Sex-dependent effects of the uncompetitive N-methyl-D-aspartate receptor antagonist REL-1017 in G93A-SOD1 amyotrophic lateral sclerosis miceNeurology Original Research Published on 2024-05-032024-09-05 Journal: Frontiers in Neurology [Category] update2024, [키워드] ALS esmethadone neuronal plasticity NMDAR antagonism oxidative stress REL-1017 [DOI] 10.3389/fneur.2024.1384829 PMC 바로가기 [Article Type] Neurology Original Research
Combined Regulatory T-Lymphocyte and IL-2 Treatment Is Safe, Tolerable, and Biologically Active for 1 Year in Persons With Amyotrophic Lateral SclerosisRandomized Controlled Trial Published on 2022-08-292022-10-05 Journal: Neurology® neuroimmunology & neuroinflammation [Category] 바이오마커, 임상, [키워드] 1:1 ALS assigned autologous average baseline changed class classification clinical study Combined conducted COVID-19 pandemic Disease progression Dose escalation dose-escalation doses effective elevated enrolled Evidence extension Good group help IL-2 Inflammation injection intervals Lateral Sclerosis LDL Leukapheresis low-density marker matching placebo Open-label oxidative stress oxidized participant Patient Person Placebo Practice progression provide Randomized controlled trial Randomly RCT receive receptor Regulatory reliability Safe slow disease suppressive function T-lymphocyte therapy Treatment Treg Tregs Year [DOI] 10.1212/NXI.0000000000200019 PMC 바로가기 [Article Type] Randomized Controlled Trial
Covid-19 threat and coping: application of protection motivation theory to the pandemic experiences of people affected by amyotrophic lateral sclerosisCovid-19 위협과 대처: 근위축성 측삭 경화증의 영향을 받는 사람들의 전염병 경험에 보호 동기 이론 적용Article Published on 2022-04-122022-09-11 Journal: BMC Neurology [Category] COVID19(2023년), SARS, 변종, [키워드] adaptation affected ALS Amyotrophic lateral sclerosis Analysis analyzed approach benefit Canada Care clinical care communication contributed coping COVID 19 COVID-19 infection COVID-19 pandemic determine Emergency Emergency planning engage expressed Families family Family caregivers finding flexible group Health health authorities health systems Healthcare systems high risk identify Infection information Interaction introduced investigated lack Lateral Sclerosis media Medical care mitigate motivation outcome pandemic Pandemics participant pathway Patient patients populations professional protection Protective Protective motivation theory. provided public health recommendation recruited Region Support Telemedicine theory threat Vaccines variant [DOI] 10.1186/s12883-022-02662-w PMC 바로가기 [Article Type] Article
Operation of a triage committee for advanced life support during the COVID-19 pandemicObservational Study Published on 2022-03-162022-10-05 Journal: Philosophy, Ethics, and Humanities in Medicine : P [Category] 임상, [키워드] ADP affected age ALS candidate Clinical characteristics clinical criteria Comorbidity COVID-19 COVID-19 pandemic decision Decision-making determine effective Ethics Ethics Committees/Consultation evaluated First wave foundation functional Health help implementation include involved less male measure median Older operation Other participated Patient patients evaluated physician Public receive resources SARS CoV-2 severe respiratory failure Spain Support the patient Triage university [DOI] 10.1186/s13010-022-00117-1 PMC 바로가기 [Article Type] Observational Study
Amyotrophic lateral sclerosis caregiver burden and patients’ quality of life during COVID-19 pandemicArticle Published on 2022-02-012023-07-06 Journal: Amyotrophic lateral sclerosis & frontotemporal degeneration [Category] COVID19(2023년), [키워드] ALS caregiver burden. COVID-19 pandemic QoL [DOI] 10.1080/21678421.2021.1912772
How to Maintain Safety and Maximize the Efficacy of Cardiopulmonary Resuscitation in COVID-19 Patients: Insights from the Recent GuidelinesReview Published on 2021-11-302022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Affect Algorithm ALS Cardiac arrest Cardiopulmonary Cardiopulmonary resuscitation caused condition coronavirus 2 COVID-19 COVID-19 pandemic COVID-19 patients CPR detrimental effect Efficacy globe Government guideline healthcare Healthcare system Hospital admission IHCA insight Mortality novel coronavirus disease OHCA pandemic pathophysiology Patient patients pediatric recent recommendation recommendations remained respiratory Resuscitation Safety SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected patients Support Transmission [DOI] 10.3390/jcm10235667 PMC 바로가기 [Article Type] Review
SIMpLE: A Mobile Cloud-Based System for Health Monitoring of People with ALS †Article Published on 2021-10-302022-10-29 Journal: Sensors (Basel, Switzerland) [Category] Coronavirus, MERS, SARS, [키워드] addition affected ALS Care caused chronic disease Chronic diseases cloud Complication cortical COVID 19 Disabled disease ECG electrocardiographic EMG Health hospitals Infection Lateral Sclerosis mHealth Mobile MONITOR monitoring motor neurons neurodegenerative neurophysiological monitoring pandemic paralysis pathology Patient patients Prevent remote monitoring risk of COVID-19 secure System teleconsulting the disease voluntary muscle [DOI] 10.3390/s21217239 PMC 바로가기 [Article Type] Article
Entropy and Fractal Dimension Study of the TDP-43 Protein Low Complexity Domain Sequence in ALS Disease Severity and SARS-CoV-2 Gene Sequences in Virulence VariabilityArticle Published on 2021-08-122022-10-31 Journal: Information Sciences [Category] COVID-19, [키워드] ALS Amino acid Analysis Cell codon usage complexity computational analysis computational method conducted correlation coefficient cryo-EM defined described dimension domain Entropy extreme Fractal Fractal dimension gene sequence Genes HAR1 highest information low complexity domain sequence lowest nucleotide produced Protein protein sequence reported SARS-CoV-2 sequence TDP-43 Vaccine design viability virulence virulent Znf521 [DOI] 10.3390/e23081038 PMC 바로가기 [Article Type] Article
The experience of children with a parent suffering from Amyotrophic Lateral Sclerosis during the COVID-19 pandemicCovid-19 Pandemic 동안 근 위축성 측면 경화증으로 고통받는 부모가있는 어린이의 경험Article Published on 2021-08-062022-09-10 Journal: Scientific Reports [Category] MERS, 치료제, [키워드] Affect ALS Amyotrophic lateral sclerosis assessment attachment behavioural children concept control group COVID-19 pandemic death DESSA detect difficulty Health care Health services involved Italian Lateral Sclerosis lockdown Mental negative negative affect parent Participants problem Psychology public health Quality of life reduced representation Resilience scale schedule security self Self Concept strength student variable [DOI] 10.1038/s41598-021-95338-3 PMC 바로가기 [Article Type] Article
An Approved Landing Site (ALS) improves the logistics of interhospital transfer of critically ill patients by helicopterCommentary Published on 2021-08-032022-10-29 Journal: Scandinavian Journal of Trauma, Resuscitation and [Category] Coronavirus, MERS, SARS, [키워드] ad-hoc ALS approved Characteristics condition COVID-19 pandemic Critical care Critically ill patient described hospital hospital resource ICU IMPROVE landing Netherland Netherlands occurred Patient receiving recorded required Safe Site supplementary material transfer Transport [DOI] 10.1186/s13049-021-00894-2 PMC 바로가기 [Article Type] Commentary