The Phenomenon of Thrombotic Microangiopathy in Cancer PatientsReview Published on 2024-08-212024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] ADAMTS13 Cancer patients chemotherapy-induced TMA COVID-19 drug-induced TMA microangiopathic hemolytic anemia Thrombo-inflammation thrombotic microangiopathy Thrombotic thrombocytopenic purpura [DOI] 10.3390/ijms25169055 PMC 바로가기 [Article Type] Review
Practical Considerations for the Use of the Rapid AcuStar ® ADAMTS13 Activity Assay in the Diagnosis of Acute Thrombotic Thrombocytopenic Purpura (TTP)Article Published on 2024-07-302024-09-05 Journal: Journal of Clinical Medicine [Category] update2024, [키워드] ADAMTS13 Diagnosis ELISA enzyme assay Thrombotic thrombocytopenic purpura [DOI] 10.3390/jcm13154462 PMC 바로가기 [Article Type] Article
Increased Complement Activation and Decreased ADAMTS13 Activity Are Associated with Genetic Susceptibility in Patients with Preeclampsia/HELLP Syndrome Compared to Healthy Pregnancies: An Observational Case-Controlled StudyArticle Published on 2024-04-032024-09-05 Journal: Journal of Personalized Medicine [Category] update2024, [키워드] ADAMTS13 C5b-9 complement system HELLP syndrome Next-generation sequencing preeclampsia pregnancy-associated liver disease [DOI] 10.3390/jpm14040387 PMC 바로가기 [Article Type] Article
Decreased protein C activity, lower ADAMTS13 antigen and free protein S levels accompanied by unchanged thrombin generation potential in hospitalized COVID-19 patientsFull Length Article Published on 2023-01-242024-09-05 Journal: Thrombosis research [Category] update2024, [키워드] ADAMTS13 COVID-19 Free protein S protein C Thrombin generation [DOI] 10.1016/j.thromres.2023.01.016 PMC 바로가기 [Article Type] Full Length Article
Prognostic value of von Willebrand factor and ADAMTS13 in patients with COVID-19: A systematic review and meta-analysisReview article Published on 2022-10-012022-10-05 Journal: Thrombosis research [Category] 바이오마커, 진단, [키워드] ADAMTS13 addition Admission Analysis analyzed Antigen cause cleaving Clinical outcome Coagulation Coagulopathy Cochrane Library cofactor coronavirus disease COVID-19 COVID-19 patient Critical database death deficiency defined Effect endothelial injury estimate fixed FVIII ICU immunothrombosis increase indicated intensive care involved Ligand Meta-analysis metalloproteinase Mortality motif no significant difference non-ICU non-survivor outcome outcomes Patient patients with COVID-19 performed plasma poor prognosis Prognosis protease Quantitative random Result risk SARS-CoV-2 searched severe disease course subgroup analysis survivor Survivors systematic review the Newcastle-Ottawa Scale variable von Willebrand factor vWF Web of Science [DOI] 10.1016/j.thromres.2022.08.017 [Article Type] Review article
Proteomic analysis of cardiometabolic biomarkers and predictive modeling of severe outcomes in patients hospitalized with COVID-19심장대사 바이오마커의 단백질체 분석 및 COVID-19로 입원한 환자의 심각한 결과 예측 모델링Article Published on 2022-07-212022-09-11 Journal: Cardiovascular Diabetology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] accelerate ACE2 ADAMTS13 Admission Analysis association Biomarker Biomarkers cardiometabolic Cardiometabolic biomarkers cardiometabolic disease Care circulating Clinical data collected Comorbidity COVID-19 COVID-19 severity death First wave heterogeneity high-risk patient High-risk patients higher risk identify IL-1ra IL6 implicated intensive care intensive care unit likelihood lower risk outcome outcomes pandemic Patient patients patients hospitalized performed plasma sample plasma samples predict Predictive Predictive model Predictive modeling predictive models Protein proteomic Proteomic analysis proteomics Recognition Risk factors Seven severe COVID-19 severity severity of COVID-19 shown susceptible Symptom the disease Treatment VEGFD with COVID-19 [DOI] 10.1186/s12933-022-01569-7 PMC 바로가기 [Article Type] Article
Carriers of ADAMTS13 Rare Variants Are at High Risk of Life-Threatening COVID-19ADAMTS13 희귀 변이의 보균자는 생명을 위협하는 COVID-19의 위험이 높습니다Article Published on 2022-05-292022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ADAMTS13 Add-on therapy age aggregation Analysis Asymptomatic autosomal dominant autosomal dominant disorder autosomal recessive autosomal recessive disorder binding caplacizumab carrier carriers characterized cleaving Cohort conditioned congenital COVID-19 COVID-19 severity crizanlizumab disintegrin disorder drug enzyme Families GEN-COVID genetic determinant heterozygous state Host hyper-inflammation infections inhibit inhibiting Interaction large vessel leukocyte ligands motif P-selectin Platelet platelet aggregation Prevent recruitment reported SARS-CoV-2 infected subject SARS-COV-2 infection selectin Sex susceptibility thrombocytopenic purpura Thromboembolism thrombosis thrombotic thrombotic microangiopathy Thrombotic thrombocytopenic purpura triggered variant Vascular damage [DOI] 10.3390/v14061185 PMC 바로가기 [Article Type] Article
Plasma Proteomics of COVID-19–Associated Cardiovascular Complications: Implications for Pathophysiology and TherapeuticsResearch article Published on 2022-05-012022-10-05 Journal: JACC: Basic to Translational Science [Category] 바이오마커, 유전자 메커니즘, [키워드] ADAMTS13 cardiovascular cardiovascular complication Case-control cause Cohort COVID-19 COVID-19 patient COVID-19 patients disease severity dominant driving finding FSTL3 identify Implications Injury loss-of-function marker mechanism Microvascular thrombosis Myocardial myocardial injury pathophysiology performed phenotype plasma proteomics protease Protein proteomics senescence Signaling Stress therapeutic Therapeutics [DOI] 10.1016/j.jacbts.2022.01.013 [Article Type] Research article
The role of lipoprotein(a) in coronavirus disease 2019 (COVID-19) with relation to development of severe acute kidney injury중증 급성 신장 손상의 발병과 관련하여 2019년 코로나바이러스(COVID-19)에서 지단백질(a)의 역할Observational Study Published on 2022-04-012022-09-11 Journal: Journal of Thrombosis and Thrombolysis [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, [키워드] acute kidney failure Acute kidney injury ADAMTS13 Admission adverse outcome adverse outcomes Biomarkers Coagulopathy Concentration controls coronavirus coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 COVID-19 illness COVID-19 patient COVID-19 patients creatinine defined disease disease severity elevations fibrinogen IL-6 Inflammation interleukin kidney Kidney failure lipoprotein Lipoprotein(a) observational study outcome Pathogenesis patients with COVID-19 positively correlated prospective observational study prothrombotic serum severity severity of COVID-19 sick significantly thrombosis were measured [DOI] 10.1007/s11239-021-02597-y PMC 바로가기 [Article Type] Observational Study
Reduced ADAMTS13 Activity in Correlation with Pathophysiology, Severity, and Outcome of COVID-19: A Retrospective Observational StudyObservational Study Published on 2022-04-012022-10-05 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 바이오마커, 변종, 임상, [키워드] 95% CI Abu activity ADAMTS13 Anticoagulant Anticoagulants anticoagulation carried Characteristics clinical outcomes correlation COVID-19 COVID-19 severity Cytokine storm Decreased disease high risk inflammatory markers mechanical ventilation Mortality pathogenesis of COVID-19 pathophysiological pathway Patient patients patients with COVID-19 Pneumonia retrospective risk SARS-CoV-2 severe COVID-19 severity of COVID-19 statistically significant suggested thrombosis Treatment viral clearance was measured [DOI] 10.1016/j.ijid.2022.02.019 PMC 바로가기 [Article Type] Observational Study