Molecular dynamics simulations highlight the altered binding landscape at the spike-ACE2 interface between the Delta and Omicron variants compared to the SARS-CoV-2 original strainArticle Published on 2022-10-012023-07-10 Journal: Computers in biology and medicine [Category] COVID19(2023년), [키워드] ACE2 receptors delta variant Omicron variant SARS-CoV-2 Spike protein [DOI] 10.1016/j.compbiomed.2022.106035 PMC 바로가기
Withania somnifera (L.) Dunal (Ashwagandha) for the possible therapeutics and clinical management of SARS-CoV-2 infection: Plant-based drug discovery and targeted therapyArticle Published on 2022-08-152022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 치료제, [키워드] ACE2 ACE2 receptors acute respiratory syndrome Analysis Anti-viral antiviral activity article Ashwagandha build Clinical management Compound coronavirus Coronavirus disease 2019 COVID-19 Critical disease drug Drug discovery flu help Immune homeostasis implicated Infection Inflammation information inhibit knowledge management MPro multiple organs organs other compounds pandemic parameter Patient patients Population pro-inflammatory cytokine protease provided Regulation SARS-CoV-2 SARS-COV-2 infection secure Side effect Standardization targeted therapy the patient Treatment Vaccine virus was performed Withania somnifera [DOI] 10.3389/fcimb.2022.933824 PMC 바로가기
Case report: Paradoxical manifestation of covid 19 induced thyroiditis in the unvaccinated patientCase report Published on 2022-08-012022-10-05 Journal: Annals of Medicine and Surgery [Category] 진단, 치료기술, [키워드] ACE2 receptors activate article bind binding Clinical finding clinical history COVID-19 cytotoxic T lymphocyte difficulty breathing finding history HLA hypothermia Hypothyroid Hypothyroidism Infection Laboratory Macrophage male manifested outcome Patient perspiration Physical symptom platform SAT severity steroid Subacute Symptoms symptoms of COVID-19 Thyroid thyroid follicular cell thyroid function Thyroiditis thyrotoxicosis treated unvaccinated vaccination Viral antigen weakness [DOI] 10.1016/j.amsu.2022.104204 [Article Type] Case report
Biodistribution and Cellular Internalization of Inactivated SARS-CoV-2 in Wild-Type Mice야생형 마우스에서 비활성화된 SARS-CoV-2의 생체분포 및 세포 내재화Article Published on 2022-07-092022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 ACE2 receptors administration analyzed angiotensin attachment Brain can not caveolin cell entry receptor cell line cellular cellular uptake clathrin Consensus conserved expression heart help heparan sulfate heparan sulfate proteoglycans heparin human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 in vitro in vivo inactivated infected with SARS-CoV-2 Inflammation internalization intravenous Intravenous administration mammalian mice molecular interaction motif mouse Muridae murine organ Proteoglycan raised reported SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 receptors Spike protein sulfate syndecan syndecan-4 syndecans syndecans. tissue TNF-α transmembrane various tissues wild-type [DOI] 10.3390/ijms23147609 PMC 바로가기 [Article Type] Article
Receptor binding domain of SARS-CoV-2 from Wuhan strain to Omicron B.1.1.529 attributes increased affinity to variable structures of human ACE2우한 균주에서 Omicron B.1.1.529까지의 SARS-CoV-2 수용체 결합 도메인은 인간 ACE2의 가변 구조에 대한 증가된 친화성을 특성으로 합니다.Article Published on 2022-07-012022-09-11 Journal: Journal of infection and public health [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] ACE2 ACE2 receptor ACE2 receptors ACE2 variant ACE2 variants ACE2-RBD affinity analysed Analysis angiotensin Angiotensin-converting enzyme attribute B.1.1.529 binding binding domain binding efficiency binding energy Care caused changes in coding region complexes contributing to COVID-19 detect determine docking dynamic Dynamic simulation enzyme Genetic variant genetic variants global pandemic help highlight homology model Homology models Human human ACE2 human host Infectious disease Interaction isolates lead management molecular molecular dynamics nucleotide omicron pathogenic polymorphism Protein docking RBD RBD complex RBDs receptor Receptor binding domain Repository retrieved risk RMSD RMSF Safe SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 virus SARS‐CoV‐2 selected severity single nucleotide stability Structural variant structural variants Structure the RBD Total variant Variation was performed wildtype Wuhan Wuhan strain [DOI] 10.1016/j.jiph.2022.06.004 PMC 바로가기 [Article Type] Article
MicroRNAs in the development of potential therapeutic targets against COVID-19: A narrative reviewReview article Published on 2022-07-012022-10-05 Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 바이오마커, 변종, 치료제, [키워드] ACE2 ACE2 receptor ACE2 receptors Antiviral biogenesis cellular miRNAs change chemokines collected complex conducted consequence COVID-19 cytokine Cytokines database Degradation Deleterious effective evaluate expression Extensive function generate Google help host response immune system include Infection infection process information inhibiting Interaction involved latency microRNA miRNA miRNAs Modification modulate Pathogenesis platform potential therapeutic target Prognosis reduce reduced regimen Regulation Regulatory Result SARS-CoV-2 SARS-COV-2 infection Science Direct Scientific community secretion Side effects Specific the SARS-CoV-2 therapeutic therapeutic target therapeutic targets Therapeutics therapy threat viral infection Viral load viral replication Viral RNA virus website WHO [DOI] 10.1016/j.jiph.2022.06.012 [Article Type] Review article
Inflammasome activation in infected macrophages drives COVID-19 pathology감염된 대식세포의 인플라마좀 활성화는 COVID-19 병리를 유발합니다Article Published on 2022-06-012022-09-12 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] ACE2 receptors activate Activation antibody attenuate blockade blocking cascade CD16 characterized contributing to COVID-19 COVID-19 pathology Critical disease downstream host infection Human immune system human macrophage humanized hyperinflammatory state IFN IL-1 IL-18 immune in vivo Infection Infectious virus Inflammasome inflammasome activation inflammasomes Inflammatory cytokine inflammatory cytokine production inflammatory macrophages Inflammatory response interferon Lung inflammation Lung pathology Lungs Macrophage macrophages NLRP3 inflammasome overactive pathology pathway Prevent pyroptosis Remdesivir Replication required SARS-CoV-2 SARS-COV-2 infection Stage sustained undergo viral replication Viral RNA [DOI] 10.1038/s41586-022-04802-1 PMC 바로가기 [Article Type] Article
How Do Point Mutations Enhancing the Basic Character of the RBDs of SARS-CoV-2 Variants Affect Their Transmissibility and Infectivity Capacities?SARS-CoV-2 변종 RBD의 기본 특성을 향상시키는 점 돌연변이가 전염성과 감염력에 어떤 영향을 미칩니까?Review Published on 2022-04-102022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 receptor ACE2 receptors arginine arginine residue arginine residues basic binding affinity cell receptors character charged residues contribute coronavirus coulombic charges COVID-19 creating delta variant difference Effect electrostatic Enhancing glutamic acid host cells increase in Infectivity lysine Mu variant mutations Omicron variant Point Point mutation point mutations RBD RBD-ACE2 Recognition residue Salt Bridge SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein spike protein RBD Spike proteins Spread spreading capacity surface electrostatic potential the RBD the SARS-CoV-2 the spike protein Transmissibility variants [DOI] 10.3390/v14040783 PMC 바로가기 [Article Type] Review
Cooperative multivalent receptor binding promotes exposure of the SARS-CoV-2 fusion machinery core협력 다가 수용체 결합은 SARS-CoV-2 융합 기계 코어의 노출을 촉진합니다Article Published on 2022-02-222022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding ACE2 receptor ACE2 receptors acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding binding affinity Cell conformational Cooperative coronavirus dissociation domains event induce Interaction membrane fusion molecular molecular dynamics Molecular dynamics simulation Population promote Protein Proteins receptor Receptor binding recognize S1 and S2 S1 and S2 domains S1 domain S1/S2 cleavage SARS-CoV-2 severe acute respiratory syndrome Coronavirus spike spike glycoprotein Spike proteins spike trimer spike trimers the SARS-CoV-2 therapeutic tomography variant virus [DOI] 10.1038/s41467-022-28654-5 PMC 바로가기 [Article Type] Article
Global Impact of COVID-19 on Colorectal Cancer Screening: Current Insights and Future Directions대장암 검진에 대한 COVID-19의 글로벌 영향: 현재 통찰력 및 미래 방향Review Published on 2022-01-102022-09-10 Journal: Medicina [Category] SARS, 치료기술, [키워드] ACE2 receptors Cancer cause of death center Colonoscopy Colorectal Colorectal cancer colorectal cancer screening coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic current death digestive direction flexible flexible sigmoidoscopy Future healthcare Impact individual insight liver Medicaid medical procedures Medicare organs pandemic reported SARS-CoV-2 screened service spread to surgical the United State United States [DOI] 10.3390/medicina58010100 PMC 바로가기 [Article Type] Review