Mutation of a highly conserved isoleucine residue in loop 2 of several β -coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental to infectionArticle Published on 2024-07-122024-09-05 Journal: bioRxiv [Category] update2024, [키워드] ADP-ribosylation ADP-ribosylhydrolase coronavirus interferon macrodomain MERS-CoV MHV non-structural protein 3 SARS-CoV-2 [DOI] 10.1101/2024.01.03.574082 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in miceBiological Sciences Published on 2023-08-222024-09-05 Journal: Proceedings of the National Academy of Sciences of [Category] update2024, [키워드] ADP-ribosylation coronavirus interferon macrodomain SARS-CoV-2 [DOI] 10.1073/pnas.2302083120 PMC 바로가기 [Article Type] Biological Sciences
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in miceArticle Published on 2023-04-062024-09-05 Journal: bioRxiv [Category] update2024, [키워드] ADP-ribosylation coronavirus Cytokines inflammatory monocytes Innate immunity interferon macrodomain non-structural proteins SARS-CoV-2 [DOI] 10.1101/2023.04.06.535927 PMC 바로가기 [Article Type] Article
Protein post-translational modification in SARS-CoV-2 and host interactionReview Published on 2023-01-132024-09-05 Journal: Frontiers in immunology [Category] update2024, [키워드] acylation ADP-ribosylation glycosylation Methylation Phosphorylation SARS-CoV-2 ubiquitination [DOI] 10.3389/fimmu.2022.1068449 PMC 바로가기 [Article Type] Review
Binding Adaptation of GS-441524 Diversifies Macro Domains and Downregulates SARS-CoV-2 de-MARylation CapacityArticle Published on 2022-08-302023-07-10 Journal: Journal of Molecular Biology [Category] COVID19(2023년), [키워드] ADP-ribosylation alphaviruses Coronaviruses Macro domain PARPs Remdesivir [DOI] 10.1016/j.jmb.2022.167720 PMC 바로가기
Design, synthesis and evaluation of inhibitors of the SARS-CoV-2 nsp3 macrodomainArticle Published on 2022-08-012023-07-09 Journal: Bioorganic & Medicinal Chemistry [Category] COVID19(2023년), [키워드] ADP-ribosylation coronavirus COVID-19 Nsp3 macrodomain inhibitors SARS-CoV-2 [DOI] 10.1016/j.bmc.2022.116788 PMC 바로가기
Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screeningArticle Published on 2022-07-012023-07-09 Journal: Antiviral Research [Category] COVID19(2023년), [키워드] ADP-ribose ADP-ribosylation coronavirus High-throughput screening macrodomain SARS-CoV-2 [DOI] 10.1016/j.antiviral.2022.105344 PMC 바로가기
Intracellular mono-ADP-ribosyltransferases at the host–virus interphaseReview Published on 2022-05-102023-08-30 Journal: Cellular and Molecular Life Sciences [Category] E형 간염, [키워드] ADP-ribosylation alphavirus Chikungunya virus coronavirus hydrolase interferon macrodomain MARylation PARP Pattern recognition receptors Signaling [DOI] 10.1007/s00018-022-04290-6 PMC 바로가기 [Article Type] Review
The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and AlphavirusesPerspective Published on 2022-01-142022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acting addition ADP-ribosylation ADP-ribosylhydrolase alphavirus Antiviral Antiviral agents antiviral target antivirals approaches binding pocket combating Combination combination therapy complement conserved Coronaviral coronavirus Coronaviruses COVID-19 COVID-19 pandemic Critical demonstrated develop drug target effective Host inhibitor interferon interferon response lack macrodomain Mutation offer pandemic Pathogenesis Potential protease Protective public health Replication responses RNA polymerase SARS-CoV-2 suppresse target targets Therapeutics Threats Treatment Vaccines viral disease Viral macrodomain virus virus replication [DOI] 10.3390/pathogens11010094 PMC 바로가기 [Article Type] Perspective
Computational Analysis of Missense Variants in the Human Transmembrane Protease Serine 2 ( TMPRSS2 ) and SARS-CoV-2Research Article Published on 2021-10-192022-10-27 Journal: BioMed Research International [Category] COVID-19, MERS, [키워드] 3D structure activating acute respiratory syndrome ADP-ribosylation association cleaving conserved ConSurf coronavirus decrease Deleterious deleterious effect Effect evaluated facilitate Human identify missense variant mutant posttranslational modification progression Prostate cancer protease Protein proteolytic cleavage PROVEAN Ramachandran plot SARS-CoV-2 serine 2 SIFT stability susceptibility target cell tested the S protein TMPRSS2 transmembrane variant viral entry [DOI] 10.1155/2021/9982729 PMC 바로가기 [Article Type] Research Article