Type D lymphomatoid papulosis with pityriasis lichenoides et varioliformis acuta-like features in a child with parvovirus infection: a controversial diagnosis in the spectrum of lymphoid proliferations: case report and literature reviewArticle Published on 2022-10-282022-11-16 Journal: Italian Journal of Pediatrics [Category] COVID19(2023년), SARS, 치료기술, [키워드] Administered Alanine antigenic Aspartate aminotransferase Bilirubin C-reactive protein Case report CD8+/CD30+ cells children clinical response clinical suspicion Critical cytokine profile Cytokines Department Diagnosis differential diagnosis discharged disease disorder Emergency erythematous feature Fever histological history Hospitalized IFN-γ IL-10 IL-6 immunoglobulin M infectious agent infiltration introduced Laboratory test lesion lesions limits literature review lymphoid lymphomatoid Lymphomatoid papulosis lymphoproliferative Lymphoproliferative cutaneous disorders marker mechanism monoclonal morphologically necrotic Parvovirus parvovirus B19 pathogenic Perspective phenotype pityriasis lichenoides et varioliformis acuta. polymerase chain reaction positive response proliferation Rash recorded regions reported representing returned SARS-CoV-2 antigen separated skin lesions steroid Support Symptom systemic corticosteroid T-cell receptor Therapies Treatment Type Type D [DOI] 10.1186/s13052-022-01371-x PMC 바로가기
A systematic exploration of boceprevir-based main protease inhibitors as SARS-CoV-2 antiviralsSARS-CoV-2 항바이러스제로서의 보세프레비르 기반 주요 프로테아제 억제제의 체계적인 탐색Article Published on 2022-10-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 293T cell 293T cells active site Alanine aldehyde amide Antiviral antiviral potency boceprevir Carbamate carbamide changed characterized complex covalent inhibitor COVID-19 crystal structure crystal structures cysteine cytotoxicity expressed HCV hydrophobic hydrophobic interaction IMPROVE in vitro inhibit inhibitor inhibitors isovaleramide M pro main protease Modification modifications N-terminal nitrile observation Opal PF-07321332 Pro protease Protease inhibitor recognize residue reversed SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 variants side chain substrate tested the SARS-CoV-2 undetectable unique warhead [DOI] 10.1016/j.ejmech.2022.114596 PMC 바로가기 [Article Type] Article
Pharmacogenetic variants and risk of remdesivir-associated liver enzyme elevations in Million Veteran Program participants hospitalized with COVID-19COVID-19로 입원한 백만 재향 군인 프로그램 참가자의 약물 유전적 변이 및 렘데시비르 관련 간 효소 상승 위험Article Published on 2022-08-012022-09-11 Journal: Clinical and translational science [Category] COVID19(2023년), SARS, 변종, [키워드] adjusted administration age Alanine alanine aminotransferase ALT assigned association baseline black Comorbidities components conducted coronavirus disease Coronavirus disease 2019 COVID-19 CYP2C19 drug Drug administration Elevation enzyme food Hospitalized Linear regression liver enzyme liver enzymes log-transformed Million Veteran Program multifactorial multivariable model participant Participants Patient pharmacogenetic phenotype receiving Remdesivir retrospective risk Sex stratified Treatment treatment initiation variant was performed white with COVID-19 [DOI] 10.1111/cts.13313 PMC 바로가기 [Article Type] Article
Evaluation of Remdesivir for Mildly to Moderately Ill Patients with COVID-19: A Single-Arm, Single-Center, Retrospective Study경증에서 중등도의 COVID-19 환자를 위한 렘데시비르 평가: 단일 암, 단일 센터, 후향적 연구Article Published on 2022-07-272022-09-11 Journal: Medicina [Category] COVID19(2023년), SARS, 치료기술, [키워드] 6-point ordinal scale Adverse adverse events Alanine alanine aminotransferase Antiviral antiviral agent approved Clinical improvement clinical status Common Terminology Criteria coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient CTCAE death discharge effective Efficacy and safety elevated enrolled event grade 3 hospital Ill ill patient initiated Japan Japanese material neutropenia objective one patient Ordinal Scale oxygen Oxygen therapy Patient patients patients with COVID-19 primary end point profiles RDV receiving Remdesivir required Result Retrospective study single-center study period Treatment university was performed were assessed with COVID-19 [DOI] 10.3390/medicina58081007 PMC 바로가기 [Article Type] Article
[Clinical features of children with coronavirus disease 2019 Delta variant infection after vaccination with inactivated SARS-CoV-2 vaccine][SARS-CoV-2 비활성화 백신 접종 후 코로나바이러스 질환 2019 델타 변이체 감염 아동의 임상적 특징]Article Published on 2022-07-152022-09-11 Journal: Zhongguo dang dai er ke za zhi = Chinese journal o [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Admission Alanine alanine aminotransferase aspartate Aspartate aminotransferase B lymphocyte B lymphocytes C-reactive protein caused CD3 Child children children with COVID-19 China Chinese clinical clinical feature Clinical features clinical symptom Clinical symptoms coronavirus coronavirus disease Coronavirus disease 2019 cough Course COVID-19 creatine creatine kinase Creatine kinase-MB creatinine Ct value cytokine Cytokines Delta delta variant disease disease classification elevated English enrolled epidemiological data expectoration feature Fever Gender hospital Hospitalized IgG immune function inactivated incidence rate incidence rates Infection Laboratory laboratory examination Lactate lactate dehydrogenase leukocyte lymphocyte myocardial injury no significant difference nucleic acid Peripheral blood positive rate procalcitonin proportion reduce Retrospective analysis SARS-CoV-2 SARS-CoV-2 vaccine serum creatinine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant difference significantly higher significantly lower T lymphocyte two group two groups vaccination Vaccine was performed [DOI] 10.7499/j.issn.1008-8830.2203174 PMC 바로가기 [Article Type] Article
COVID-19 vaccination elicits an evolving, cross-reactive antibody response to epitopes conserved with endemic coronavirus spike proteinsCOVID-19 백신 접종은 고유의 코로나바이러스 스파이크 단백질로 보존된 에피토프에 대한 진화하는 교차 반응성 항체 반응을 이끌어냅니다Article Published on 2022-07-052022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] Alanine antibody conserved coronavirus coronavirus spike protein CoV COVID-19 pandemic COVID-19 vaccination CoVs CP: Immunology CP: Microbiology cross-reactive cross-reactive antibody detectable elicit Endemic epitope Epitopes experiments homolog identify Immunity immunology longitudinal samples mechanism Microbiology mRNA mRNA-1273 mRNA-1273 vaccine multiplexed serology observé other coronavirus other coronaviruses phylogenetically reactivity regions residue SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes serology spike subject the vaccine trajectory triggered vaccination vaccine response vaccine-induced antibody response widespread [DOI] 10.1016/j.celrep.2022.111022 PMC 바로가기 [Article Type] Article
Safety and Immunogenicity of SARS-CoV-2 Vaccines in Patients With Chronic Liver Diseases (CHESS-NMCID 2101): A Multicenter Study만성 간 질환 환자에서 SARS-CoV-2 백신의 안전성 및 면역원성(CHESS-NMCID 2101): 다기관 연구Multicenter Study Published on 2022-07-012022-09-12 Journal: Clinical gastroenterology and hepatology : the off [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome adverse event Adverse reaction Alanine All participant China chronic chronic liver disease Chronic Liver Diseases cirrhosis CLD collected compensated coronavirus defined dose enrolled healthy healthy control healthy volunteer healthy volunteers immunogenicity immunologic response inactivated injection site pain Laboratory testing limit Mild MOST multicenter study Open-label participant Patient positive rate reported Safe Safety SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines second dose serum sample subgroups subject tested Vaccine were recorded whole-virion SARS-CoV-2 vaccine [DOI] 10.1016/j.cgh.2021.12.022 PMC 바로가기 [Article Type] Multicenter Study
Serum homocysteine level in pediatric patients with COVID-19 and its correlation with the disease severity소아 코로나19 환자의 혈청 호모시스테인 수치와 질병 중증도와의 상관관계Article Published on 2022-07-012022-09-11 Journal: Pediatric pulmonology [Category] MERS, 바이오마커, [키워드] acute infection Admission adult COVID-19 patients Adults Alanine Alanine transaminase aspartate Aspartate transaminase Biomarker Biomarkers Blood urea nitrogen children children with COVID-19 Complication conducted Control coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 COVID-19 patient cross-sectional cross-sectional study D-dimer detect disease severity Embolism enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay ferritin fibrinogen fibrinogen degradation product fibrinogen degradation products healthy control homocysteine homocysteine. increase in intensive care interquartile range Laboratory median nitrogen parameter patients pediatric Pediatric patient Pediatric patients pediatrics positive correlation prothrombin Prothrombin time prothrombotic radiological Radiological parameters reported risk serum severity severity of COVID-19 speculation statistically significant subjects syndrome the disease thrombosis urea was measured with COVID-19 [DOI] 10.1002/ppul.25920 PMC 바로가기 [Article Type] Article
Exposing and Overcoming Limitations of Clinical Laboratory Tests in COVID-19 by Adding Immunological Parameters; A Retrospective Cohort Analysis and Pilot Study면역학적 매개변수를 추가하여 COVID-19에서 임상 실험실 테스트의 한계를 노출하고 극복합니다. 후향적 코호트 분석 및 파일럿 연구Article Published on 2022-06-292022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] acute phase acute phase reactants Adding adopted age Alanine alanine aminotransferase Algorithm Analysis aspartate Aspartate aminotransferase association Barcelona best Biomarker C-reactive protein category CCL2 chemokines classical clinical clinical and laboratory variables clinical laboratories clinical laboratory clinical laboratory tests Clinical management clinical parameter Clinical parameters clinical variable clinical variables Cohort collected Comorbidity conducted COVID 19 patient COVID 19 patients COVID-19 COVID-19 pandemic COVID-19 patient CXCL10 cytokine Cytokines exploratory feasible fibrinogen filtration rate First wave flow cytometry fraction glomerular filtration rate IL-1ra IL-6 immune response immunological Immunological test immunological tests IMPROVE independent Inflammation Interpretation Laboratory Laboratory test Laboratory tests limitation lymphocyte neutrophil organ organ damage outcome overcome oxygen oxygen saturation pandemic patients performed phenotype pilot study Predictive predictive power predictive risk-profile. predictor Prognosis redundancy reflected SARS-CoV-2 SARS-COV-2 infection severity statistical statistical analysis survival Test two subgroup two subgroups understanding validation cohort validation cohorts variable [DOI] 10.3389/fimmu.2022.902837 PMC 바로가기 [Article Type] Article
Cytokines and Lipid Mediators of Inflammation in Lungs of SARS-CoV-2 Infected MiceSARS-CoV-2에 감염된 마우스의 폐에서 염증의 사이토카인 및 지질 매개체Article Published on 2022-06-242022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alanine Analysis analyzed animal animal model animal models Blood blood clot Blood clots characterized chemokine chemokines circulating clinical manifestation Concentration coronavirus 2 coronavirus disease coronavirus disease 19 correlated COVID-19 Cytokines D-dimer D-dimers different time point different time points elevated ethanolamide event events Features Genes glycerol glycine hallmark highlight histology Human hydroxy indicated Infection Inflammation inflammatory mediator Inflammatory mediators interferons K18-ACE2 knowledge leukocyte leukocyte infiltration Lipid lipid mediator lipid mediators of inflammation lipids lung Lung inflammation lung tissue lung tissues lung viral load Lungs mass spectrometry Measures mediator mice modulation Other Pathogenesis pathology pathophysiological performed PGF plasma Post-infection produced prostaglandin reduced Replication RNA-seq analysis robust SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 severe COVID-19 significantly Support Tandem mass spectrometry therapeutic strategy transcriptomic transgenic mice treat uninfected vasculature viral replication [DOI] 10.3389/fimmu.2022.893792 PMC 바로가기 [Article Type] Article