Natural products from medicinal plants in Asia and the Pacific for RNA viruses: Hercules’ fifth labourArticle Published on 2022-12-012022-11-15 Journal: Pharmaceutical Biology [Category] 치료제, [키워드] active against Analysis antiviral activity antiviral drug antiviral drugs Asia Asian ChemSpider Direct distribution Google Scholar Hercule hydroxytyrosol identify in vivo material molecular natural plant PubChem RNA RNA virus Science Treatment viral genome replication viral infections virus Web of Science with COVID-19 zoonotic [DOI] 10.1080/13880209.2022.2130944 PMC 바로가기
When the Dust Has Settled: Calculation of Binding Affinities from First Principles for SARS-CoV-2 Variants with Quantitative AccuracyArticle Published on 2022-10-112022-11-16 Journal: Journal of chemical theory and computation [Category] COVID19(2023년), SARS, 변종, [키워드] Accuracy ACE2 active against acute respiratory syndrome affinity angiotensin-converting enzyme 2 antibodies antibody applied Beta binding binding free energy biological processe calculation complex coronavirus coronavirus disease Delta delta variant Diversity dust effective estimate host cell Immune escape immune response information methodology molecular omicron Perspective Predictive principle receptor robust SARS-CoV-2 Support the binding affinity the receptor-binding domain Therapies Transmissibility variant variants widespread wild type [DOI] 10.1021/acs.jctc.2c00604 PMC 바로가기
Activity of ertapenem/zidebactam (WCK 6777) against problem EnterobacteralesArticle Published on 2022-09-302022-11-16 Journal: Journal of Antimicrobial Chemotherapy [Category] SARS, 비임상, [키워드] 1:1 active against activity administration breakpoint Dilution E. coli Escherichia coli evaluated experiments group healthcare increasingly indicated Infection inhibited isolate Klebsiella KPC Laboratory material MDR National nosocomial Outpatient over Parenteral pathogen Patient proportion regimen SARS-CoV-2 secondary submitted Support susceptibility Trial will drive [DOI] 10.1093/jac/dkac280 PMC 바로가기
Semisynthetic teicoplanin derivatives with dual antimicrobial activity against SARS-CoV-2 and multiresistant bacteriaArticle Published on 2022-09-262022-11-15 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] active against Affect Antibiotics antimicrobial Antiviral approved Bacteria Bacterial cells Co-infection Compound conjugate coronavirus derivative drug drugs effective Efficacy Endemic endosomal entry enzyme HCoV-229E human Calu-3 cell hydrophobic infected with SARS-CoV-2 inhibiting inhibition assay inhibitor membrane modifications Prevent Prognosis risk RNA virus SARS-CoV-2 SARS-CoV-2 replication Seven shown VeroE6 cells [DOI] 10.1038/s41598-022-20182-y PMC 바로가기
Current status of antihistamine drugs repurposing for infectious diseasesReview article Published on 2022-09-012022-10-05 Journal: Medicine in Drug Discovery [Category] 신약개발, [키워드] active against Anti-infective Antihistamines applicability article Blood brain barrier Candida carried Chemical library clinical trial clinical trials cross current determine dose drug Ebola virus Efficacy English eventual need FIVE Google Scholar Government groups growth Health hepatitis C IC50 identify in vitro activity in vitro data in vivo Infectious disease information inhibited intrinsically lack Leishmania objective off-label Pathogens pharmacological Plasmodium repurposing Research Result rodents Side effects Staphylococcus aureus Staphylococcus epidermidis Support suppressed Trial Trypanosoma virus [DOI] 10.1016/j.medidd.2022.100140 [Article Type] Review article
A Booster Dose of CoronaVac Increases Neutralizing Antibodies and T Cells that Recognize Delta and Omicron Variants of ConcernArticle Published on 2022-08-302022-11-15 Journal: mBio [Category] SARS, 변종, 진단, [키워드] active against addition Adults anti-SARS-CoV-2 anti-SARS-CoV-2 immune responses approved booster booster dose Brazil CD4 cellular Chilean China clinical trial concern CoronaVac COVID-19 Delta dose doses Emergency use healthy healthy volunteers homologous humoral immune response Immunity immunized IMPROVE inactivated Inactivated vaccine increase interferon neutralizing antibody not significantly different omicron phase phase III clinical trial. previous study reached reduced reported SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2-specific T cell second dose secretion shown significant increase significantly T cell T cell activation T cell response the vaccine these cell Turkey vaccination schedule Vaccine variants of concern VoC VOCs were assessed WHO World Health Organization [DOI] 10.1128/mbio.01423-22 PMC 바로가기
In Silico Evaluation of Sesquiterpenes and Benzoxazinoids Phytotoxins against Mpro, RNA Replicase and Spike Protein of SARS-CoV-2 by Molecular Dynamics. Inspired by NatureArticle Published on 2022-08-292022-11-15 Journal: Toxins [Category] SARS, 치료제, [키워드] active against added addition Analysis antiviral activities benzoxazinoid calculated candidate complex complexes Compound COVID-19 derivative derivatives described docking docking score Dynamics ENhance evaluated fluctuation generate Hydrogen bond in silico interactions kinetic M pro molecular molecular docking molecular dynamics MPro Nature Phytotoxin protease Protein protein-ligand replicase RMSD RNA SARS-CoV-2 selected Sesquiterpene shown spike spike glycoprotein Spike protein stability tested the spike protein virus were assessed [DOI] 10.3390/toxins14090599 PMC 바로가기
Quinolizidines as Novel SARS-CoV-2 Entry InhibitorsArticle Published on 2022-08-252022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 치료제, [키워드] active against acute respiratory syndrome aloperine aloperine derivatives. anti-SARS-CoV-2 Antiviral compound can be used caused Cell Compound confocal microscopy Coronavirus-2 COVID-19 D614G variant Delta derivative derivatives develop entry inhibitors entry of SARS-CoV-2 host cells Influenza virus inhibit inhibited membrane novel omicron outbreak pandemic Result SARS-CoV-2 SARS-CoV-2 inhibitor SARS-CoV-2 variant Spread tested viral entry virus viruses [DOI] 10.3390/ijms23179659 PMC 바로가기
In vitro activity of therapeutic antibodies against SARS-CoV-2 Omicron BA.1, BA.2 and BA.5SARS-CoV-2 Omicron BA.1, BA.2 및 BA.5에 대한 치료 항체의 시험관 내 활성Article Published on 2022-07-232022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] active against Alter antibody cilgavimab D614G delta variant European Fold change growth less Lineage lineage B.1 monoclonal antibodies monoclonal antibody Mutation neutralising not enhanced omicron reduction replacement SARS-CoV-2 significantly Sotrovimab Spectrum spike glycoprotein strain therapeutic therapeutic antibodies Tixagevimab union variant of SARS-CoV-2 variants [DOI] 10.1038/s41598-022-16964-z PMC 바로가기 [Article Type] Article
Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses신종 바이러스에 대해 활성을 나타내는 광범위한 항바이러스제로서 타고난 면역 신호의 인핸서 식별Article Published on 2022-07-212022-09-11 Journal: Cell chemical biology [Category] COVID19(2023년), SARS, 치료제, [키워드] active against acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral activity boost broad-spectrum antiviral broad-spectrum antivirals Compound coronavirus Defense dependent on Drug screening emerging viruses enhancer Factors Gilteritinib identifying Immunity immunomodulatory molecules immunostimulatory IMPROVE increasingly Infection Innate innate immune innate immune activation Innate immunity innate response interferon interferon regulatory factor interferon regulatory factors. IRF7 IRFs Kinase inhibitor kinase inhibitors library nuclear translocation outbreak Pandemics pathogenic virus pathogenic viruses Pathogens proof proof of concept Regulatory RNA viruses SARS-CoV-2 screened severe acute respiratory syndrome Coronavirus Signaling viral infection virus [DOI] 10.1016/j.chembiol.2022.05.009 PMC 바로가기 [Article Type] Article