Activation of AIM2 by hepatitis B virus results in antiviral immunity that suppresses hepatitis C virus during coinfectionarticle Published on 2023-10-032024-09-05 Journal: Journal of virology [Category] update2024, [키워드] AIM2 Hepatitis B virus hepatitis C virus Monocytes NK cells [DOI] 10.1128/jvi.01090-23 PMC 바로가기 [Article Type] article
An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2Article Published on 2023-02-082023-07-11 Journal: Cell Host & Microbe [Category] COVID19(2023년), [키워드] AIM2 IL-1β IL-6 Inflammasome NLRP1 NLRP3 SARS-CoV-2 STING TLR2 [DOI] 10.1016/j.chom.2022.12.005 PMC 바로가기
Identification of immunomodulatory drugs that inhibit multiple inflammasomes and impair SARS-CoV-2 infectionArticle Published on 2022-09-162022-11-16 Journal: Science Advances [Category] SARS, 신약개발, [키워드] acute respiratory syndrome AIM2 Asymptomatic COVID-19 autophagy coronavirus COVID-19 develop disease FDA-approved drug human monocyte identification immunomodulatory drug immunomodulatory function impair implicated in vitro in vivo independent induce Inflammasome inflammasome activation inflammasomes inflammatory process information inhibit inhibited inhibitors Mild NIC NLRP3 NLRP3 inflammasome Patient patients with COVID-19 PBMC performed provide SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication treat Treatment [DOI] 10.1126/sciadv.abo5400 PMC 바로가기
FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation Research Published on 2022-04-062022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 바이오마커, 변종, 신약개발, 치료기술, 치료법, 치료제, [키워드] abort activate activated Activation acute respiratory distress AIM2 Autopsy blood monocyte caspase-1 cause Cell contribute COVID-19 pathogenesis Culture death endothelial cells epithelial gasdermin D infected cell infected with SARS-CoV-2 Infection Infectious virus Inflammasome inflammasomes Inflammation Inflammatory Inflammatory cell death invasive lung Macrophage monocyte Monocytes NLRP3 patients with COVID-19 plasma promote pyroptosis receptors recipient replicate SARS-CoV-2 SARS-COV-2 infection severe COVID-19 supernatant systemic inflammation tissue-resident macrophages Trigger undergo Vaccine virus [DOI] 10.1038/s41586-022-04702-4 [Article Type] Research
STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS)STING 효능제 diABZI, PANoptosis 및 DNA 매개 급성 호흡 곤란 증후군(ARDS) 유도Article Published on 2022-03-252022-09-11 Journal: Cell Death & Disease [Category] SARS, 치료법, [키워드] Activation acute lung inflammation acute respiratory distress AIM2 airway amplification amplifying Apoptosis apoptosis induction ARDS CASP8 caspase-3 cell death cGAS cleavage complex contribute Cytokines cytoplasm DDX41 dinucleotide Disruption DNA DNase I double-stranded dsDNA ENhance epithelial extracellular DNA followed by gasdermin D IFN IFN-I IFNAR1 IL-1β IL-6 immune response immune responses induce Infection inflammasomes Inflammation Inflammatory Inflammatory cytokine Inflammatory cytokines Inflammatory response interferon IRF3 low dose lung Lung inflammation mice MLKL necroptosis NET NETosis neutrophilic neutrophilic response NF-kB NF-kB pathway NLRP3 NLRP3 inflammasome nucleotide pathway Phosphorylation priming pro-inflammatory cytokine pro-inflammatory cytokines pyroptosis receptor RIPK3 SARS-COV-2 infection severe ARDS signaling pathway silica smoke stimulator STING subsequent suggested syndrome TBK1 therapeutic strategy TLR9 TNFR1 TNFα Treatment triggered Tumor tumors Type I IFN type I IFN response type I interferon upregulation viral infection ZBP1 [DOI] 10.1038/s41419-022-04664-5 PMC 바로가기 [Article Type] Article
Epigenome-wide association study of COVID-19 severity with respiratory failureResearch article Published on 2021-04-162022-10-05 Journal: EBioMedicine [Category] 바이오마커, 유전자 메커니즘, [키워드] acute respiratory syndrome age age and sex AIM2 analysed association Biomarkers Candidates cellular Clinical course Clinical severity coding genes cohorts Comorbidities coronavirus coronavirus disease COVID-19 COVID-19 in patient COVID-19 patient COVID-19 patients COVID-19 severity CpG disease DNA methylation Epigenetic epigenetics Factors finding foundation funding Genes Genetic histocompatibility HLA-C Hospitalization identify immune system implicated individuals Inflammasome interferon involved loci Major management Mild Patient patients performed Peripheral blood sample regulated Regulation required Respiratory failure Respiratory Support responsible SARS-CoV-2 severity Stratification susceptibility loci the disease the SARS-CoV-2 viral infection [DOI] 10.1016/j.ebiom.2021.103339 [Article Type] Research article
Key Components of Inflammasome and Pyroptosis Pathways Are Deficient in Canines and Felines, Possibly Affecting Their Response to SARS-CoV-2 InfectionInflammasome 및 Pyroptosis 경로의 주요 구성 요소는 송곳니와 고양이에서 결핍되어 SARS-CoV-2 감염에 대한 반응에 영향을 미칠 수 있습니다Immunology Published on 2021-01-282022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 치료기술, [키워드] Activation activation of inflammasome AIM2 canine canines cats cause Comparative genomics component COVID-19 pandemic cytokine Cytokine storm deficiencies deficiency Deficient dog Excessive activation felines genomics study GSDMB GSDME Host infected with SARS-CoV-2 Infection Inflammasome mechanism Mild Mild symptom mild symptoms natural NLRC4 NLRP1 pathway performed pyroptosis reducing response SARS-CoV-2 SARS-COV-2 infection Severe Acute Respiratory Syndrome Corona Virus 2 Symptom Trigger [DOI] 10.3389/fimmu.2020.592622 PMC 바로가기 [Article Type] Immunology
Structure, Activation and Regulation of NLRP3 and AIM2 InflammasomesReview Published on 2021-01-162022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] Activation activation of inflammasome AIM2 ASC (apoptosis-associated speck-like protein containing a CARD), NLRP3 Cancer cardiometabolic disorders caspase-1 Cell cell death complex components danger signal Diseases downstream immune responses Infection Inflammasome inflammasome activation Inflammation initiate Interaction maintain maturation mechanism neurodegeneration NLRP3 NMR pathogenic platform Proinflammatory cytokine promote protein assembly protein structure recent Regulation required Signaling Structure [DOI] 10.3390/ijms22020872 PMC 바로가기 [Article Type] Review
The Emerging Relevance of AIM2 in Liver DiseaseReview Published on 2020-09-072023-06-03 Journal: International Journal of Molecular Sciences [Category] B형 간염, [키워드] Absent in melanoma 2 AIM2 cirrhosis fibrosis HCC Hepatitis Inflammasome Liver disease NAFLD NASH [DOI] 10.3390/ijms21186535 PMC 바로가기 [Article Type] Review
Triggers of NLRC4 and AIM2 inflammasomes induce porcine IL-1β secretionarticle Published on 2018-12-312024-09-01 Journal: Veterinary Research Communications [Category] 살모넬라증, [키워드] AIM2 Interleukin-1beta macrophages NLRC4 pig [Article Type] article