Thymic function and survival at advance ages in nursing home residents from Southern Italyarticle Published on 2023-04-102024-09-05 Journal: Immunity & Ageing : I & A [Category] update2024, [키워드] advanced age C-reactive protein (CRP) Immunoageing immunosenescence Mortality nursing home survival T-cell receptor rearrangement excision circles (sjTRECs) thymus [DOI] 10.1186/s12979-023-00340-0 PMC 바로가기 [Article Type] article
Identification of CKD, bedridden history and cancer as higher-risk comorbidities and their impact on prognosis of hospitalized Omicron patients: a multi-centre cohort studyArticle Published on 2022-12-012022-11-16 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 치료기술, [키워드] advanced age age Cancer China Chronic kidney disease CKD cohort study Comorbidity condition conditions COVID-19 critical cases enrolled Factor female first positive hospialized population Hospitalized hospitalized patient hypertension identification Logistic regression Metabolic disorders multivariate Observational cohort study omicron participant Patient patients Primary outcome Prognosis progression risk factor Risk factors SARS-CoV-2 SARS-CoV-2 detection secondary outcome severity Shanghai suggested vaccination viral shedding [DOI] 10.1080/22221751.2022.2122581 PMC 바로가기
SARS-CoV-2 Spike-Binding Antibody Longevity and Protection from Reinfection with Antigenically Similar SARS-CoV-2 VariantsArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome advanced age analyzed antibodies antibody antibody durability Antibody titer circulation Cohort collected convalescent coronavirus coronavirus disease COVID-19 decrease detectable determine Effectiveness Enrollment exceptional female Health care worker highlight immune responses Increases Infection initial limit Longevity median modeling mounted new SARS-CoV-2 occurred Pandemics participant Participants protection public health crisis Rapid Reinfection risk SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 variant seronegative seropositive seropositive participant severe COVID-19 Sex spike-binding antibodies. stability Steady state vaccination variants of concern viruses [DOI] 10.1128/mbio.01784-22 PMC 바로가기
A multinational, phase 2, randomised, adaptive protocol to evaluate immunogenicity and reactogenicity of different COVID-19 vaccines in adults ≥75 already vaccinated against SARS-CoV-2 (EU-COVAT-1-AGED): a trial conducted within the VACCELERATE networkArticle Published on 2022-10-082022-11-15 Journal: Trials [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ≥75 years. adaptive addition advanced age age Analysis Antibody titre benefit BNT162b2 BNT162b2 (Comirnaty®) booster booster dose changes in Clinical course collected concern conducted COVID-19 COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine dose Endpoint enzyme-linked immunosorbent evaluate exploratory fourth dose humoral immune response immunosenescence include individual initial Intervention mRNA-1273 mRNA-1273 (Spikevax®) multicentre neutralising neutralising antibody titre Older Part Patient performed phase phase II primary endpoint protocol qPCR Quantitative randomisation randomised randomised controlled reactogenicity Research risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine secondary subgroup T cell response the primary endpoint Trial triggered vaccination Vaccine vaccine-induced immune response variants variants of concern VoC wild-type wild-type virus [DOI] 10.1186/s13063-022-06791-y PMC 바로가기
Adverse events following immunization of elderly with COVID-19 inactivated virus vaccine (CoronaVac) in Southeastern Brazil: an active surveillance studyArticle Published on 2022-10-032022-11-15 Journal: Revista do Instituto de Medicina Tropical de São [Category] 진단, [키워드] Active surveillance Administered advanced age Adverse adverse event Brazil center chronic conditions collected Comorbidities Contact CoronaVac COVID-19 vaccine daily living dose doses eight enrolled evaluate event fatigue female frailty headache Healthcare workers home immunization impairment inactivated Inactivated vaccine information injection Mild moderate MOST myalgia participant Population public health receive reference reported Safe severe adverse events team the vaccine vaccination vaccination schedule Vaccine vaccine dose virus with COVID-19 [DOI] 10.1590/S1678-9946202264056 PMC 바로가기
Advanced age, comorbidity and the risk of mortality in COVID-19 infectionArticle Published on 2022-10-012023-07-09 Journal: Journal of the National Medical Association [Category] COVID19(2023년), [키워드] advanced age Comorbidity COVID-19 Mortality Safety-net hospital. [DOI] 10.1016/j.jnma.2022.06.005 PMC 바로가기
Severe Pancytopenia After COVID-19 Revealing a Case of Primary Bone Marrow Diffuse Large B Cell LymphomaArticle Published on 2022-09-242022-11-15 Journal: The American journal of case reports [Category] SARS, 진단, [키워드] abdominal pain absence advanced age Anemia anorexia Antibiotics B cell Blood bone Bone marrow Cell Chemotherapy Clinical deterioration Combination COVID-19 Culture Cyclophosphamide Diagnosis diarrhea died diffuse DLBCL Doxorubicin elevated fatigue Fever G-CSF granulocyte IMPROVE Infection inflammation markers initiated lymphoma malignancy management Marrow NHL Non-Hodgkin Lymphoma Pancytopenia Patient patient with COVID-19 PCR Platelet positive Prednisone Prognosis rituximab Thoracic tomography Treatment vincristine watery weight loss while White blood cell worsening [DOI] 10.12659/AJCR.937500 PMC 바로가기
Predictors of poor serologic response to COVID-19 vaccine in patients with cancer: a systematic review and meta-analysisResearch article Published on 2022-09-012022-10-05 Journal: European journal of cancer (Oxford, England : 1990 [Category] 변종, [키워드] 95% confidence interval advanced age anti-CD20 therapy article Cancer Cancer patients cancer treatment Chemotherapy China cohort study Complete Concentration correlated Course COVID-19 vaccination COVID-19 vaccine database Endocrine Factor heterogeneity Immunotherapy inclusion criteria Infrastructure item male Meta-analysis metastatic disease Mutation no significant difference Odds ratio outcome Patient patients Patients with cancer predict predictor predictors Probability receiving Registered Relating reported Reporting Result review searched Seroconversion Serologic response statistical systematic review Treatment vaccination Vaccination strategy was used [DOI] 10.1016/j.ejca.2022.05.031 [Article Type] Research article
Impact of diabetes on COVID-19 prognosis beyond comorbidity burden: the CORONADO initiativeClinical Trial Published on 2022-09-012022-10-05 Journal: Diabetologia [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 adjusted Admission advanced age age Analysis Aspartate aminotransferase BMI C-reactive protein Charlson index Clinical outcome cohort study Comorbidities Comorbidity component coronavirus disease COVID-19 COVID-19 prognosis COVID-19 symptom death Deleterious diabete diabetes disease Dyspnoea French higher risk hospital Hospital admission Impact IMV individual Invasive mechanical ventilation multivariable analysis occurred participant Patient performed Platelet primary composite endpoint primary endpoint Prognosis Prognostic factor question remained risk risk factor risk of death SARS-CoV-2 Sex variable white cell with COVID-19 women [DOI] 10.1007/s00125-022-05734-1 PMC 바로가기 [Article Type] Clinical Trial
Thrombotic and bleeding complications in patients with chronic lymphocytic leukemia and severe COVID-19: a study of ERIC, the European Research Initiative on CLLArticle Published on 2022-08-262022-11-15 Journal: Journal of Hematology & Oncology [Category] SARS, 진단, [키워드] 95%CI Admission advanced age affected age albumin Analysis anticoagulation therapy bleeding C-reactive protein CLL Complication conducted COVID-19 COVID-19 diagnosis D-dimer Data collection death deficiency defined development dose administration ENhance European event high risk Hospitalization Hospitalized ICU immune increased risk initiative leukemia LMWH Most patient multivariate model nasal Occurrence outcomes oxygen oxygen supplementation Patient peak D-dimer pharyngeal polymerase chain presence of comorbidities Prognostic factor prophylactic dose Protective receiving recommendation reported Retrospective multicenter study risk RT-PCR SARS-CoV-2 severe COVID-19 severity STROBE susceptible swabs the disease Thromboembolic event Thromboprophylaxis thrombosis Thrombotic events Treatment treatment for COVID-19 were used [DOI] 10.1186/s13045-022-01333-0 PMC 바로가기