Vitamin D promotes epithelial tissue repair and host defense responses against influenza H1N1 virus and Staphylococcus aureus infectionsResearch Published on 2023-07-052024-09-05 Journal: Respiratory Research [Category] update2024, [키워드] Airway epithelial remodeling airway epithelium Airway organoids host responses Vitamin D [DOI] 10.1186/s12931-023-02477-4 PMC 바로가기 [Article Type] Research
Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airwaysArticle Published on 2022-10-282022-11-16 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 airway airway epithelium airways association C15orf48 cell population changes in characterized club co-expressed cohorts CTSL diagnostic workup disease severity elevated epithelial cells expressed expressing expression expression data Gene Expression gene expression pattern Goblet cell increase in indicated individual Infection lung cancer lung cancer risk modulate modulated nasal Population SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection scRNA-seq secretory cell severe disease significantly similarity smoker smoking smoking status subpopulation TMPRSS2 viral entry Viral load [DOI] 10.1038/s41598-022-17832-6 PMC 바로가기
The interplay between the airway epithelium and tissue macrophages during the SARS-CoV-2 infectionArticle Published on 2022-10-062022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] 3D cultures activate added Air-liquid interface air-liquid interface (ALI) airway airway epithelium Antigen presentation antiviral immune response basolateral side cell type co-culture Contact Course Culture cytokine production cytokine release demonstrated driven by epithelial epithelial cells evaluate HAE hMDM hMDMs Human airway epithelium human airway epithelium (HAE) human monocyte-derived macrophage immune response in viral infected cell Infection Innate immunity lung Macrophage macrophages phagocyte primary human airway recruitment Replication SARS-CoV-2 SARS-COV-2 infection Spread the SARS-CoV-2 tissue macrophage transfer virus virus replication [DOI] 10.3389/fimmu.2022.991991 PMC 바로가기
Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in Chronic Obstructive Pulmonary DiseaseArticle Published on 2022-08-312023-07-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), [키워드] Air-liquid interface airway epithelium cell sloughing ciliated cells COPD COVID-19 goblet cell hyperplasia goblet cells MUC5AC MUC5B SARS-CoV-2 syncytium [DOI] 10.1128/spectrum.00459-22 PMC 바로가기
Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway EpitheliumArticle Published on 2022-08-302023-06-14 Journal: mBio [Category] Fulltext, 신종인플루엔자, [키워드] airway epithelium Influenza virus interferon Macrophage mucin [DOI] 10.1128/mbio.01055-22 PMC 바로가기
Human genetic factors associated with pneumonia risk, a cue for COVID-19 susceptibility폐렴 위험과 관련된 인간 유전적 요인, COVID-19 감수성의 신호Meta-Analysis Published on 2022-08-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] Coronavirus, 변종, 유전자 메커니즘, [키워드] acquisition age airway epithelium Alter Analysis applied article association calculated case-control studies cause Community community acquired community acquired pneumonia contribute coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 susceptibility CYP1A1 driven by effect size Egger eligible evaluated expressed Factor funnel plot Genetic genetic etiology Genetic variant genetic variants healthy controls heterogeneity host genetics Human identify key factor likelihood Lung inflammation marker Maximum likelihood meta-analysed Meta-analysis Mortality nosocomial Nosocomial pneumonia Odds ratio Pathogenesis Patient performed Pneumonia Prevalence publication bias respiratory tract infection risk risk allele statistical significance subgroup analysis susceptibility Variability variant variants Viral pneumonia was performed were used [DOI] 10.1016/j.meegid.2022.105299 PMC 바로가기 [Article Type] Meta-Analysis
Immunofluorescence-Mediated Detection of Respiratory Virus Infections in Human Airway Epithelial CulturesArticle Published on 2022-06-012022-11-15 Journal: Current protocols [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome Air-liquid interface airway airway epithelial cell airway epithelium Analysis antibody basic Cell Cell culture cell tropism cellular coronavirus Culture current death detection determine double-stranded RNA Effect Efficiency epithelial Factor feature Generation Host Human human airway epithelial immortalized cell line immunofluorescence immunofluorescence microscopy in vivo include infect infected cell infected individual Infection Influenza virus LLC Microscopy Mild mucosal epithelium pathogen Periodical phenotype protocol respiratory respiratory tract respiratory virus rhinovirus Spread Symptom target upper respiratory tract viral pathogen virus [DOI] 10.1002/cpz1.453 PMC 바로가기
Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitroArticle Published on 2022-05-192022-10-04 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] Air-liquid interface airway epithelium Antiviral Antiviral effect Antiviral treatment BSA can be used cellular Combination complementary coronavirus coronavirus strain CRISPR-Cas systems cultures dependent on Endemic ENhance human coronaviruses human primary cells in vitro Infection inhibit magnitude mutations new SARS-CoV-2 offer omicron Prophylaxis reduced reduction RNA SARS-CoV-2 SARS-CoV-2 variant significantly small molecule drug Synthetic biology therapeutic effect treat Treatment vaccination variant variants viral evolution Viral RNA viral titer [DOI] 10.1038/s41467-022-30546-7 PMC 바로가기 [Article Type] Article
Airway epithelial interferon response to SARS-CoV-2 is inferior to rhinovirus and heterologous rhinovirus infection suppresses SARS-CoV-2 replicationSARS-CoV-2에 대한 기도 상피 인터페론 반응은 리노바이러스보다 열등하고 이종 라이노바이러스 감염은 SARS-CoV-2 복제를 억제합니다Article Published on 2022-04-282022-09-11 Journal: Scientific Reports [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료제, [키워드] addition AEC airway airway epithelial cell airway epithelial cells airway epithelium alphacoronavirus Betacoronavirus biosafety level Biosafety Level 3 bronchial BSL-3 cell lysate cell lysates children common Concentration correlated Culture cultures CXCL10 Delta delta variant Donor elicit epithelial epithelial cells evade Ex vivo experiment Gene Expression generate greater heterogeneity Heterologous highly pathogenic HRV IFN IFN response IFN-β IFN-λ IFNB1 induce Infection interferon interferon response less level 3 Older omicron Protein recombinant IFN recombinant IFN-β reduce reduced replicated response responses rhinovirus RNA robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication significantly subset supernatant suppresse Treatment type I variant variants viral replication was collected were infected [DOI] 10.1038/s41598-022-10763-2 PMC 바로가기 [Article Type] Article
The Type 2 Asthma Mediator IL-13 Inhibits Severe Acute Respiratory Syndrome Coronavirus 2 Infection of Bronchial EpitheliumArticle Published on 2022-04-012023-07-07 Journal: American Journal of Respiratory Cell and Molecular [Category] COVID19(2023년), [키워드] airway epithelium Asthma COVID-19 IL-13 SARS-CoV-2 [DOI] 10.1165/rcmb.2021-0364OC PMC 바로가기