ACE2 proteins – Communicable Diseases Research

Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections

비교 게놈 분석은 코로나 바이러스 감염에 대한 다양한 수준의 포유류 적응을 보여줍니다.

Comparative Study

Published on 2021-11-182022-09-10
Journal: PLoS Computational Biology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘,

Drug repurposing against SARS-CoV-2 receptor binding domain using ensemble-based virtual screening and molecular dynamics simulations

Research article

Published on 2021-08-012022-10-05
Journal: Computers in biology and medicine [Category] SARS, 신약개발,

[키워드] ACE2 proteins ACE2-RBD acute respiratory syndrome approach binding binding domain binding site caused Clustering analysis conformation conformational Conformational ensemble conformations Coronavirus-2 COVID-19 death docking scores drug drug design Drug repurposing drugs exhibited FDA approved drug help human ACE2 identify inhibiting Interaction investigated MD simulation MD simulations molecular Molecular dynamics simulation plasticity predicted RBD Receptor binding domain Respiratory disease responsible SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 receptor significantly Spike protein stability the RBD the SARS-CoV-2 Virtual screening virus infection were used worldwide pandemic
[DOI] 10.1016/j.compbiomed.2021.104634 [Article Type] Research article

Evidence that Maackia amurensis seed lectin (MASL) exerts pleiotropic actions on oral squamous cells with potential to inhibit SARS-CoV-2 infection and COVID-19 disease progression

Maackia amurensis seed lectin(MASL)이 SARS-CoV-2 감염 및 COVID-19 질병 진행을 억제할 가능성이 있는 구강 편평 세포에 다면발현 작용을 한다는 증거

Article

Published on 2021-06-012022-09-11
Journal: Experimental cell research [Category] SARS, 치료제,

[키워드] ACE2 ACE2 expression ACE2 protein ACE2 proteins ACE2 receptor addition agent Antiviral antiviral agent ARDS bind binding can be used caused Cell confirmed COVID-19 case COVID-19 COVID-19 disease COVID-19 patients Culture death decrease epithelial cell epithelial cells Express expression glycosylated glycosylation host cells identify infect infect cell Infection Inflammation Inflammatory inflammatory mediator Inflammatory mediators inhibit inhibit SARS-CoV-2 international public health kidney lectin Maackia amurensis Modification oral oral mucosa Oral squamous cells pandemic pleiotropic progression Protein respiratory tract SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus sialic acid Spike protein squamous suppresse target the SARS-CoV-2 the SARS-CoV-2 virus viral-host interaction
[DOI] 10.1016/j.yexcr.2021.112594 PMC 바로가기 [Article Type] Article

Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2

편자박쥐 ACE2 orthologs에서 파생된 돌연변이는 SARS-CoV-2의 ACE2-Fc 중화를 향상시킵니다

Research Article

Published on 2021-04-092022-09-10
Journal: PLoS Pathogens [Category] MERS, SARS, 변종,

[키워드] ACE2 ACE2 binding ACE2 ortholog ACE2 orthologs ACE2 proteins ACE2 residue ACE2-Fc acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 bat bat ACE2 bats binding binding affinity both viruses Cell cellular receptor Combination Consensus coronavirus described domain ENhance expressing FIVE hACE2 heterogeneity horseshoe bat horseshoe bats Human human ACE2 Hypothesis identify impacted inactive infect Infection Infectious virus Interaction intermediate introduced investigated Mutation neutralization neutralize neutralized Neutralizing ortholog orthologs pangolin pangolins potency Protein pseudovirus pseudoviruses RaTG13 RBD RBDs receptor receptor ACE2 Receptor-binding domain Region regions residue respiratory S-protein SARS-CoV SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 pseudoviruses SARS-CoV-2 RBD SARS-like coronavirus SARS-like viruses selection pressure severe acute respiratory syndrome Coronavirus soluble ACE2 species susceptibility the binding affinity the RBD the SARS-CoV-2 These data Variability variant Viral viral spike virus wild-type
[DOI] 10.1371/journal.ppat.1009501 PMC 바로가기 [Article Type] Research Article

Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry

비교 분석을 통해 SARS-CoV-2 진입에 필요한 ACE2의 종별 유전적 결정인자가 밝혀졌습니다.

Research Article

Published on 2021-03-242022-08-13
Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘,

[키워드] ACE2 ACE2 ortholog ACE2 orthologs ACE2 protein ACE2 proteins ACE2 sequence animal model binding can not cell entry cellular receptor Comparative analysis coronavirus Critical facilitate functional Genetic genetic determinant genetic determinants genetic engineering host cell host range Human human ACE2 Interaction koala limit mammalian mouse New World New World monkey receptor receptor function replaced REPLACED BY required residue restored restrict reveal SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike protein sequences shown Spike protein Support the spike protein Thr tissue tropism Viral viral entry viral spike protein
[DOI] 10.1371/journal.ppat.1009392 PMC 바로가기 [Article Type] Research Article

Applications of Protein Secondary Structure Algorithms in SARS-CoV-2 Research

SARS-CoV-2 연구에서 단백질 2차 구조 알고리즘의 적용

Review

Published on 2021-03-052022-09-11
Journal: Journal of Proteome Research [Category] SARS, 유전자 메커니즘,

[키워드] ACE2 ACE2 protein ACE2 proteins ACE2 receptor ACE2 receptors Algorithm Algorithms Amino acid amino acid sequence Analysis application binding affinity can be used can not compare protein Complete computational tool computational tools Contact Course COVID-19 evaluate example experiments explained faster Genome global effort help highlight homology information nucleotide pandemic Pandemics Protein protein similarity protein structure question reflected required Research SARS-CoV-2 SARS-CoV-2 spike protein secondary secondary structure sequence sequence similarities similarity Spike protein Structure the binding affinity Vaccine design viruses while zoonotic origin zoonotic origins
[DOI] 10.1021/acs.jproteome.0c00734 PMC 바로가기 [Article Type] Review

Evaluating angiotensin-converting enzyme 2-mediated SARS-CoV-2 entry across species

종에 걸친 안지오텐신 전환 효소 2 매개 SARS-CoV-2 진입 평가

Article

Published on 2021-01-012022-09-11
Journal: The Journal of Biological Chemistry [Category] 변종, 유전자 메커니즘,

[키워드] (greater horseshoe bat) (house mouse (red junglefowl) ACE2 ACE2 protein ACE2 proteins ACE2 receptor ACE2 receptors acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Canis cells Chinese complex coronavirus Critical cross-species demonstrated entry receptor evaluated Evaluating facilitate facilitated Felis goat greater greater horseshoe bat highlighting horseshoe bat Host hosts house mouse Hypothesis Infection Interaction intermediate hosts isoform Lupus mechanism Mus Mutation natural reservoirs nonsusceptible pandemic pangolin pangolins red junglefowl reservoir residue respiratory rhesus Rhesus monkeys Rufous horseshoe bat rufous horseshoe bat) SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection severe acute respiratory syndrome Coronavirus species susceptibility Tiger snake tiger snake) Viral viral entry virus
[DOI] 10.1016/j.jbc.2021.100435 PMC 바로가기 [Article Type] Article

The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins

SARS-CoV-2 스파이크 단백질은 포유류 ACE2 단백질에 대해 광범위한 친화성을 가지고 있습니다.

Research Article

Published on 2020-12-212022-08-13
Journal: PLoS Biology [Category] Biology and Life Sciences, COVID-19, Fulltext, SARS, 조류인플루엔자,

[키워드] absence ACE2 ACE2 protein ACE2 proteins ACE2 receptor ACE2 receptors addition aligned Amino acid amino acid residue amino acid residues amino acids angiotensin bat bat ACE2 bats bioinformatics cattle Cell changed China circulating Combination coronavirus coronavirus disease Coronavirus disease 2019 coronaviruses SARS-CoV COVID-19 Divergence examined global mortality glycoprotein Host host tropism Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human populations humans indicate infect Infection intermediate host investigated Live virus livestock mammalian Mutagenesis pandemic potential risk Protein Proteins RaTG13 receptor binding site receptors reservoirs SARS Coronavirus SARS coronavirus 2 SARS-CoV SARS-CoV-2 SARS-CoV-2 receptor sequence sequence similarity spike spike glycoprotein Spike protein the Spike thought tropism of SARS-CoV-2 Viral viral entry virus virus spread viruses wildlife zoonotic zoonotic transmission
[DOI] 10.1371/journal.pbio.3001016 PMC 바로가기 [Article Type] Research Article

Identifying the Zoonotic Origin of SARS-CoV-2 by Modeling the Binding Affinity between the Spike Receptor-Binding Domain and Host ACE2

스파이크 수용체 결합 도메인과 호스트 ACE2 간의 결합 친화도를 모델링하여 SARS-CoV-2의 인수공통 기원 확인

Article

Published on 2020-12-042022-09-11
Journal: Journal of Proteome Research [Category] SARS, 변종, 조류인플루엔자, 치료기술,

[키워드] ACE2 ACE2 protein ACE2 proteins ACE2 variant affinity amphibians Analysis approach binding binding affinity binding energy birds calculated candidate Candidates complex structure coronavirus correlated Critical Cutoff data sets determined by disease control domain Effectiveness EvoEF2 energy unit examined feasible fish highest Host host cells human infectious disease identify identifying Infection Infectious disease intermediate host intermediate hosts investigated Laboratory mammals modeling origin primates RBD reptiles Research risk of infection rodents SARS-CoV-2 spike receptor-binding domain susceptibility the binding affinity the Spike virus wild animals zoonotic origin
[DOI] 10.1021/acs.jproteome.0c00717 PMC 바로가기 [Article Type] Article

Blocking of the High-Affinity Interaction-Synapse Between SARS-CoV-2 Spike and Human ACE2 Proteins Likely Requires Multiple High-Affinity Antibodies: An Immune Perspective

Immunology

Published on 2020-09-172022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, SARS,

[키워드] ACE2 ACE2 protein ACE2 proteins adhere animal model antibodies antibody binding-affinity block blocking caused classical Combination comparison COVID-19 Critical crystal structure develop effective eight epithelial epithelial cells epitope felines Host Human human ACE2 IgA dimer Infection Interaction interaction-synapse interactions interface interfere intestine Multiple Neutralizing antibodies neutralizing antibody pandemic Protein protein-protein interaction Proteins SARS-CoV SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 transmission significant difference single antibody spike therapeutic therapy treating COVID-19 Vaccine virus X-ray
[DOI] 10.3389/fimmu.2020.570018 PMC 바로가기 [Article Type] Immunology