The potential mechanism of the Ruhao Dashi formula in treating acute pneumonia via network pharmacology and molecular docking4200 Published on 2023-03-172024-09-05 Journal: Medicine [Category] update2024, [키워드] acute pneumonia Functional enrichment analysis molecular docking network pharmacology Ruhao Dashi formula [DOI] 10.1097/MD.0000000000033276 PMC 바로가기 [Article Type] 4200
The therapeutic promises of Lianhuaqingke in the mice model of coronavirus pneumonia (HCoV-229E and SARS-CoV-2)Research Published on 2021-10-182022-11-01 Journal: Chinese Medicine [Category] COVID-19, [키워드] 16HBE cell acute pneumonia airway alleviate Anti-HCoVs therapy Anti-viral Antiviral effect approved BALB/c mice caused Cell cells ciliary Coronavirus pneumonia COVID-19 dose-dependent Effect ELISA epithelial expression expression level flow cytometry H&E staining hACE2 HCoV-229E human coronaviruses (HCoVs) identify immune response immunofluorescence staining immunomodulation immunomodulatory in vitro in vivo indicated inhibit inhibited inhibiting Injury Lianhuaqingke (LHQK) lung lung tissue lung tissues mice morphological change MUC5AC Peripheral blood Pneumonia positive pro-inflammatory cytokine reduce reduced reducing Replication Result SARS-CoV-2 staining subset Th cell Th1 Th17 Th2 the SARS-CoV-2 virus therapeutic therapeutic effect Therapies TNFα Transgenic mouse treated Treatment Treg Vero E6 viral replication virus virus titer was measured was used weight loss were measured [DOI] 10.1186/s13020-021-00513-3 PMC 바로가기 [Article Type] Research
Clinical efficacy and security of glycyrrhizic acid preparation in the treatment of anti-SARS-CoV-2 drug-induced liver injury: a protocol of systematic review and meta-analysis항 -SARS-COV-2 약물-유도 간 손상의 치료에서 혈당산 제제의 임상 효능 및 보안 : 체계적인 검토 및 메타 분석의 프로토콜Article Published on 2021-07-092022-08-31 Journal: BMJ Open [Category] meta-analysis, SARS, [키워드] acute pneumonia analyses Analysis anti-SARS-CoV-2 antiviral effects assessment China Chinese clinical clinical variable Cochrane Handbook collected conducted confidence COVID-19 COVID-19 research cumulative defined development Drug-induced liver injury Efficacy English Ethical approval Ethics Evidence Final geographical region glycyrrhizic acid Grey literature guidelines Handbook Healthcare professional healthcare professionals heterogeneity Infectious disease Infectious diseases infectious diseases & infestations Infrastructure item journal language limitation liver Liver injury Meta-analysis meta-regression OVID Patient patients patients with COVID-19 peer-reviewed performed Pneumonia PROSPERO protocol protocols protocols & public health Quality Randomised controlled trials registration number Reporting required researcher Retrospective study review Risk of bias Scientific community screened security selected single-arm trial study population Subgroup analyses systematic review systematic reviews Treatment Web of Science [DOI] 10.1136/bmjopen-2021-051484 PMC 바로가기 [Article Type] Article
A Phase 3 Open-label, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Intravenously Administered Ravulizumab Compared with Best Supportive Care in Patients with COVID-19 Severe Pneumonia, Acute Lung Injury, or Acute Respiratory Distress Syndrome: A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-07-132022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 24 hour 48 hour Activation acute lung injury acute pneumonia acute respiratory distress syndrome Administered Adult age all-cause mortality Amendment antibodies antibody Antibody test anticipated antiviral therapy approval ARDS assessment assigned baseline Biomarker Blood cardiac disease Care change class Clinical improvement clinical study clinical trial complement Complement inhibitor component Computed tomography concealed Concentration conducted Confirmed Controlled coronary syndrome COVID-19 criteria current Day diagnosis of SARS-CoV-2 dialysis discharge dissemination dose Duration Efficacy element eligibility Endotracheal intubation EU Clinical Trial EudraCT evaluate the effect expected failure female patient Final fraction France Germany greater half-live hospital Hospitalization humanized Hypercoagulable state Immunoglobulin Infection Inflammatory inhibitor initiated intensive care Intubated intubation invasive Invasive mechanical ventilation investigator IVIG Japan Lung injury mechanical ventilation medication monoclonal multicenter Neisseria meningitidis Non-invasive number objective Open-label original outcome oxygen participant Patient patients randomized patients with COVID-19 Period peripheral capillary phase Placebo Pneumonia polymerase chain positive airway pressure presenting progression protocol randomised randomised controlled trial randomization randomization list Randomized randomized controlled study Randomly Ravulizumab receive recruitment registry Remdesivir renal respiratory respiratory distress Respiratory distress syndrome routine clinical care Safety screened Screening secondary Serious Adverse Events serum severe acute respiratory distress syndrome coronavirus 2 Severe acute respiratory syndrome severe COVID-19 severe pneumonia SOFA Spain SpO2 Sponsor stratified Study protocol supportive care survival The United States therapy time Treatment treatment-emergent adverse event Ultomiris United Kingdom ventricular Viral website with COVID-19 X-ray [DOI] 10.1186/s13063-020-04548-z PMC 바로가기 [Article Type] Letter
Electronic Cigarette (E-Cigarette) Vapor Exposure Alters the Streptococcus pneumoniae Transcriptome in a Nicotine-Dependent Manner without Affecting Pneumococcal Virulence전자담배(E-담배) 증기 노출이 니코틴 의존적인 방식으로 폐렴구균의 전사체를 변화시키지만 폐렴구균의 병원성에는 영향을 미치지 않는다.Article Published on 2020-01-212024-08-24 Journal: Applied and Environmental Microbiology [Category] 폐렴구균 감염증, [키워드] acute pneumonia Biofilms E-cigarette RNA-Seq Streptococcus pneumoniae Transcriptome vaping
COVID-19 – what should anaethesiologists and intensivists know about it?Review Published on 2020-01-012023-07-05 Journal: Anaesthesiology intensive therapy [Category] SARS, [키워드] acute pneumonia acuterespiratory distress syndrome (ARDS) COVID-19 Infection SARS-CoV-2 viruses [DOI] 10.5114/ait.2020.93756 [Article Type] Review