Actions of Novel Angiotensin Receptor Blocking Drugs, Bisartans, Relevant for COVID-19 Therapy: Biased Agonism at Angiotensin Receptors and the Beneficial Effects of Neprilysin in the Renin Angiotensin System새로운 안지오텐신 수용체 차단 약물, 비사르탄, COVID-19 치료와 관련된 작용: 안지오텐신 수용체의 편향 작용 및 레닌 안지오텐신 시스템에서 네프릴리신의 유익한 효과Article Published on 2022-07-292022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 바이오마커, [키워드] 3CLpro ACE2 Action activated activating active site Agonism ANG Ang II angiotensin angiotensin converting enzyme Angiotensin II angiotensin II receptor blockers (ARBS) angiotensin II receptors Angiotensin receptor blockers anionic ARB/NEP docking ARBs AT1 AT2 biased agonism binding biphenyl bisartans blocker blocking cells charge relay system (CRS) complementary COVID-19 COVID-19 virus DNA driven by edema Effect endopeptidase enzyme Evidence explained furin G protein Human genome humoral hypertension in silico inhibit inhibiting inverse agonist involved modulating molecular molecular dynamics Molecular dynamics (MD) mRNA neprilysin novel opposite peptide peptides Protein Pulmonary edema RAS receptor Receptor Blockers receptors Renin SARS-COV-2 infection sartans Screening Serine serine proteases switching System tetrazole this system Treatment Vasoactive viral entry Zinc [DOI] 10.3390/molecules27154854 PMC 바로가기 [Article Type] Article
Paxlovid: Mechanism of Action, Synthesis, and In Silico StudyPaxlovid: 작용 메커니즘, 종합 및 인 실리코 연구Review Published on 2022-07-072022-09-11 Journal: BioMed Research International [Category] COVID19(2023년), SARS, 치료제, [키워드] Action antiviral activity antiviral drug antiviral efficacy antivirus antiviruses Biochemistry candidate cleave clinical trial Combination coronavirus COVID COVID-19 COVID-19 pandemic described description drug flexible Glutamine human coronavirus Immune profile in vitro in vivo inhibiting inhibitor mechanism mechanism of action molnupiravir Nirmatrelvir Organic chemistry pandemic Paxlovid PF-07321332 Pfizer Pharmacology polyprotein protease Protease inhibitor Proteases replaced REPLACED BY reported Ritonavir SARS-CoV-2 protease synthesis Treatment treatment of COVID-19 Vaccine viral replication [DOI] 10.1155/2022/7341493 PMC 바로가기 [Article Type] Review
Novel TB smear microscopy automation system in detecting acid-fast bacilli for tuberculosis – A multi-center double blind studyRandomized Controlled Trial Published on 2022-07-012022-10-05 Journal: Tuberculosis (Edinburgh, Scotland) [Category] 임상, [키워드] Accuracy Action artificial artificial intelligence Automated microscope complement connection COVID-19 pandemic Culture diagnosed Diagnosis discrepancy double blind double-blind trial Efficiency enrolled evaluate gold standard Laboratory manual Medical resources Microscopy mitigate molecular Negative predictive value novel Prevalence pulmonary tuberculosis recent reduce Result sensitivity Sensitivity and specificity smear microscopy TB Smears. Total Tuberculosis [DOI] 10.1016/j.tube.2022.102212 PMC 바로가기 [Article Type] Randomized Controlled Trial
A phase 2 randomized, double-blinded, placebo-controlled, multicenter trial evaluating the efficacy and safety of raloxifene for patients with mild to moderate COVID-19Research article Published on 2022-05-122022-10-05 Journal: EClinicalMedicine [Category] 신약개발, 임상, [키워드] Action acute respiratory syndrome adaptive clinical testing consumer coronavirus disease-2019 Coronavirus-2 COVID COVID-19 COVID-19 disease current decrease doses double-blinded Effect Efficacy and safety Emergency Endpoint enrolled Estrogen European Commission evaluate Evidence finding FIVE funding hospitalized patients immunomodulator indications instrument Italian Italy lack mechanical ventilation Medicine Mild Ministry of Health mitigate moderate Moderate COVID-19 modulate multicenter Multicenter trial Nasopharyngeal swab Occurrence participant Patient pharmacological Phase 2 study Placebo placebo-controlled placebo-controlled trial Prevent Primary outcome progression proinflammatory cytokines proportion raloxifene Randomized receive Registered Replication reported Safety safety profile SARS-CoV-2 Selective estrogen receptor modulator (SERM) Serious Adverse Events Seven supplemental oxygen Supplemental oxygen therapy Support supported therapeutic option treat Treatment Trial undetectable viral shedding [DOI] 10.1016/j.eclinm.2022.101450 [Article Type] Research article
The global impact of COVID-19 on drug purchases: A cross-sectional time series analysisCOVID-19가 의약품 구매에 미치는 글로벌 영향: 횡단면 시계열 분석Article Published on 2022-05-012022-09-11 Journal: Journal of the American Pharmacists Association : [Category] 치료제, [키워드] Action adrenergic drug Analysis antiviral drugs average change changes in class conducted coronavirus disease Coronavirus disease 2019 correction country COVID-19 COVID-19 pandemic cross-sectional determine Disruption distribution drug events Evidence evidence of greater Health Organization increase in inhaler inhalers IQVIA medication Medicine Medicines moving average pandemic Pandemics ranged risk subsequent Supply chain tested United Nation United Nations were assessed World Health Organization [DOI] 10.1016/j.japh.2021.12.014 PMC 바로가기 [Article Type] Article
International Association for the Study of Lung Cancer Study of the Impact of Coronavirus Disease 2019 on International Lung Cancer Clinical TrialsResearch article Published on 2022-05-012022-10-05 Journal: International Journal of Molecular Sciences [Category] 임상, [키워드] Action aggregate approach clinical clinical trial clinical trials collected Collection Compliance coronavirus disease COVID-19 COVID-19 pandemic declined decrease effective eligible patient Enrollment evaluate the effect evaluated flexible Impact IMPROVE investigator Laboratory lung cancer medication Mitigation MOST not significantly different occurred pandemic protocol reductions in required Result significant decrease Site survey Symptom Travel Trial trials were used worsened [DOI] 10.1016/j.jtho.2022.01.017 [Article Type] Research article
CHARM: COVID-19 Health Action Response for Marines-Association of antigen-specific interferon-gamma and IL2 responses with asymptomatic and symptomatic infections after a positive qPCR SARS-CoV-2 testCHARM: qPCR SARS-CoV-2 테스트 양성 후 무증상 및 증상 감염에 대한 항원 특이적 인터페론-감마 및 IL2 반응의 해병을 위한 COVID-19 건강 조치 대응Article Published on 2022-04-072022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, 치료법, [키워드] Action All participants Asymptomatic Asymptomatic cases Cell mediated immunity class correlated COVID-19 COVID-19 symptoms COVID-19 vaccine COVID-19 vaccines dropped enrolled Enrollment epitope Epitopes Follow-up frequencies Frequency IFN-γ IFN-γ response IFN-γ responses IL2 immune response include Infection membrane N and M N and S proteins N protein nucleocapsid occurred participant Participants peaked peptide peptide pool peptides positive Post-infection predicted Protein Proteins qPCR qPCR test Responder response responses S proteins S, N and M proteins SARS-CoV-2 SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 test significantly Study participants subjects Support symptomatic symptomatic and asymptomatic symptomatic infection symptomatic participants T cell T cell response T cell responses tested the N protein These data were measured with COVID-19 [DOI] 10.1371/journal.pone.0266691 PMC 바로가기 [Article Type] Article
The INDEPTH (Impact of Nuclear Domains on Gene Expression and Plant Traits) Academy: a community resource for plant scienceINDEPTH(유전자 발현 및 식물 특성에 대한 핵 도메인의 영향) 아카데미: 식물 과학을 위한 커뮤니티 리소스Article Published on 2022-04-052022-09-11 Journal: Journal of experimental botany [Category] 유전자 메커니즘, [키워드] Academy Action Analysis automated Community community resource Control COST Action COVID-19 pandemic deep learning driven by engage Epigenetic epigenetics Gene Expression growth image repository Impact Laboratory nuclear nucleus Open Access plant plants produced protocols provide recent Repository researcher resource resources Standardization standardized protocols Support tutorials webinars. [DOI] 10.1093/jxb/erac005 PMC 바로가기 [Article Type] Article
COVID-19 Confinement Effects on Game Actions during Competition Restart in Professional Soccer PlayersObservational Study Published on 2022-04-022022-10-05 Journal: International Journal of Environmental Research an [Category] 임상, [키워드] Action Affect analysed average competition COVID-19 decrease Effect effect size effort Football game GPS HSR increase in intensity intensity level involved lockdown methodology participated performance physical physical demands playing position. professional restart Spain Spanish substitutions variable was used [DOI] 10.3390/ijerph19074252 PMC 바로가기 [Article Type] Observational Study
Effectiveness of the BNT162b2 (Pfizer-BioNTech) and the ChAdOx1 nCoV-19 (Oxford-AstraZeneca) vaccines for reducing susceptibility to infection with the Delta variant (B.1.617.2) of SARS-CoV-2BNT162b2(화이자-바이오엔텍) 및 ChAdOx1 nCoV-19(옥스포드-아스트라제네카) 백신의 SARS-CoV-2 델타 변이형(B.1.617.2) 감염에 대한 감수성 감소 효과Article Published on 2022-03-202022-09-11 Journal: BMC Infectious Diseases [Category] SARS, 변종, 치료기술, [키워드] Action Alpha Alpha variant assumed B.1.1.7 B.1.617.2 BNT162b2 ChAdOx1 ChAdOx1 nCoV-19 Combined Complete Course COVID-19 COVID-19 vaccination programme credible interval delta variant dose doses effective Effectiveness Epidemic explain finding health record Infection Infectious disease intelligence modelling Oxford Oxford-AstraZeneca PCR Pfizer-BioNTech Population predominant provide public health receiving reduce reducing resource SARS-CoV-2 SARS-COV-2 infection single dose Single-dose SIR susceptibility susceptibility to infection symptomatic and asymptomatic Transmission Vaccine variant [DOI] 10.1186/s12879-022-07239-z PMC 바로가기 [Article Type] Article