A two-dose viral-vectored Plasmodium vivax multistage vaccine confers durable protection and transmission-blockade in a pre-clinical studyarticle Published on 2024-04-302024-09-01 Journal: Frontiers in immunology [Category] 말라리아, [키워드] adeno-associated virus LC16m8Δ malaria Plasmodium vivax PvCSP Pvs25 Vaccine [Article Type] article
Delivery of DNA-Based Therapeutics for Treatment of Chronic DiseasesReview Published on 2024-04-132024-09-05 Journal: Pharmaceutics [Category] update2024, [키워드] AAV adeno-associated virus chronic disease DNA medicine Electroporation Gene therapy plasmid DNA [DOI] 10.3390/pharmaceutics16040535 PMC 바로가기 [Article Type] Review
Preexisting antibody assays for gene therapy: Considerations on patient selection cutoffs and companion diagnostic requirementsReview Published on 2024-02-202024-09-05 Journal: Molecular Therapy [Category] update2024, [키워드] adeno-associated virus clinical decision limit companion diagnostic diagnostic assay strategy Gene therapy in vitro diagnostic regulations patient selection Preexisting antibodies reference limit risk-benefit assessment [DOI] 10.1016/j.omtm.2024.101217 PMC 바로가기 [Article Type] Review
PCR-based analytics of gene therapies using adeno-associated virus vectors: Considerations for cGMP method developmentReview Published on 2023-10-272024-09-05 Journal: Molecular Therapy [Category] update2024, [키워드] adeno-associated virus artificial intelligence droplet digital PCR Gene therapy good manufacturing practices Next-generation sequencing quantitative PCR Regulatory [DOI] 10.1016/j.omtm.2023.101132 PMC 바로가기 [Article Type] Review
In vivo genome editing using 244- cis LNPs and low-dose AAV achieves therapeutic threshold in hemophilia A miceOriginal Article Published on 2023-10-072024-09-05 Journal: Molecular Therapy. Nucleic Acids [Category] update2024, [키워드] adeno-associated virus CRISPR-Cas9 Genome editing hemophilia A Lipid nanoparticle low-dose virus MT: RNA/DNA Editing [DOI] 10.1016/j.omtn.2023.102050 PMC 바로가기 [Article Type] Original Article
Liver-Humanized NSG-PiZ Mice Support the Study of Chronic Hepatitis B Virus Infection and Antiviral Therapiesarticle Published on 2023-05-182024-09-05 Journal: Microbiology Spectrum [Category] update2024, [키워드] adeno-associated virus cccDNA Engraftment Hepatitis B virus hepatocyte RTi [DOI] 10.1128/spectrum.05176-22 PMC 바로가기 [Article Type] article
Delivery Platforms for Broadly Neutralizing AntibodiesArticle Published on 2023-05-112024-09-05 Journal: Current opinion in HIV and AIDS [Category] update2024, [키워드] adeno-associated virus B cell editing broadly neutralizing antibodies Broadly neutralizing antibody DNA Delivery DNA-based therapies HIV mRNA mRNA-based therapies Vectored ImmunoProphylaxis [DOI] 10.1097/COH.0000000000000803 PMC 바로가기 [Article Type] Article
Generation and Characterization of a SARS-CoV-2-Susceptible Mouse Model Using Adeno-Associated Virus (AAV6.2FF)-Mediated Respiratory Delivery of the Human ACE2 GeneArticle Published on 2022-12-282023-07-11 Journal: Viruses [Category] COVID19(2023년), [키워드] adeno-associated virus Angiotensin-converting enzyme 2 (ACE2) animal model COVID-19 host specificity Infection mouse model pandemic SARS-CoV-2 species specificity Virology [DOI] 10.3390/v15010085 PMC 바로가기
Rational design of AAVrh10-vectored ACE2 functional domain to broadly block the cell entry of SARS-CoV-2 variantsSARS-CoV-2 변이체의 세포 진입을 광범위하게 차단하기 위한 AAVrh10 벡터화 ACE2 기능 도메인의 합리적인 설계Article Published on 2022-09-012022-09-11 Journal: Antiviral Research [Category] Coronavirus, COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 ortholog ACE2 orthologs adeno-associated virus Adeno-associated virus (AAV) vector amino acids angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 breadth Candidates cell entry comprehensive analysis COVID-19 COVID-19 vaccine domain Effectiveness Ex vivo exhibited fragment of functional higher affinity human ACE2 in silico in vitro Infection Interaction neutralizing antibody Protein RBD Receptor binding domain sACE2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants serotype the RBD therapeutic strategy therapy These data tissue tropism variant variants virus was performed weakened [DOI] 10.1016/j.antiviral.2022.105383 PMC 바로가기 [Article Type] Article
High activity of an affinity-matured ACE2 decoy against Omicron SARS-CoV-2 and pre-emergent coronavirusesOmicron SARS-CoV-2 및 사전 출현 코로나바이러스에 대한 친화성 성숙 ACE2 유인물의 높은 활성Article Published on 2022-08-252022-09-11 Journal: PLoS ONE [Category] SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adeno-associated virus affinity airway angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antigenic antigenic drift binding can not clade complicate coronavirus coronavirus disease Coronavirus disease 2019 Coronaviruses COVID-19 COVID-19 pandemic decoy develop drug Efficacy Evolution exceptional genetic diversity human ACE2 inhibitor intranasal intrinsic mitigate monoclonal antibody mutant nanomolar affinity Neutralizing omicron pandemic populations preparation Prophylaxis receptor Receptor-binding domain sarbecovirus Sarbecoviruses SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Spike protein the SARS-CoV-2 the spike protein therapeutic Threats Treatment Vaccine variant variants viral evolution viral genome viral spike viral strain viral strains virus widespread zoonotic [DOI] 10.1371/journal.pone.0271359 PMC 바로가기 [Article Type] Article