Identifying plant-derived antiviral alkaloids as dual inhibitors of SARS-CoV-2 main protease and spike glycoprotein through computational screeningPharmacology Original Research Published on 2024-07-172024-09-05 Journal: Frontiers in Pharmacology [Category] update2024, [키워드] alkaloids main protease SARS-CoV-2 secondary metabolites spike glycoprotein [DOI] 10.3389/fphar.2024.1369659 PMC 바로가기 [Article Type] Pharmacology Original Research
In silico identification of deep-sea fungal alkaloids as potential inhibitors of SARS-CoV-2, Delta and Omicron spikesarticle Published on 2023-10-262024-09-05 Journal: Future Virology [Category] update2024, [키워드] alkaloids deep-sea fungi Delta molecular docking omicron SARS-CoV-2 Spike protein [DOI] 10.2217/fvl-2023-0102 PMC 바로가기 [Article Type] article
Korupensamine A, but not its atropisomer, korupensamine B, inhibits SARS-CoV-2 in vitro by targeting its main protease (M pro )Research Paper Published on 2023-02-282024-09-05 Journal: European journal of medicinal chemistry [Category] update2024, [키워드] alkaloids MPro Naphthylisoquinolines natural products SARS-CoV-2 Steered molecular dynamics [DOI] 10.1016/j.ejmech.2023.115226 PMC 바로가기 [Article Type] Research Paper
Curative Potential of High-Value Phytochemicals on COVID-19 InfectionReview Published on 2023-02-172024-09-05 Journal: Biochemistry. Biokhimiia [Category] update2024, [키워드] alkaloids COVID-19 high-value phytochemicals medicinal plants natural products Phenolics terpenoids [DOI] 10.1134/S0006297923010066 PMC 바로가기 [Article Type] Review
Antimalarial Natural ProductsArticle Published on 2022-12-312024-09-10 Journal: Prog Chem Org Nat Prod [Category] 말라리아, [키워드] alkaloids Artemisinin malaria mechanism of action natural products Plasmodium falciparum Quinine Terpenoids. PMC 바로가기
In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspectiveArticle Published on 2022-08-222022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 신약개발, [키워드] absence acute respiratory syndrome alkaloids analyzed anti-SARS-CoV-2 approach approved assist binding binding energy caused Clinicians Compound computer-aided drug design contribute coronavirus COVID-19 death derivative determine Diseases drug candidate drug design Drug discovery drugs effective facilitate highest in silico Ligand mechanism Medicines natural natural products Perspective pharmacological physician phytochemical Practitioner public health RdRP reported Research researcher researchers RNA polymerase Safe SARS-CoV-2 SARS-CoV-2 main protease subsequent therapeutic Therapeutic approach therapeutic molecules therapeutic target took place Toxicity Treatment vaccination viral replication Virtual screening [DOI] 10.3389/fcimb.2022.929430 PMC 바로가기
Modern drug discovery applications for the identification of novel candidates for COVID-19 infectionsReview article Published on 2022-08-012022-10-05 Journal: Annals of Medicine and Surgery [Category] 변종, 신약개발, 유전자 메커니즘, 치료기술, 치료제, [키워드] alkaloids Analysis candidate Characteristics Compound computational contagious coronavirus cough COVID-19 COVID-19 infection diagnosed Drug discovery effective Epidemic Evolution Fever Glycosides Illness severity in silico Infection investigated minor symptom molecular docking Numerous occurred outbreak plasma Pneumonia predicted reduce required researcher RNA RT-PCR shown Spread Symptoms terpenoids the disease therapeutic therapy Transmission Travel Treatment vaccination virus World Health Organization Wuhan, China [DOI] 10.1016/j.amsu.2022.104125 [Article Type] Review article
The naturally-derived alkaloids as a potential treatment for COVID-19: A scoping reviewCOVID-19의 잠재적 치료제로서의 천연 유래 알칼로이드: 범위 검토Review Published on 2022-07-012022-09-11 Journal: Phytotherapy research : PTR [Category] COVID19(2023년), SARS, 치료제, [키워드] activities acute respiratory syndrome coronavirus alkaloids Anti-inflammatory Antiviral applicability assessments berberine binding energy caused cephaeline clinical trial clinical trials Colchicine coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 database described Effects eligible Emetine Ergotamine high mortality rate homoharringtonine in silico in vitro Inflammatory marker inflammatory markers inhibit knowledge lycorine medicinal plant narciclasine natural product new treatment strategy observational studies papaverine pharmacological plant Potential treatment Protein target protein targets Quinine reduce respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 target proteins Therapeutic compounds Transmissibility treating COVID-19 variety was performed [DOI] 10.1002/ptr.7442 PMC 바로가기 [Article Type] Review
In-silico screening of naturally derived phytochemicals against SARS-CoV Main proteaseSARS-CoV Main protease에 대한 천연 유래 식물화학물질의 in-silico 스크리닝Article Published on 2022-04-012022-09-11 Journal: Environmental science and pollution research inter [Category] 치료제, [키워드] against SARS-CoV alkaloids analogues anti-SARS-CoV-2 therapeutics approved binding score candidate Clinical studies coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment guideline COVID-19 treatment guidelines drug effective Effects Environment FDA-approved drug FDA-approved drugs finding Glucosinolates in vitro lead library MPro pandemic pharmacological Phytomedicines Phytoremedies platform Previous studies protease Protease inhibitor Safe therapeutic effect therapeutic intervention Treatment treatment of COVID-19 Vaccine Virtual screening [DOI] 10.1007/s11356-021-17642-9 PMC 바로가기 [Article Type] Article
Isolation and Structural Elucidation of Compounds from Pleiocarpa bicarpellata and Their In Vitro Antiprotozoal ActivityArticle Published on 2022-03-282024-08-28 Journal: Molecules [Category] 말라리아, [키워드] alkaloids antiprotozoal activity dereplication malaria Pleiocarpa