In silico and in vitro evaluation of imatinib as an inhibitor for SARS-CoV-2Article Published on 2023-04-012023-07-08 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), [키워드] ACE2 acute respiratory disease Bcr-Abl tyrosine kinase inhibitor Betacoronavirus COVID-19 Imatinib molecular docking SARS-CoV-2 surface structural spike glycoprotein. Wuhan [DOI] 10.1080/07391102.2022.2045221 PMC 바로가기
COVID-19 Australia: Epidemiology Report 68 Reporting period ending 20 November 2022Article Published on 2022-12-192023-07-11 Journal: Communicable diseases intelligence (2018) [Category] COVID19(2023년), [키워드] 2019-nCoV acute respiratory disease Australia Coronavirus disease 2019 COVID-19 Epidemiology Novel coronavirus SARS-CoV-2. [DOI] 10.33321/cdi.2022.46.86 PMC 바로가기
COVID-19 Australia: Epidemiology Report 66 Reporting period ending 25 September 2022Article Published on 2022-10-252023-07-10 Journal: Communicable diseases intelligence (2018) [Category] COVID19(2023년), [키워드] 2019-nCoV acute respiratory disease Australia Coronavirus disease 2019 COVID-19 Epidemiology novel coronavirus. SARS-CoV-2 [DOI] 10.33321/cdi.2022.46.73 PMC 바로가기
Preclinical findings: The pharmacological targets and molecular mechanisms of ferulic acid treatment for COVID-19 and osteosarcoma via targeting autophagyArticle Published on 2022-09-202022-11-15 Journal: Frontiers in Endocrinology [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] 2019 coronavirus disease activities acute respiratory disease applied autophagy Bioinformatics analysis characterized clinical coronavirus COVID-19 deficiency determine develop Effectiveness Evidence ferulic acid Genes impacted individuals MAPK1 mechanism mechanisms medication methodology molecular docking molecular docking analysis molecular mechanism network pharmacology number of infected Ontology osteosarcoma pandemic pathway enrichment Patient Patients with cancer pharmacological pharmacological target PIK3R1 Population potential therapeutic target Preclinical Protein regulatory subunit SARS-CoV-2 STAT3 target targets therapeutic therapeutic targets therapeutic targets. Transcription treat treatment for COVID-19 variant [DOI] 10.3389/fendo.2022.971687 PMC 바로가기
Proteomic Analysis Identifies Molecular Players and Biological Processes Specific to SARS-CoV-2 Exposure in Endothelial CellsArticle Published on 2022-09-092022-11-16 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory disease acute respiratory syndrome addition Analysis analyzed assays Biological Blood coagulation caused cell receptor cells cellular receptors changes in clinical manifestation coronavirus coronavirus disease correlated COVID-19 cytopathic effects damage different time points disease endothelial Endothelial cell endothelial cells Endothelial dysfunction Endothelium exposure expression help HUVECs identify immune response increase in Infection lack mass spectrometry Mild symptom molecular molecular mechanism oxidative stress pandemic pathway Protein proteome proteomic proteomics proteomics. responsible SARS-CoV-2 SARS-CoV-2 entry severe cases severe respiratory failure Specific SUMO2 thrombosis triggered umbilical Vascular [DOI] 10.3390/ijms231810452 PMC 바로가기
Presepsin Predicts Severity and Secondary Bacterial Infection in COVID-19 by Bioinformatics AnalysisArticle Published on 2022-09-062022-11-15 Journal: Computational and Mathematical Methods in Medicine [Category] SARS, 바이오마커, [키워드] acute respiratory disease Analysis AUC biological processes caused CD14 cellular components Coronavirus pneumonia COVID-19 COVID-19 patient Critical datasets deaths DEGs Diagnosis diagnostic value differentially expressed gene downregulated enrichment analysis expression function Gene ontology KEGG Kyoto limit majority moderate molecular function nonsurvivor novel novel coronavirus SARS-CoV-2 Pathway enrichment analysis PPI predict Prognosis protein-protein interaction screened secondary secondary bacterial infection selected severe COVID-19 severe COVID-19 patient severity significantly significantly higher significantly increased survivor Treatment upregulated utility was performed [DOI] 10.1155/2022/9914927 PMC 바로가기
Lower brachial artery flow-mediated dilation is associated with a worse prognosis and more lung parenchymal involvement in Covid-19: Prospective observational studyObservational Study Published on 2022-08-192022-10-05 Journal: Medicine [Category] 임상, [키워드] acute respiratory disease acute respiratory syndrome angiotensin-converting enzyme 2 Biochemical parameters brachial caused Coagulopathy coronavirus disease Coronavirus-2 cutoff point D-dimer Diagnosis died discharged disease Endothelial dysfunction endothelial function evaluate evaluated ferritin Hospitalized ICU ICU admission ICU patient intensive care investigated lactate dehydrogenase Lower lung lung involvement lung parenchyma moderate Mortality mortality rate multicenter negative correlation pandemic parenchymal pathogenic coronavirus patients patients hospitalized Prognosis Prospective prospective observational study receptor resulting risk factor shown significantly lower the patient vascular inflammation virus White blood cell worse prognosis [DOI] 10.1097/MD.0000000000030001 PMC 바로가기 [Article Type] Observational Study
Mucosal immunity: The missing link in comprehending SARS-CoV-2 infection and transmissionArticle Published on 2022-08-172022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] accumulating acquisition acute respiratory disease Administered aerosol antibody Antibody Response asymptomatic infection cause Community consequence Contact COVID COVID-19 demonstrated disease droplet explain helping humans immune system Immunoglobulin immunoglobulin A induce Infection initial intranasally limit lung mice Mild mucosal mucosal immune mucosal immunity mucosal secretion naïve subjects nasal fluid nasal passage Prevent protective immune response recall repeated response resulting Saliva SARS-CoV-2 SARS-COV-2 infection secretion secretory IgA SIgA Spread subjects suppress tonsil Transmission Transmission. upper respiratory upper respiratory tract Vaccine virus while [DOI] 10.3389/fimmu.2022.957107 PMC 바로가기
Anisodamine potently inhibits SARS-CoV-2 infection in vitro and targets its main protease아니소다민은 시험관 내에서 SARS-CoV-2 감염을 강력하게 억제하고 주요 프로테아제를 표적으로 합니다Article Published on 2022-08-062022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] Coronavirus, COVID19(2023년), SARS, 치료제, [키워드] active site acute respiratory disease acute respiratory syndrome acute respiratory syndrome coronavirus Amino acid amino acid residue analyzed Anisodamine Antiviral antiviral activity antiviral agent cells Chinese co-cultured coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cys145 disease docking score effective drug effective drugs Gly143 H-bond HEK293 immunofluorescence assay in vitro indicated Infection inhibit M pro main protease molecular docking molecular docking studies Molecular docking study pandemic predicted protease pseudovirus entry reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 suppressed target the SARS-CoV-2 therapeutic drug Traditional Chinese medicine treating COVID-19 Treatment treatment of COVID-19 Vero E6 VERO E6 cells viral infection Viral infection. [DOI] 10.1016/j.bbrc.2022.05.024 PMC 바로가기 [Article Type] Article
Coagulopathy in COVID-19 and anticoagulation clinical trialsReview article Published on 2022-08-012022-10-05 Journal: Best Practice & Research Clinical Haematology [Category] SARS, 바이오마커, 임상, [키워드] acute respiratory disease acute respiratory distress anticoagulation ARDS Asymptomatic CAC caused clinical trial Coagulopathy coronavirus COVID-19 COVID-19 patients develop Disseminated intravascular coagulation Endothelial cell Endotheliitis event feature form global pandemic infected with SARS-CoV-2 knowledge mechanism moderate NETs Other patients with moderate risk severe COVID-19 symptomatic syndrome thrombosis thrombotic event unique Wuhan, China [DOI] 10.1016/j.beha.2022.101377 [Article Type] Review article