alveolar fluid clearance – Communicable Diseases Research

MECHANISMS OF IMPAIRED ALVEOLAR FLUID CLEARANCE

Article

Published on 2023-10-042024-09-05
Journal: Anatomical record (Hoboken, N.J. : 2007) [Category] update2024,

Human placenta-derived amniotic epithelial cells as a new therapeutic hope for COVID-19-associated acute respiratory distress syndrome (ARDS) and systemic inflammation

COVID-19 관련 급성 호흡 곤란 증후군(ARDS) 및 전신 염증에 대한 새로운 치료 희망으로서의 인간 태반 유래 양막 상피 세포

Review

Published on 2022-03-252022-09-11
Journal: Stem Cell Research & Therapy [Category] SARS, 변종, 유전자 메커니즘,

[키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus aldosterone alveolar fluid clearance amniotic Amniotic membrane angiotensin ARDS cause Cell complications complications of COVID-19 consequence Consequences coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 damaged death drug delivery system Efficacy epithelial cell epithelial cells Epithelial stem cells Exosome Exosomes feature fibrosis hAEC Human immune system immunomodulation immunomodulatory effect immunomodulatory effects mechanism membrane multi-organ failure organ organs Prevent question reaction reduce regeneration regenerative medicine Regulation Renin renin-angiotensin-aldosterone system respiratory distress SARS-CoV-2 serious complication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 stem cells suggested syndrome systemic inflammation therapeutic Therapeutic approach therapeutic option These cells thrombotic Thrombotic events viral variant
[DOI] 10.1186/s13287-022-02794-3 PMC 바로가기 [Article Type] Review

Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate

Research Article

Published on 2021-11-232022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS, SARS,

Extracellular Vesicle-Based Therapy for COVID-19: Promises, Challenges and Future Prospects

Review

Published on 2021-10-012022-10-28
Journal: Biomedicines [Category] COVID-19,

Current Status of Cell-Based Therapies for COVID-19: Evidence From Mesenchymal Stromal Cells in Sepsis and ARDS

Immunology

Published on 2021-10-012022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

Molecular mechanisms of Na,K-ATPase dysregulation driving alveolar epithelial barrier failure in severe COVID-19

Editorial

Published on 2021-06-012023-06-16
Journal: American journal of physiology. Lung cellular and [Category] MERS, SARS,

[키워드] alveolar epithelium alveolar fluid clearance COVID-19 lung edema Na,K-ATPase SARS-CoV-2
[DOI] 10.1152/ajplung.00056.2021 PMC 바로가기 [Article Type] Editorial

Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles in COVID-19-induced ARDS: Mechanisms of action, research progress, challenges, and opportunities

Review

Published on 2021-04-282022-11-01
Journal: International immunopharmacology [Category] COVID-19, MERS,

[키워드] KGF, Keratinocyte Growth Factor LDH, Lactate Dehydrogenase LIF, Leukemia Inhibitory Factor LPS, Lipopolysaccharide MERS-CoV, The Middle East Respiratory Syndrome Coronavirus MIP-2, Macrophage Inflammatory Protein-2 MOD, Multiple Organ Dysfunction MSC, Mesenchymal Stromal/Stem Cell MVB, Multi Vesicle Body NGF, Nerve Growth Factor NK cell, Natural Killer Cell PDGF, Platelet-Derived Growth Factor PGE2, Prostaglandin E2 ROS, Reactive Oxygen Species SARS-CoV, Severe Acute Respiratory Syndrome Coronavirus SPA, Surfactant Protein A SPC, Surfactant Protein C TGF-β, Transforming Growth Factor-Β Th, T Helper TMPRSS2, Transmembrane Protease Serine 2 TNF- α, Tumor Necrosis Factor- Α UC-MSC, Umbilical Cord MSC VEGF, Vascular Endothelial Growth Factor WBC, White Blood Cell Abstract ACE2, angiotensin-converting enzyme 2 acute respiratory distress acute respiratory distress syndrome AD-MSC, Adipocyte-Derived MSC administration AFC, Alveolar Fluid Clearance ALI, Acute Lung Injury ALT, alanine aminotransferase alveolar fluid clearance Ang-1, Angiopoietin-1 Anti-inflammatory effects approach ARDS ARDS, acute respiratory distress syndrome AST, aspartate aminotransferase AT II, Type II Alveolar Epithelial attenuate BDNF, Brain-Derived Neutrophilic Factor BM-MSC, Bone Marrow MSC caused Cell China Coagulopathy COPD, Chronic obstructive pulmonary disease coronavirus disease COVID-19 COVID-19 patients CRP, C-reactive protein CT, Computerized Tomography Cytokine storm DC, dendritic cell DIC, disseminated intravascular coagulation endothelial ENhance EV, extracellular vesicle Evidence EVs extracellular vesicle Extracellular vesicles global public health GVHD, Graft-versus-host disease hESC, Human Embryonic Stem Cell HGF, Hepatocyte Growth Factor HIF1-α, Hypoxia-Induced Factor 1-Α IFN, interferon immune response immunomodulation IMRC, Immunity and Matrix-Regulatory Cell incidence IPF, Idiopathic pulmonary fibrosis ISG, Interferon-Stimulated Genes IV, Intravenous lung injuries mechanism Mesenchymal stem cells MSC MSC therapy MSCs Novel coronavirus Probability Research resolved SARS-CoV-2 severity suggested syndrome therapeutic Therapeutic approach Treatment viral infections worldwide pandemic Wuhan
[DOI] 10.1016/j.intimp.2021.107694 PMC 바로가기 [Article Type] Review

Potential application of mesenchymal stem cells and their exosomes in lung injury: an emerging therapeutic option for COVID-19 patients

Review

Published on 2020-10-152022-10-29
Journal: Stem Cell Research & Therapy [Category] COVID-19, MERS, SARS,

[키워드] acute lung injury alveolar fluid clearance applicability approved ARDS characterized clinical study clinical trial clinical trials Consensus correlation COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients effective effective therapy Efficacy endothelial ENhance epithelial Exosome global public health highlight impacted Infection International less lung mechanism of action mesenchymal stem cell MSC MSC therapy MSCs Pneumonia Potential promote reduce Registered risk Safe SARS-CoV-2 stem cell stem cells the cytokine storm the SARS-CoV-2 therapeutic therapeutic effect therapeutic option therapy Thromboembolism treat treating COVID-19 patients Treatment unique
[DOI] 10.1186/s13287-020-01963-6 PMC 바로가기 [Article Type] Review

Mesenchymal stem cell therapy for acute respiratory distress syndrome: from basic to clinics

급성호흡곤란증후군의 간엽줄기세포치료제: 기초부터 임상까지

Review

Published on 2020-06-092022-09-10
Journal: Protein & Cell [Category] MERS, SARS, 비임상,

[키워드] 2019 novel coronavirus 2019 novel coronavirus disease acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alveolar fluid clearance anti-apoptotic Anti-inflammatory approaches ARDS Bacterial breath caused Cell cell damage Cell therapy China clinical study clinics coronavirus coronavirus disease COVID-19 COVID-19 patient develop disease disrupt distal Effects Efficacy ENhance epithelial epithelial cell event Extracellular vesicles Factor high mortality intrinsic limit lung mechanism mesenchymal stem cell Mesenchymal stem cells morbidity MSC MSC therapy multiple organ failure Novel coronavirus novel coronavirus disease occurred optimization Organ failure organ injury paracrine pathophysiological patients with ARDS Pneumonia promote pulmonary endothelial respiratory respiratory distress SARS-CoV-2 SARS-CoV-2-infected patient SARS-CoV-2-infected patients severe acute respiratory syndrome Coronavirus severe pneumonia stem cell supportive care survival syndrome therapeutic therapy variety
[DOI] 10.1007/s13238-020-00738-2 PMC 바로가기 [Article Type] Review

Rationale for the clinical use of adipose-derived mesenchymal stem cells for COVID-19 patients

코로나19 환자를 위한 지방유래 중간엽줄기세포의 임상적 사용 근거

Review

Published on 2020-05-182022-09-10
Journal: Journal of Translational Medicine [Category] MERS, SARS, 비임상,

[키워드] acute respiratory distress acute respiratory distress syndrome administration alveolar fluid clearance animal model animal models antimicrobial ARDS ASC benefit breath capital city Cell China Clinical studies clinical study Clinical use Comorbidity coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 outbreak COVID-19 patient Critical demonstrated distress edema effective Ex vivo Fever global pandemic globe greater Health Organization healthcare high mortality rate hospital resources human clinical trials human lung hypoxia illness immune response immune responses immunomodulatory activities in some in vivo Inflammation inhibit intravenous Intravenous administration intravenous route lead Local lung lung damage Lungs majority Mesenchymal stem cells molecules morbidity morbidity and mortality MSC MSCs multi-organ failure Multiple Novel coronavirus older patients Pain Patient patient mortality per day Pneumonia pulmonary disease Pulmonary edema Pulmonary function rationale reduce reduced respiratory respiratory distress respiratory symptoms risk Safe SARS-CoV-2 SARS-COV-2 infection severe disease Severe respiratory distress stem cell stem cells syndrome therapeutic option therapy Travel Treatment treatment of COVID-19 Viral viral outbreak viral respiratory with COVID-19 World Health Organization Wuhan
[DOI] 10.1186/s12967-020-02380-2 PMC 바로가기 [Article Type] Review