Implementation of an Approach to Equitable Allocation of SARS-CoV-2 Monoclonal Antibodies for Preexposure Prophylaxis: Experience From a Single Medical Centerarticle Published on 2024-08-102024-09-05 Journal: Open Forum Infectious Diseases [Category] update2024, [키워드] allocation COVID-19 disparity preexposure prophylaxis SARS-CoV-2 monoclonal antibodies [DOI] 10.1093/ofid/ofae388 PMC 바로가기 [Article Type] article
A method for intelligent allocation of diagnostic testing by leveraging data from commercial wearable devices: a case study on COVID-19 Research Published on 2022-09-012022-10-05 Journal: NPJ Digital Medicine [Category] 바이오마커, 유전자 메커니즘, 진단, 치료기술, [키워드] aggregate allocation AUC Biomarker characteristic Course COVID-19 diagnostic emerging disease feature Features Fitbit generate help High-resolution IMPROVE increase in independent individual individuals Infection Infectious disease mass surveillance Metrics occur outbreak parameter Participants positive prevalent reduce resource Self-reported symptoms Surveillance surveillance testing symptomatic and asymptomatic tested Testing variant [DOI] 10.1038/s41746-022-00672-z [Article Type] Research
Too old to save? COVID-19 and age-based allocation of lifesaving medical careArticle Published on 2022-09-012023-07-09 Journal: Bioethics [Category] COVID19(2023년), [키워드] allocation COVID-19 Ethics Justice Older adults [DOI] 10.1111/bioe.13041 PMC 바로가기
Fair Allocation of Scarce Therapies for Coronavirus Disease 2019 (COVID-19)코로나바이러스 질병 2019(COVID-19)에 대한 희소한 치료제의 공정한 할당Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, [키워드] ad hoc allocation antiviral drug antiviral drugs antivirals approach asked bioethics category Clinical risk factors Community coronavirus disease Coronavirus disease 2019 COVID-19 delta variant disease doses drug Emergency use authorization EUA exclusion Factor Fair FDA food Government group Health health inequities healthcare identify Immunocompromise Inclusion individual mAbs Mild moderate molnupiravir monoclonal monoclonal antibodies monoclonal antibody Older age omicron Omicron variant Patient Paxlovid Postexposure Prophylaxis rationing required scarcity supply Therapies therapy US Food and Drug Administration vaccination variant [DOI] 10.1093/cid/ciab1039 PMC 바로가기 [Article Type] Article
Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysisCOVID-19로 병원에 입원한 환자의 바리시티닙(RECOVERY): 무작위, 통제, 공개 라벨, 플랫폼 시험 및 업데이트된 메타 분석Meta-Analysis Published on 2022-07-302022-09-11 Journal: Lancet (London, England) [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 28-day mortality 95% CI age-adjusted rate ratio allocation Baricitinib benefit by mouth cause Corticosteroid Corticosteroids COVID-19 COVID-19 therapy death deaths died discharge eight enrolled evaluate Evidence hospital hospitalised Including Infection inhibitor Innovation intention-to-treat population ISRCTN Jak JAK inhibitor jak inhibitors janus Janus kinase Medical Research Council Meta-analysis mouth nine Non-COVID-19 once daily Open-label outcomes Patient Platform trial Primary outcome Proportional reduction randomisation randomised randomised controlled trial Randomised Evaluation Randomly randomly assigned patient rate ratio receive receiving recorded recovery RECOVERY trial reduce mortality reduced reduction in mortality Registered risk of death significantly Standard of care suggested thrombosis Tocilizumab Treatment Trial trials usual care usual care alone usual care group was done with COVID-19 [DOI] 10.1016/S0140-6736(22)01109-6 PMC 바로가기 [Article Type] Meta-Analysis
COUNTERPOINT: Is Considering Social Determinants of Health Ethically Permissible for Fair Allocation of Critical Care Resources During the COVID-19 Pandemic? NoEditorial Published on 2022-07-062022-10-05 Journal: Chest [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] allocation COVID-19 determinant Fair [DOI] 10.1016/j.chest.2022.03.029 [Article Type] Editorial
Randomised controlled trial of a behaviour change physiotherapy intervention to increase physical activity following hip and knee replacement: the PEP-TALK trialRandomized Controlled Trial Published on 2022-05-312022-10-05 Journal: BMJ Open [Category] 임상, [키워드] 1:1 95% CI activity adult orthopaedics adverse event age allocation Blinding Care cognitive Comorbidities Compliance contributed Controlled trial COVID-19 pandemic Effectiveness eligibility English Evidence hip hospital hospitals inactive individual Intervention knee Los Angele National Health Service nine no difference outcome Pain participant physical activity Physical inactivity Pragmatic proportion Psychological distress Quality of life randomised randomised controlled receive reduced rehabilitation rheumatology Sample size score secondary outcome Self-efficacy Trial Two-arm University of California usual care women [DOI] 10.1136/bmjopen-2022-061373 PMC 바로가기 [Article Type] Randomized Controlled Trial
Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses코로나19 입원 환자를 위한 렘데시비르 및 기타 3가지 약물: WHO 연대 무작위 시험의 최종 결과 및 업데이트된 메타 분석Meta-Analysis Published on 2022-05-212022-09-11 Journal: Lancet (London, England) [Category] 신약개발, 임상, 치료제, [키워드] 1:1 allocation Analysis antiviral drugs assigned average both groups Characteristics Compliance controls country COVID-19 COVID-19 diagnosis database death died discharge discharged disease severity drug drugs eligible patient Endpoint enrolled exclusion Final futility hospital Hospital mortality hospitalised hospitalised patient Hospitalised patients Hydroxychloroquine in both groups in-hospital mortality Inpatient Inpatients interferon ISRCTN Kaplan-Meier Local Lopinavir meta-analyses Meta-analysis Mortality mortality analysis mortality rate ratio no significant effect occurred Open-label outcome oxygen participant Patient patients patients with COVID-19 Placebo placebos primary endpoint progressed progression proportion randomisation Randomised trial Randomly rate ratio receive recruited regions Registered Remdesivir reported secondary Secondary endpoints solidarity Solidarity trial Standard of care study drug the WHO treatment period Trial Ventilated Ventilation were given WHO [DOI] 10.1016/S0140-6736(22)00519-0 PMC 바로가기 [Article Type] Meta-Analysis
Development and evaluation of a machine learning-based in-hospital COVID-19 disease outcome predictor (CODOP): A multicontinental retrospective study기계 학습 기반 병원 내 COVID-19 질병 결과 예측기(CODOP) 개발 및 평가: 다대륙 후향적 연구Article Published on 2022-05-172022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] allocation AUROC breakthrough infections calibrated Clinical outcome clinical parameter clinical utility clinically Cohort cohort of patient Computational biology country COVID-19 COVID-19 disease COVID-19 patient deaths development disperse effective heterogeneous hospital Hospital admission hospital resources Hospitalization hospitalizations hospitalized COVID-19 patients Human In-hospital Latin Latin America machine-learning maintain Medicine New offer outcome pandemic patient cohort patient cohorts prediction Predictive Retrospective study risk stratification SARS-CoV-2 variants sensitivity Spain specificity Systems biology tested Triage USA vaccination vaccination rate Vaccination Status variant virus waning immunity [DOI] 10.7554/eLife.75985 PMC 바로가기 [Article Type] Article
Repair of acute respiratory distress syndrome by stromal cell administration (REALIST): a structured study protocol for an open-label dose-escalation phase 1 trial followed by a randomised, triple-blind, allocation concealed, placebo-controlled phase 2 trial간질 세포 투여에 의한 급성 호흡 곤란 증후군의 회복(REALIST): 공개 라벨 용량 증량 1상 시험에 이어 무작위, 삼중 맹검, 할당 은폐, 위약 대조 2상 시험을 위한 구조화된 연구 프로토콜Article Published on 2022-05-132022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 acute respiratory distress acute respiratory distress syndrome administration allocation ARDS benefit blind causes Cell cells clinical clinical trial Cohort cohort of patient cohorts of patients concealed CONSORT COVID-19 distress dose dose-escalation early stage early stages Efficacy EudraCT Good immunomodulatory incidence include Mesenchymal stem cells Mesenchymal stromal cell Mesenchymal stromal cells moderate to severe MSC MSCs multicentre NHS number Open-label outcome outlined oxygenation index patients patients with moderate Phase 1 phase 1 trial Phase 2 phase 2 trial Placebo placebo-controlled placebo-controlled trial Practice produced protocol randomised rationale receive recruited recruitment repair reported Reporting respiratory distress Respiratory distress syndrome Serious Adverse Events severe ARDS Standard stromal cell stromal cells Study protocol syndrome therapy Trial triple-blind umbilical Umbilical cord [DOI] 10.1186/s13063-022-06220-0 PMC 바로가기 [Article Type] Article