02-012022-09-11 Journal: Vascular pharmacology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE ACE1 ACE1 gene ACE1/ACE2 ACE2 ACE2 expression Affect allele angiotensinogen assessment association carrier carriers circulation Complication Control controls COVID-19 COVID-19 patient distribution ether examined expression expression level expression levels Expression. Frequency Genotype genotyped genotypes groups healthy controls I/D polymorphism ICU patient ICU Patients mRNA level non-ICU non-ICU patient non-ICU patients not different not significantly different p value Patient patients polymorphism Renin risk of COVID-19 significantly higher study groups total population transcripts two group two groups variant while [DOI] 10.1016/j.vph.2021.106934 PMC 바로가기 [Article Type] Article
The Role of Angiotensin Converting Enzyme 1 Insertion/Deletion Genetic Polymorphism in the Risk and Severity of COVID-19 InfectionMedicine Published on 2021-12-232022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE1 ACE1 ACE1 gene addition agarose gel age allele Analysis angiotensin association Blood carrier center clinical collected common allele Comorbidity Control COVID COVID-19 COVID-19 disease COVID-19 infection COVID-19 virus described determine disease disease severity DNA driving explain Factor Frequency Gender genetic differences Genetic polymorphism genetics Genotype genotyping greater Hospitalization I/D I/D polymorphism incidence increase in increased risk individual Infection Isolation management medical records outcome PCR PCR testing performed peripheral polymorphism positive predict Prognosis questionnaire recruited risk risk factor role severe symptom severity severity of COVID-19 Sex significantly higher significantly increased study population subjects susceptibility Symptom the disease university withdrawn [DOI] 10.3389/fmed.2021.798571 PMC 바로가기 [Article Type] Medicine
Angiotensin–Converting Enzyme (ACE) 1 Gene Polymorphism and Phenotypic Expression of COVID-19 Symptoms안지오텐신-전환 효소(ACE) 1 유전자 다형성 및 COVID-19 증상의 표현형 발현Review Published on 2021-10-012022-09-10 Journal: Genes [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] ACE1 I/D polymorphism ACE ACE1 ACE1 gene ACE2 Affect aldosterone Alu angiotensin appear article Asia association biochemical candidate Candidates Clinical outcome Comorbidities component concert conducted country COVID-19 COVID-19 symptoms diagnosis of SARS-CoV-2 East evaluate Evidence explain expression Frequency Genes Genotype group homolog Hypothesis I/D polymorphism Infection infections influence insertion Interaction involved mechanisms Medline database Mortality MOST numbers of patient opposite organ Pathogenesis pathogenesis of COVID-19 pathophysiology phenotypic Phenotypic Expression polymorphism Polymorphisms pulmonary disease RAAS reported Research risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections searched selected severity subgroups subgroups of patients Support Treatment West [DOI] 10.3390/genes12101572 PMC 바로가기 [Article Type] Review