US veterinarians’ perceptions of discussing COVID-19 vaccination with animal owners during routine visitsResearch article Published on 2022-12-012022-10-05 Journal: One Health [Category] 진단, [키워드] aligned approved Care catastrophic Community COVID-19 COVID-19 pandemic COVID-19 vaccination Disparities events finding Health individual information one health potential barrier Practitioner prevention public health shifting The United States unique vaccination Vaccine Vaccine hesitancy Vaccines Veterinarian [DOI] 10.1016/j.onehlt.2022.100418 [Article Type] Research article
Bioinformatics pipeline unveils genetic variability to synthetic vaccine design for Indian SARS-CoV-2 genomesArticle Published on 2022-11-012022-11-15 Journal: International immunopharmacology [Category] SARS, 치료기술, 치료제, [키워드] aligned amino acid change antigenic antigenic epitopes B-cell epitope bioinformatics bioinformatics pipeline can be used clade clades conserved conserved regions criteria epitope Evolution genetic variability genomic HLA allele identify immunogenic MAFFT MHC-I MHC-II Multiple sequence alignment Mutation Nextstrain Non-synonymous Non-Synonymous Signature SNP performed Phylogenetic analysis primer probe Protein Region regions reported resulting SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 pandemic selected SNP SNPs T-cell T-cell epitope T-cell epitopes unique Vaccine Vaccine design virus virus detection virus genome [DOI] 10.1016/j.intimp.2022.109224 PMC 바로가기
A comprehensive update on CIDO: the community-based coronavirus infectious disease ontologyArticle Published on 2022-10-212022-11-16 Journal: Journal of Biomedical Semantics [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] aligned Amino acid amino acid substitution Analysis applied basic Clinical data clinical trial coronavirus coronavirus disease COVID-19 COVID-19 pandemic Delta Diagnosis diagnostic disease domain drug Drug repurposing drug-target effective Epidemiology evaluated example Formal global public health heterogeneous Human Infectious disease initiated knowledge Metadata omicron ontologies Ontology outbreak phenotype PPI protein-protein interaction Safe SARS-CoV-2 SARS-CoV-2 protein Standardization Support supported target protein Treatment Vaccine variant variants variants of SARS-CoV-2 virus [DOI] 10.1186/s13326-022-00279-z PMC 바로가기
Reproducibility of real-world evidence studies using clinical practice data to inform regulatory and coverage decisions Research Published on 2022-08-312022-10-05 Journal: Nature Communications [Category] 임상, [키워드] aligned Analysis Clinical practice collected Completeness Coverage database Effect effect size effective Ensuring evaluate Evidence explained generate Guidance healthcare IMPROVE interquartile range investigator magnitude majority median methodological original peer-reviewed positively correlated Regulatory reproducibility subset Validity while [DOI] 10.1038/s41467-022-32310-3 [Article Type] Research
Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19COVID-19의 적응 면역 구획 전반에 걸친 항원 수용체 레퍼토리 파괴의 글로벌 패턴Article Published on 2022-08-232022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 치료기술, [키워드] adaptive adaptive immune responses aligned anticipated Antigen antigen-receptor repertoires applied approach B cell Cluster COVID-19 deficiency disease disease severity enrichment genomic Genomic DNA IGH immune immune responses Immunoglobulin immunoPETE individuals Infectious disease loci Next-generation sequencing occurred Older pathogen pathogen-specific Patient primary focus receptor reducing risk factor SARS-CoV-2 sequence Seroconversion T cell T cell receptor T cells TCR variant vulnerability [DOI] 10.1073/pnas.2201541119 PMC 바로가기 [Article Type] Article
Investigating Linkages Between Spatiotemporal Patterns of the COVID-19 Delta Variant and Public Health Interventions in Southeast Asia: Prospective Space-Time Scan Statistical Analysis MethodCOVID-19 델타 변이의 시공간 패턴과 동남아시아의 공중 보건 개입 간의 연관성 조사: 전향적 시공간 스캔 통계 분석 방법Article Published on 2022-08-092022-09-11 Journal: JMIR Public Health and Surveillance [Category] SARS, 변종, 치료기술, [키워드] adopted aligned Analysis analyzed Asia assistance benefit Cluster Clusters collected Continuous continuous surveillance country COVID-19 COVID-19 transmission cumulative Delta delta variant effective Effectiveness Epidemic exacerbate heterogeneity identify increase in Indonesia infection risk Intervention linkage Malaysia measure NPI outbreak pattern progression Propagation Prospective Public public health authorities public health authority Public health intervention reducing Relative risk risk risk of COVID-19 SEA shown Singapore Southeast Asia space-time scan. spatiotemporal Surveillance Transmission Variation variations [DOI] 10.2196/35840 PMC 바로가기 [Article Type] Article
Bioactive potentiality of secondary metabolites from endophytic bacteria against SARS-COV-2: An in-silico approachSARS-COV-2에 대한 내생 세균의 2차 대사 산물의 생리 활성 가능성: In-silico 접근Article Published on 2022-08-042022-09-11 Journal: PLoS ONE [Category] SARS, 치료기술, 치료제, [키워드] 3CLpro accelerate accession number aligned ammonia analyses Analysis analyzed antioxidant approach associations Bacillus Bacteria Bacterial biochemically chymotrypsin Chymotrypsin-like protease collected Compound computational tool coronavirus Culture docked docking scores drug-likeness effective enzyme flask culture flavonoid GenBank identify in silico analysis in-silico inhibitor Interaction isolate Lopinavir metabolite metabolites Micrococcus morphologically nine NMR nucleotide nucleotide sequence outcome performed phytohormone plant profiles protease protein-protein network protein-protein networks protocol Pseudomonas species rDNA reported Research Sanger sequencing Secondary Metabolite sequence similarity Staphylococcus structures submission target protein target proteins tested these compounds was performed were assessed [DOI] 10.1371/journal.pone.0269962 PMC 바로가기 [Article Type] Article
Phylogenetic analysis of human parainfluenza type 3 virus strains responsible for the outbreak during the COVID-19 pandemic in Seoul, South KoreaResearch article Published on 2022-08-012022-10-05 Journal: Journal of Clinical Virology [Category] 변종, [키워드] Acute respiratory infection aligned amino acid sequence analyses Analysis bootstrap C3a C3c cause Characteristics children circulating Cluster collected COVID-19 pandemic Emerging lineages Epidemic gene sequence Genetic Human Human Parainfluenza Virus 3 Infant Lineage molecular mutations nasopharyngeal swab specimen nucleotide sequence outbreak parainfluenza parainfluenza virus 3 Phylogenetic Phylogenetic analysis potential risk Protein ranged respiratory pathogen responsible Result South Korea specimens strain Substitution Support unique virus strain [DOI] 10.1016/j.jcv.2022.105213 [Article Type] Research article
Treatment with metformin glycinate reduces SARS-CoV-2 viral load: An in vitro model and randomized, double-blind, Phase IIb clinical trial메트포르민 글리시네이트로 치료하면 SARS-CoV-2 바이러스 부하 감소: 시험관 내 모델 및 무작위, 이중 맹검, IIb상 임상 시험Randomized Controlled Trial Published on 2022-08-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] adaptive aligned Alpha caused Cell Clinical data clinical trial conducted control group coronavirus disease COVID-19 COVID-19 patients COVID-19 treatment dose doses double-blind drug effort Epsilon evaluate exposure to Health Health crisis highlight highlighting identify IIb in vitro in vitro model in vitro result in vitro study in vivo increased survival indicate inhibit metformin Metformin glycinate New coronavirus new coronavirus SARS-CoV-2 new treatment strategy new virus oxygen phase Randomized reduce reduced SARS-CoV-2 SARS-CoV-2 variants SARS-CoV-2 viral SARS-CoV-2 viral load severe disease supplementary oxygen tested the SARS-CoV-2 therapeutic option treated Treatment Treatment effectiveness triggered variant variants of interest Vero E6 VERO E6 cells viral infection Viral load viral replication [DOI] 10.1016/j.biopha.2022.113223 PMC 바로가기 [Article Type] Randomized Controlled Trial
Cardiovascular subphenotypes in patients with COVID-19 pneumonitis whose lungs are mechanically ventilated: a single-centre retrospective observational studyObservational Study Published on 2022-07-012022-10-04 Journal: Anaesthesia [Category] 임상, [키워드] acute respiratory distress acute respiratory distress syndrome age aligned Analysis cardiovascular Clinical characteristics clinical outcomes cohort study conducted echocardiographic ICU patient impairment IQR Latent latent class lung male mechanically ventilated mechanism median moderate mortality rate mortality rates outcomes parameters pathophysiology Patient patients with COVID-19 performed preserved Prone ventilation retrospective right ventricular dysfunction right ventricular failure syndrome transthoracic echocardiography Treatment response Unsupervised clustering variable variables ventricular ventricular dysfunction with COVID-19 [DOI] 10.1111/anae.15700 PMC 바로가기 [Article Type] Observational Study