Short-term exposure of the mayfly larvae (Cloeon dipterum, Ephemeroptera: Baetidae) to SARS-CoV-2-derived peptides and other emerging pollutants: A new threat for the aquatic environmentsArticle Published on 2022-11-252022-11-15 Journal: The Science of the total environment [Category] SARS, 바이오마커, [키워드] acetylcholinesterase addition ambient aquatic environment aquatic environments Biomarker Biomarkers Cloeon Combination concentrations coronavirus dismutase DPPH ecosystem Effect evaluate evidenced Freshwater ecosystems groups hospital Impact Insects Mortality New coronavirus nitrite Non-target organisms novel Novel coronavirus organism Organisms PCA peptide peptides principal component analysis raised reduced response risk SARS-CoV-2 scavenging significantly lower similarity Spread Stress Topic Treatment viral peptide [DOI] 10.1016/j.scitotenv.2022.157813 PMC 바로가기
Potential of Essential Oil-Based Anticholinesterase Insecticides against Anopheles Vectors: A ReviewArticle Published on 2022-10-182024-08-29 Journal: Molecules [Category] 말라리아, [키워드] acetylcholinesterase insecticides malaria terpenoids
Shedding light on the toxicity of SARS-CoV-2-derived peptide in non-target COVID-19 organisms: A study involving inbred and outbred mice비표적 COVID-19 유기체에서 SARS-CoV-2 유래 펩타이드의 독성에 대한 조명: 근친교배 및 근친교배 마우스를 대상으로 한 연구Article Published on 2022-05-012022-09-11 Journal: Neurotoxicology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] acetylcholinesterase activated administration alteration animals antidepressant antioxidant anxiolytic applied biochemical Biomarker Brain C57Bl/6 J mice catalase consequence COVID-19 demonstrated depressive dismutase dispersion Effect Environmental Toxicology evaluate evaluated Evidence evidence of exposure to Field test genetic profile greater homeostasis hydrogen hydrogen peroxide Impact Laboratory locomotor maintain male mammalian mechanism memory memory deficit mice natural environments open oxidative stress Pandemic COVID-19 PCA peptide Principal component principal component analysis Protein Proteins provide reactive reduction in Research response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 particle SARS-CoV-2 particles sensitivity shedding Spike protein Superoxide Superoxide Dismutase Swiss mice. the Spike the vaccine Therapeutic strategies therapeutic strategy Toxicity Viral [DOI] 10.1016/j.neuro.2022.03.012 PMC 바로가기 [Article Type] Article
Optimization of covalent docking for organophosphates interaction with Anopheles acetylcholinesterasearticle Published on 2022-01-312024-09-01 Journal: Journal of Molecular Graphics and Modelling [Category] 말라리아, [키워드] acetylcholinesterase Anopheles covalent docking Molecular modeling Organophosphates [Article Type] article
Disorders of the Cholinergic System in COVID-19 Era—A Review of the Latest ResearchReview Published on 2022-01-082022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] ACE Acetylcholine acetylcholinesterase agonist angiotensin-converting enzyme 2 antiviral drug antiviral drugs binding can be used cause caused change cholinergic cholinergic system complex conducted connection COVID-19 COVID-19 virus cytokine production Cytokine storm demonstrated develop disorder disrupt dysregulation Effect epitope example in vitro in vivo inhibit initiated Morphological negative influence nervous system Nicotine nicotinic receptors Non-invasive physiological Prevent receptor reduce Research review SARS-CoV-2 SARS-CoV-2 spike protein sequence Structure System the SARS-CoV-2 virus therapy these compound virus [DOI] 10.3390/ijms23020672 PMC 바로가기 [Article Type] Review
Prospective, observational, single-centre cohort study with an independent control group matched for age and sex aimed at investigating the significance of cholinergic activity in patients with schizophrenia: study protocol of the CLASH-studyArticle Published on 2021-12-202022-10-05 Journal: BMJ Open [Category] SARS, 임상, [키워드] acetylcholinesterase addition adult psychiatry age and sex alteration anticipated approach approval association Butyrylcholinesterase calculated carried changes clinical clinical conditions clinical symptom code cognitive cognitive disorders cohort study control group Critically ill patient delirium delirium & Department disorders duration of illness enrolment esterase Ethics Evidence extension form Germany Hospital admission Hypothesis independent metabolism negative Neuroinflammation Observational cohort study parameter pathophysiological Patient point-of-care Prospective psychotherapy psychotic disorders. Registered required Sample size SARS-CoV-2 pandemic scale Schizophrenia schizophrenia & schizophrenic Secondary objective statistical analysis Study protocol Symptom the ethics committee Ulm university [DOI] 10.1136/bmjopen-2021-050501 PMC 바로가기 [Article Type] Article
Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive ReviewReview Published on 2021-10-292022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] acetylcholinesterase activity assessment bioactivities Biological biological properties Buddleja Central nervous system Characteristics characterized chemotaxonomy Cirsium CNS compounds Comprehensive derivatives dietary supplement disorders drug candidates Effect exhibited flavonoid flavonoids Health indicated inhibitory activity linarin Osteoarthritis Osteoporosis pharmacological phytochemistry Potential proliferation review therapeutic [DOI] 10.3390/ph14111104 PMC 바로가기 [Article Type] Review
The Positive Modulation Effect of a 6-Week Consumption of an Anthocyanin-Rich Mulberry Milk on Working Memory, Cholinergic, and Monoaminergic Functions in Healthy Working-Age AdultsResearch Article Published on 2021-08-312022-10-29 Journal: Oxidative Medicine and Cellular Longevity [Category] COVID-19, [키워드] acetylcholinesterase addition age assigned baseline cholinergic cognitive Consumption COVID-19 pandemic demonstrated Effect ENhance Evidence function High dose impairment in both group mechanism memory men and women milk occur Open-label randomized study Randomly reduction Saliva Stress study period subject suppresse tested Two-arm Volunteer was determined were assessed working working stress [DOI] 10.1155/2021/5520059 PMC 바로가기 [Article Type] Research Article
Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus서아프리카 Anopheles의 pirimiphos-methyl에 대한 내성은 Ace1 유전자좌의 복제 및 유전자이입을 통해 확산되고 있습니다.Research Article Published on 2021-01-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] ACE1 acetylcholinesterase African Analysis Anophele Anopheles gambiae approach association Carbamate Combination complex Control copy number diagnostic dominant driven by duplication duplications effective Effectiveness enzyme Genetic genomes genomic Haplotype highlight increasingly insecticidal insecticide insecticides Intervention locus malaria malaria vector molecular Mutation Non-synonymous occur organophosphate overcome phenotypic pirimiphos-methyl Population populations Predictive Predictive value predictor Prevent provide public health reduce Replication resistance resistance mechanism resistance mechanisms selection pressure sequenced specimen Spread sub-Saharan Africa Surveillance transferred Transmission unique Variation vector vectors West whole genome [DOI] 10.1371/journal.pgen.1009253 PMC 바로가기 [Article Type] Research Article
Anopheles metabolic proteins in malaria transmission, prevention and control: a review말라리아 전파, 예방 및 통제에서의 Anopheles 대사 단백질: 리뷰Review Published on 2020-09-102024-08-11 Journal: Parasites & Vectors [Category] 말라리아, [키워드] acetylcholinesterase immune response insecticide Insecticide resistance Plasmodium vector control [DOI] 10.1186/s13071-020-04342-5 PMC 바로가기 [Article Type] Review