Chronic SIV-Induced neuroinflammation disrupts CCR7 + CD4 + T cell immunosurveillance in the rhesus macaque brainResearch Article Published on 2024-03-122024-09-05 Journal: The World Allergy Organization Journal [Category] update2024, [키워드] Adaptive immunity AIDS/HIV Inflammation Neurological disorders T cells [DOI] 10.1172/JCI175332 PMC 바로가기 [Article Type] Research Article
Effect of host factors and COVID-19 infection on the humoral immune repertoire in treated HIVResearch Article Published on 2023-03-082024-09-05 Journal: JCI Insight [Category] update2024, [키워드] Adaptive immunity AIDS/HIV COVID-19 immunoglobulins obesity [DOI] 10.1172/jci.insight.166848 PMC 바로가기 [Article Type] Research Article
Durability of ChAdOx1 nCoV-19 vaccination in people living with HIVClinical Trial Published on 2022-04-082022-10-04 Journal: JCI Insight [Category] COVID19(2023년), SARS, 변종, 임상, 치료기술, [키워드] ACE-2 Adaptive immunity AIDS/HIV Antiretroviral therapy AZD1222 baseline Beta coronaviruses CD4 Cell-mediated immunity Cellular immune response ChAdOx1 nCoV-19 Cohort correlated COVID-19 cross-reactive detectable dose Duration Evidence greater HIV HIV-uninfected humoral IFN-γ ELISPOT IgG ELISA immune response Immunity individual majority male participant marker Meso Scale Discovery neutralization no significant difference prevaccination regimen response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike serology Support T cell T cell proliferation T cell response T cells Trial undetectable vaccinate vaccination variants of concern viral loads with HIV [DOI] 10.1172/jci.insight.157031 PMC 바로가기 [Article Type] Clinical Trial
HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cellsResource and Technical Advance Published on 2021-08-232022-10-30 Journal: JCI Insight [Category] COVID-19, SARS, [키워드] ACE2 ACE2 expression AIDS/HIV analyzed antiviral genes antiviral response canonical cause change chronic controls COVID-19 disease severity downregulation Enterocyte epithelial cell expression fatality GI Tract Gut highest HIV infection homeostasis impair increased risk individual individuals infect Innate immunity interferon response interferon signaling intestinal lymphoid mucosal Prevent Protein reduction SARS-CoV-2 SARS-CoV-2 entry receptor SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 receptor single-cell small intestine Symptoms target cell target cells tissue TMPRSS2 TMPRSS4 transcriptional profile treated uninfected upregulation vaccine response [DOI] 10.1172/jci.insight.148920 PMC 바로가기 [Article Type] Resource and Technical Advance
Relationship of SARS-CoV-2–specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis coinfectionSARS-COV-2- 특이 적 CD4 반응의 관계 COVID-19 중증도 및 HIV-1 및 결핵 공동 감염의 영향Clinical Trial Published on 2021-06-152022-08-13 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 임상, 진단, [키워드] AIDS/HIV Antigen attributes CD4 Cellular immune response characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 patient COVID-19 patients COVID-19 severity decrease Disease progression disease severity expression flow cytometry Frequency function HIV-1 HLA-DR hospitalized COVID-19 patients humoral immune response humoral immune responses immune responses implication involved knowledge magnitude Mycobacterium tuberculosis Patient patients phenotype proliferation reduced relationship SARS Coronavirus SARS-CoV-2 severe disease skewed Support T cell T cell depletion T cell response T cells the SARS-CoV-2 Tuberculosis [DOI] 10.1172/JCI149125 PMC 바로가기 [Article Type] Clinical Trial
Live attenuated varicella-zoster virus vaccine does not induce HIV target cell activationRandomized Controlled Trial Published on 2019-02-012023-06-01 Journal: The Journal of Clinical Investigation [Category] Fulltext, 두창, 수두, 홍역, [키워드] AIDS vaccine AIDS/HIV Cytokines T cells Vaccines [DOI] 10.1172/JCI124473 PMC 바로가기 [Article Type] Randomized Controlled Trial
How a new funding model will shift allocations from the Global Fund to Fight AIDS, tuberculosis, and malariaarticle Published on 2014-12-312024-09-01 Journal: Health affairs (Project Hope) [Category] 말라리아, [키워드] AIDS/HIV Financing Health Care health economics Health Spending International/global health studies [Article Type] article