Adhesion Molecule – Communicable Diseases Research

Host susceptibility genes of asymptomatic malaria from South Central Timor, Eastern Indonesia

article

Published on 2023-01-312024-09-01
Journal: Parasitology Research [Category] 말라리아,

Differences and similarities in endothelial and angiogenic profiles of preeclampsia and COVID-19 in pregnancy

임신 중 자간전증 및 COVID-19의 내피 및 혈관 신생 프로파일의 차이 및 유사성

Article

Published on 2022-08-012022-08-31
Journal: American journal of obstetrics and gynecology [Category] MERS, 바이오마커, 진단,

[키워드] absence activate addition Adhesion Molecule alteration Analysis Angiogenesis angiogenic factors angiopoietin Antigen Biomarker Biomarkers C5b9 Cell cell membrane cell membranes Cell signaling change changes in circulating Coagulation Coagulopathy component Concentration Control controls COVID-19 COVID-19 infection COVID-19 patients Culture demonstrated difference differential diagnosis differentiation disease disorder endothelial Endothelial cell endothelial cells endothelial damage Endothelial dysfunction evaluated exhibited expected explained expression Extracellular Extracellular matrix group growth growth factor healthy heparan sulfate hypertensive hypertensive disorders of pregnancy Immunoblots immunofluorescence in some in vitro increase in Infection Inflammation inflammatory signaling innate immune response intercellular intercellular adhesion molecule less lysate lysates Mild mitogen-activated protein kinase Necrosis neutrophil Neutrophil extracellular trap Neutrophil extracellular traps normotensive overexpression Pathways Patient Phosphorylation placental placental growth factor preeclampsia Pregnancy pregnant women Principal component principal component analysis profile profiles Protein protein kinase receptor reduced reduction reduction in SARS-CoV-2 sera severe COVID-19 severe COVID-19 patient signaling pathway significant increase significantly increased Signs and symptoms similarity soluble fms-like tyrosine kinase-1 soluble tumor necrosis factor-α receptor I Spectrum statistical analysis statistically Study design sulfate Symptom Tumor tumor necrosis tumor necrosis factor-α tyrosine variable variance vascular cell adhesion von Willebrand disease von Willebrand factor with COVID-19 women
[DOI] 10.1016/j.ajog.2022.03.048 PMC 바로가기 [Article Type] Article

Reveal the Mechanisms of Yi-Fei-Jian-Pi-Tang on Covid-19 through Network Pharmacology Approach

네트워크 약리학 접근법을 통해 Covid-19에 대한 Yi-Fei-Jian-Pi-Tang의 메커니즘 공개

Article

Published on 2022-07-162022-09-11
Journal: Computational Intelligence and Neuroscience [Category] 유전자 메커니즘,

[키워드] activated activator Adhesion Molecule AKT AKT1 Alpha Beta binding C-C motif chemokine ligand C-C motif chemokine ligand 2 cancers CASP8 caspase caspase 8 CCL2 chemokine Chinese contribute Corona Critical CXCL8 Cytoscape database demonstrated effective EGFR enhancer enrichment analysis epidermal epidermal growth factor ERBB2 Formula foundation Gene ontology genomes growth factor Herb HIF1a HMOX1 hypoxia ICAM1 IL10 IL1A IL1B IL2 IL4 IL6 ingredient inhibitor inquiry intercellular intercellular adhesion molecule interferon gamma interleukin interleukin 2 Interleukin 4 interleukin 6 JUN KEGG Kyoto Ligand MAPK3 MAPK8 mechanism Medicine mitogen-activated protein kinase MMP1 MMP3 motif MPO myeloperoxidase Necrosis network network pharmacology NFE2 NFE2L2 NFkB NFKBIA nitric oxide nitric oxide synthase NOS3 nuclear oncogene outcome p53 pathway Pathways Patient Pharmacology PPARA Protein protein kinase protein p53 protein-protein interaction receptor RELA Research Serine Stat1 STRING database subunit target target protein targets TCM TGFB1 therapeutic target threonine Timp1 TNF TP53 Traditional Traditional Chinese medicine Transcription transcription factor transforming growth factor Tumor tumor necrosis tumor necrosis factor tyrosine UniProt Virus Disease
[DOI] 10.1155/2022/1493137 PMC 바로가기 [Article Type] Article

Whole-genome sequencing reveals host factors underlying critical COVID-19

전체 게놈 시퀀싱은 중요한 COVID-19의 기저에 있는 숙주 요인을 밝힙니다

Article

Published on 2022-07-012022-09-11
Journal: Nature [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 임상, 진단, 치료기술, 치료제,

[키워드] Adhesion Molecule Antigen association associations ATP11A BCL11A caused CD209 Coagulation coagulation factor Colocalization Control COVID-19 Critical Critical care Critical disease Critical illness Critically ill disease disease severity Evidence expression Factor failure FUT2 Gene Expression Genetic variation genetics Genome genomes GenOMICC Hospitalization Host ICAM5 identify IL10RB Immune-mediated increased expression independent individual infection with SARS-CoV-2 inflammatory lung injury influence interferon intravascular coagulation involved leucocyte life-threatening Lung injury mechanism mechanisms membrane mendelian randomization MUC1 mucin myeloid cell pathophysiology PLSCR1 provide pulmonary inflammation reduced replicate reveal SELE Sequencing significantly Support targets transcriptome-wide underlying disease variant variants Viral viral replication whole-genome sequencing
[DOI] 10.1038/s41586-022-04576-6 PMC 바로가기 [Article Type] Article

Mediators of Obesity Do Not Influence SARS-CoV-2 Infection or Activation of Primary Human Lung Microvascular Endothelial Cells In Vitro

비만 매개체는 SARS-CoV-2 감염 또는 시험관 내 1차 인간 폐 미세혈관 내피 세포 활성화에 영향을 미치지 않습니다

Article

Published on 2022-06-282022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술,

[키워드] activated Activation addition Adhesion Molecule adipokines adipose Adipose tissue Alter Cell cells clinical clinical observations COVID-19 Critically ill driving dysfunction E-selectin endothelial endothelial activation Endothelial cell endothelial cells Endothelial dysfunction evidenced exacerbate excess exposure to expression fat Human human lung ICAM-1 IL-6 Incubation individuals induce Infection Inflammation Inflammatory Inflammatory cytokine Inflammatory response Inflammatory responses influence initiated lack Leptin lung Lungs mechanism mediator mounted obese obese COVID-19 patients obesity observation other organs outcome phenotype plasma pro-inflammatory produced virus required response SARS-CoV-2 SARS-CoV-2 entry receptor SARS-COV-2 infection selectin severe disease shown susceptibility susceptibility to infection susceptible systemic level tested tissue VCAM-1 Viral protein Viral proteins virus visceral with COVID-19
[DOI] 10.3389/fimmu.2022.879033 PMC 바로가기 [Article Type] Article

HIV protease inhibitors Nelfinavir and Lopinavir/Ritonavir markedly improve lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effect

HIV 프로테아제 억제제 Nelfinavir 및 Lopinavir/Ritonavir는 항바이러스 효과가 없음에도 불구하고 SARS-CoV-2에 감염된 시리아 햄스터의 폐 병리를 현저하게 개선합니다

Article

Published on 2022-06-012022-09-11
Journal: Antiviral Research [Category] COVID19(2023년), SARS, 진단, 치료제,

[키워드] accompanied activated neutrophil Activated neutrophils Adhesion Molecule adhesion molecules Alter Antiretroviral therapy antiviral activity Antiviral effect appear Blood Combination component CXCL8 did not reduce expression hamster hamsters highly active HIV HIV protease inhibitor human neutrophil human neutrophils immunomodulatory effect IMPROVE in vitro increase in independent independent of induce Infectious virus infiltration of neutrophil infiltration of neutrophils interstitium lack Lopinavir Lopinavir/ritonavir lung Lung pathology Migration nelfinavir neutrophil Neutrophils non-infected Protease inhibitor protease inhibitors protective effect receptor reported Ritonavir SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 titre Treatment treatment of HIV Viral viral RNA load
[DOI] 10.1016/j.antiviral.2022.105311 PMC 바로가기 [Article Type] Article

Opposing roles for sMAdCAM and IL-15 in COVID-19 associated cellular immune pathology

COVID-19 관련 세포 면역 병리학에서 sMAdCAM 및 IL-15의 반대 역할

Article

Published on 2022-06-012022-09-11
Journal: Journal of leukocyte biology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] Activation Adhesion Molecule association Asymptomatic Asymptomatic cases CD4+ CD8 Cell cell adhesion molecule cellular characterized circulating Cohort correlated COVID COVID-19 COVID-19 pathology cytokine disease Disease progression duration of hospitalization dysfunction dysregulation effector memory ELISA evaluated Factors flow cytometry Frequency healthy control healthy controls homeostasis homeostatic hypoxemic IL-15 IL-6 IL-6 level IL-6 levels immune increase in India infected individuals Inflammatory factor inflammatory factors intermediate monocytes involved lymphocyte lymphopenia marker Mild moderate moderate to severe monocyte Monocytes mucosal multiparametric flow cytometry Mumbai Pathogenesis pathology plasma profiles quantified recruited regulatory T cells SARS-CoV-2 SARS-CoV-2 infected individual SARS-CoV-2 infected individuals severe disease sMAdCAM. Stage subset symptomatic individual symptomatic individuals symptomatic infection T cells was used while
[DOI] 10.1002/JLB.3COVBCR0621-300R PMC 바로가기 [Article Type] Article

Inhibitory effects and mechanisms of the anti-covid-19 traditional Chinese prescription, Keguan-1, on acute lung injury

급성 폐 손상에 대한 항 코비드 -19 전통 중국 처방, Keguan-1의 억제 효과 및 메커니즘

Article

Published on 2022-03-012022-08-31
Journal: Journal of ethnopharmacology [Category] MERS, SARS, 비임상, 치료제,

[키워드] acute lung injury Adhesion Molecule Administered administration ALI Alpha ameliorated analysed Ang II Angiotensin II ARDS BALF breath cadherin chemokine Chinese claudin Clinical treatment clinical trial collected coronavirus coronavirus disease COVID-19 demonstrated Diseases Effect ELISA Emerging infectious diseases Endothelial cell endothelial injury expression Factor High dose ICAM-1 IL-1β IL-6 IMPROVE incidence Infectious diseases Inflammation Inflammatory Inflammatory factor inflammatory factors inflammatory protein inhibited Injury interleukin intratracheal instillation Keguan-1 keratinocyte lipopolysaccharide low dose LPS lung Lung injury lung tissue lung tissues Macrophage material mechanism medium dose mice Necrosis neutrophil Neutrophils patients with COVID-19 progression proinflammatory protective mechanism Protein provide pulmonary Pulmonary vascular endothelial injury. randomised reduced reducing Registered Seven significantly Support survival rate TCM therapy tight junction TNF-α Traditional Chinese medicine treat Tumour necrosis factor alpha Vascular VE-cadherin was used western blotting
[DOI] 10.1016/j.jep.2021.114838 PMC 바로가기 [Article Type] Article

The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling

SARS-CoV-2의 스파이크 단백질은 인테그린 α5β1 및 NF-κB 신호 전달을 통해 내피 염증을 유도합니다

Article

Published on 2022-03-012022-09-11
Journal: The Journal of Biological Chemistry [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] ACE2 activate Activation addition adhesion Adhesion Molecule administration bind Blood Capillaries CD45 Coagulation coagulation factor Coagulation factors COVID-19 Critical Cytokines dependent on domain dysfunction dysregulated edema Effects endothelial Endothelial cell endothelial cells Endothelial dysfunction expression FVIII hallmark hallmarks homeostasis ICAM1 IL-1β IL-6 in vivo increased expression Incubation induce Inflammation inflammatory phenotype inhibitor inhibitors integrin intravenous Intravenous administration intravitreal injection kidney leukocyte leukocytes liver lung maintain mechanism motif NF-κB NF-κB signaling nuclear translocation occur Peripheral blood peripheral blood leukocyte peripheral blood leukocytes permeability prevented Proinflammatory cytokine proinflammatory cytokines Receptor-binding domain responsible SARS-CoV-2 severe disease Signaling Spike protein spike protein of SARS-CoV-2 subsequent target gene the receptor-binding domain the spike protein tissue tissues TNFα umbilical umbilical vein vascular effect vascular endothelial cells vascular inflammation vascular leakage VCAM1
[DOI] 10.1016/j.jbc.2022.101695 PMC 바로가기 [Article Type] Article

Elevated plasma levels of epithelial and endothelial cell markers in COVID-19 survivors with reduced lung diffusing capacity six months after hospital discharge

병원 배출 6 개월 후 폐 확산 능력 감소 된 Covid-19 생존자에서 상피 및 내피 세포 마커의 혈장 수준 증가

Observational Study

Published on 2022-02-212022-09-01
Journal: Respiratory Research [Category] MERS, 바이오마커, 임상, 진단,

[키워드] abnormality acute disease acute respiratory distress acute respiratory distress syndrome Adhesion Molecule angiopoietin ARDS carbon monoxide Cell Characteristics circulating clinical Clinical characteristics COVID-19 diffusing diffusing capacity discharge disease DLCO Dyspnoea E-selectin elevated endothelial Endothelial cell endothelial marker Endothelial markers epithelial Epithelial markers Follow-up hospital discharge Hospitalization hypertension independent risk factor independent risk factors individuals intercellular intercellular adhesion molecule leukocyte Level lung lung damage Lung function marker multivariate regression analysis observational study Occurrence Older Organizing pneumonia pathophysiology Patient patients plasma Plasma levels Pneumonia Post-COVID Prospective Protease inhibitor Protein Pulmonary embolism pulmonary embolisms reduced respiratory distress Result risk factor Risk factors selectin Sequelae severe COVID-19 severity Severity Score SLPI Smokers spirometry suffered supplementary material survivor Survivors syndrome
[DOI] 10.1186/s12931-022-01955-5 PMC 바로가기 [Article Type] Observational Study