Renin-angiotensin system blocker and the COVID-19 aggravation in patients with hypertension, diabetes, renal failure, Cerebro-cardiovascular disease, or pulmonary disease: Report by the COVID-19 Registry JapanObservational Study Published on 2022-10-012022-10-05 Journal: Journal of cardiology [Category] 임상, [키워드] ACEi/ARB acute respiratory syndrome Admission Analysis angiotensin-converting enzyme inhibitor ARB Associated factors association blocker chronic obstructive COPD coronavirus coronavirus disease correlation COVID-19 diabetes Diabetes Mellitus disease Disease outcome. Diseases enrolled extracorporeal membrane oxygenation Factor Female patients healthcare healthcare facility hypertension In-hospital death increased risk information intensive care Japan lower risk male Male sex outcome pandemic Patient patients positive Primary outcome Primary outcomes pulmonary disease receptor registry registry data renal renal impairment report risk severe COVID-19 severe renal impairment severity Support Treatment ventilator with COVID-19 [DOI] 10.1016/j.jjcc.2022.04.001 PMC 바로가기 [Article Type] Observational Study
Safety of ACEi and ARB in COVID-19 management: A retrospective analysisObservational Study Published on 2022-07-012022-10-05 Journal: Clinical Cardiology [Category] COVID19(2023년), SARS, 임상, [키워드] ACEi ACEi/ARB acute respiratory syndrome Affect Analysis angiotensin receptor blocker Angiotensin-converting enzyme ARB ARBs association clinical guideline complex interplay confounding variable congestive heart failure contagious coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients enrolled Evidence Factor hospital Host hypertension in-hospital mortality increased mortality individual Inflammatory response Interaction material medication Mortality multicenter multiorgan failure pathway Patient patient data patients Primary outcome regression analysis retrospective Retrospective analysis Safety SARS-CoV2 SARS-CoV2 infection severe COVID-19 severity severity of COVID-19 Society SQL USA variable virus was done were used [DOI] 10.1002/clc.23836 PMC 바로가기 [Article Type] Observational Study
Impact of renin-angiotensin-aldosterone system inhibition on mortality in critically ill COVID-19 patients with pre-existing hypertension: a prospective cohort studyObservational Study Published on 2022-03-232022-10-05 Journal: BMC Public Health [Category] 임상, [키워드] 95% CI ACEi/ARB acute respiratory syndrome adjusted analysed Analysis angiotensin angiotensin receptor blocker Angiotensin receptor blockers angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors ARB average baseline characteristics clinical Cohort coronavirus country COVID-19 COVID-19 patient COVID-19 patients Cox proportional hazard Critical care Critically ill death discharge enzyme evaluate examined hazard hospital Hospital stay hypertension ICU ICU admission ICUs Impact In-hospital death in-hospital mortality inhibitor intensive care unit International Mortality Observational cohort study Patient patient group prospective cohort study RAAS receptor reduced risk remains uncertain severe acute respiratory syndrome coronavirus 2 survival Trial registration was performed [DOI] 10.1186/s12872-022-02565-1 PMC 바로가기 [Article Type] Observational Study
Impact of RAAS Inhibitors on Clinical Outcome and Mortality in Patients With STEMI During the COVID-19 Era: A Multicenter Observational StudyCardiovascular Medicine Published on 2021-12-242022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] 95% CI ACEi/ARB Admission age analyzed benefit Care clinical Clinical outcome consecutive patient COVID-19 COVID-19 diagnosis COVID-19 pandemic detrimental diagnosed with COVID-19 Diagnosis Ejection fraction evaluate high-risk population Hospitalized Impact in-hospital mortality incidence of COVID-19 independent predictors Infection less logistic regressions lombardy males Mortality Multivariate analysis naïve nasopharyngeal swab test outcome overcome pandemic Patient patients patients with COVID-19 performed RAAS RAAS inhibitors reported respiratory complication Respiratory complications risk of COVID-19 significantly higher STEMI patients suggested Swab test therapy treated was performed [DOI] 10.3389/fcvm.2021.792804 PMC 바로가기 [Article Type] Cardiovascular Medicine
Angiotensin-Converting Enzyme Inhibitors, Angiotensin II Receptor Blockers, and Outcomes in Patients Hospitalized for COVID-19Observational Study Published on 2021-12-212022-10-05 Journal: Journal of the American Heart Association [Category] 임상, [키워드] 95% CI ACE ACE inhibitors ACEi/ARB adjusted hazard ratio Affect Angiotensin II angiotensin receptor blocker Angiotensin receptor blockers angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors association biomarkers of inflammation blood pressure C-reactive protein cell entry receptor clinical COVID-19 COVID‐19 death deaths dialysis dose examined Hospitalization In-hospital In-hospital death inclusion criteria Inflammation lower risk Measures mechanical ventilation modulating Mortality multivariable analysis need for dialysis outcome outcomes Patient patients hospitalized receptor Registration required Result SARS-CoV2 serum creatinine symptomatic thought Treatment Trial Ventilation [DOI] 10.1161/JAHA.121.023535 PMC 바로가기 [Article Type] Observational Study
Renin-Angiotensin System Blockers and the Risk of COVID-19-Related Mortality in Patients with Kidney FailureObservational Study Published on 2021-07-012022-10-05 Journal: Clinical journal of the American Society of Nephro [Category] SARS, 임상, [키워드] 28-day mortality 95% CI 95% confidence interval ACEi/ARB adjusted adjusted hazard ratio Admission affected angiotensin-converting enzyme inhibitor ARB ARBs association blocker both group calculate Comorbidities coronavirus disease COVID-19 database deleterious effect demographics diagnosis of COVID-19 dialysis died European evaluated failure hazard ratio higher risk Hospital admission information initial intensive care kidney Kidney failure kidney transplant recipient Kidney transplantation Mortality mortality risk outcome Participants Patient patients receptor recipient recipients renin angiotensin system retrieved risk severe COVID-19 severity severity of COVID-19 statistically significant subgroup Support System the patient ventilator with COVID-19 [DOI] 10.2215/CJN.18961220 PMC 바로가기 [Article Type] Observational Study
Association of ACEi/ARB Use and Clinical Outcomes of COVID-19 Patients With HypertensionCardiovascular Medicine Published on 2021-05-312022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] 95% CI ACE2 ACEi/ARB Admission Analysis angiotensin receptor blocker Angiotensin receptor blockers angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors ARB association clinical Clinical outcome composite endpoint confounding factor coronavirus disease COVID-19 COVID-19 patient Cox proportional hazard death disease severity Effect Endpoint enrolled evaluated event hypertension ICU increased risk intensive care Jiangsu main analysis mechanical ventilation multiple sensitivity analyses Occurrence outcome Pathogenesis Patient Probability progression randomized clinical trials receiving reduced regimens Retrospective study risk SARS-CoV-2 shown Treatment upregulated was performed Weighting Zhejiang [DOI] 10.3389/fcvm.2021.577398 PMC 바로가기 [Article Type] Cardiovascular Medicine
Evaluation of the Prognosis of COVID-19 Patients According to the Presence of Underlying Diseases and Drug Treatment기저질환 유무 및 약물치료에 따른 코로나19 환자의 예후 평가Article Published on 2021-05-172022-08-31 Journal: International Journal of Environmental Research an [Category] SARS, 치료제, [키워드] 95% CI 95% confidence interval ACEi ACEi/ARB Affect analyzed angiotensin angiotensin converting enzyme Angiotensin II ARBs benefit blocker Cancer Chronic kidney disease chronic obstructive chronic obstructive pulmonary disease Comorbidities cooperation coronavirus coronavirus disease COVID-19 COVID-19 cases COVID-19 patients diabete diabetes Diabetic disease disorder drug duration of hospitalization enzyme hazard ratio heart failure higher risk hypertension increased mortality increased the risk inhibitor international cooperation Kidney disease medical treatment Mental Mental disorder Mental Disorders Mortality obstructive pulmonary disease Patient patients patients with COVID-19 PCR tests Presence pulmonary disease receptor Receptor Blockers renal renal disease risk factor RT-PCR test RT-PCR tests severity significantly underlying disease underlying diseases was used [DOI] 10.3390/ijerph18105342 PMC 바로가기 [Article Type] Article
Impact of in-hospital discontinuation with angiotensin receptor blockers or converting enzyme inhibitors on mortality of COVID-19 patients: a retrospective cohort studyCOVID-19 환자의 사망률에 대한 지오텐신 수용체 차단제 또는 전환 효소 억제제의 병원 내 중단의 영향: 후향적 코호트 연구Research Article Published on 2021-05-122022-09-10 Journal: BMC Medicine [Category] SARS, 치료제, [키워드] 95%CI ACEi ACEi/ARB ACEIs adjusted Admission Adult patient Analysis angiotensin angiotensin receptor blocker Angiotensin receptor blockers angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors ARB ARBs carried Cohort cohorts conditions contrary COVID-19 COVID-19 pandemic Cox regression model death diabete diabetes discharge drug enzyme First wave hazard ratio hazard ratios head Head-to-head comparison heart failure High-risk patients hospital hospitals HRs Hypothesis Impact IMPROVE In-hospital In-hospital death in-hospital mortality in-hospital mortality rate in-hospital mortality rates In-hospital treatment increased the risk inhibitor intention-to-treat male mediators Mortality mortality rate mortality risk no difference obesity Older Patient patients with obesity PCR-confirmed PCR-confirmed diagnosis propensity scores Receptor Blockers reduced reduced risk Renin-angiotensin system inhibitors Result retrospective cohort study selected severity significantly lower Spain Spread subject supplementary material survival survival analysis the disease treat Treatment [DOI] 10.1186/s12916-021-01992-9 PMC 바로가기 [Article Type] Research Article
Effects of SARS-CoV-2 on Cardiovascular System: The Dual Role of Angiotensin-Converting Enzyme 2 (ACE2) as the Virus Receptor and Homeostasis Regulator-ReviewReview Published on 2021-04-262022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE inhibitor ACE-2 ACE2 ACE2 expression ACEi/ARB acute respiratory distress acute respiratory syndrome ADAM17 age alveolar Angiotensin II appear ARBs ARDS blocker cardiovascular cardiovascular disease cardiovascular system Cell cleavage Comorbidities Comorbidity coronavirus disease-2019 Coronavirus-2 COVID-19 COVID-19 mortality COVID-19 vaccine CVD domain driven by ectodomain Effect entry receptor enzyme excessive immune response expressed gastrointestinal tract Gender genetics homeostatic host cell humans immune response immune systems Interaction Leydig cell Lung epithelial cells multi-organ failure pandemic Patient priming Protein provide RAS renal tubular epithelium renin-angiotensin system required resulting role SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike spike glycoprotein syndrome TMPRSS2 transmembrane Treatment turn type I Vaccines vascular endothelial cells [DOI] 10.3390/ijms22094526 PMC 바로가기 [Article Type] Review