Murine alveolar macrophages rapidly accumulate intranasally administered SARS-CoV-2 Spike protein leading to neutrophil recruitment and damageImmunology and Inflammation Published on 2024-03-202024-09-05 Journal: eLife [Category] update2024, [키워드] alveolar macrophage Important mouse NETosis neutrophil PBMC SARS-CoV-2 Siglec Solid Spike protein Viral vector [DOI] 10.7554/eLife.86764 PMC 바로가기 [Article Type] Immunology and Inflammation
Murine Alveolar Macrophages Rapidly Accumulate Intranasally Administered SARS-CoV-2 Spike Protein leading to Neutrophil Recruitment and DamageArticle Published on 2023-12-042024-09-05 Journal: bioRxiv [Category] update2024, [키워드] alveolar macrophage NETosis neutrophil SARS-CoV-2 Siglec Spike protein [DOI] 10.1101/2023.03.13.532446 PMC 바로가기 [Article Type] Article
Low BALF CD4 T cells count is associated with extubation failure and mortality in critically ill covid-19 pneumonia낮은 BALF CD4 T 세포 수는 중환자의 covid-19 폐렴에서 발관 실패 및 사망률과 관련이 있습니다Article Published on 2022-12-012022-09-11 Journal: Annals of Medicine [Category] 바이오마커, 진단, [키워드] affected alveolar alveolar macrophage analysed average BALF BALF CD4 T-cells count baseline Biomarker bivariate analysis Bronchoalveolar lavage fluid caspase caspase-3 cause CD4 CD4 T cell CD4 T-cell Characteristics clinical Clinical characteristics conducted COVID-19 COVID-19 patients COVID-19 pneumonia COVID-19 pneumonia patient COVID-19 pneumonia patients Critically ill critically ill COVID-19 patients Critically ill COVID-19 pneumonia D-dimer D-dimer level eight enrolled extubation failure. groups help IL-17 IL-6 immunopathology IMPROVE Indonesia intubation Invasive mechanical ventilation Laboratory lung Macrophage material Mortality no significant difference no significant differences outcome Patient performed Pneumonia profile Referral reported right lung severe pneumonia severity significant differences significantly survived T-cells Tertiary Tregs understanding was performed were measured [DOI] 10.1080/07853890.2022.2095012 PMC 바로가기 [Article Type] Article
How Do Anti-SARS-CoV-2 mRNA Vaccines Protect from Severe Disease?Article Published on 2022-09-082022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] adaptive alveolar alveolar macrophage Alveolar macrophages antiviral immunity approach benefit consequence COVID-19 Cytokine storm develop diffusion disease dissemination Efficacy elicited epithelial cell expected experimental evidence Extracellular Factor feature Host immune response immune function inhibitory effect intramuscularly Macrophage mechanism messenger mRNA mRNA vaccine mRNA vaccines mucosa other tissue outcome Pathogenesis Prophylaxis Protein Quantitative respiratory respiratory symptom respiratory tracts SARS-CoV-2 severe disease spike Spread TGF-β the cytokine storm upper respiratory tracts Vaccine viral replication virus while [DOI] 10.3390/ijms231810374 PMC 바로가기
Cell tropism and viral clearance during SARS-CoV-2 lung infectionSARS-CoV-2 폐 감염 중 세포 친화성 및 바이러스 제거Article Published on 2022-08-012022-09-11 Journal: Pathology, research and practice [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Alpha alveolar macrophage Alveolar macrophages autopsy studies B.1.1.529 B.1.1.7 B.1.617.2 capillary microthrombosis caused Cellular target COVID-19 debate Delta detect driving Endothelial cell endothelial cells Endothelialitis epithelial cells fatal COVID-19 high viral load identify In situ hybridization infected cell key factor Lung infection lung tissue macrophages Microthrombosis omicron original virus strain Patient protein-coding RNA pulmonary reported RNA SARS-CoV-2 SARS-COV-2 infection severe COVID-19 spike Spike protein Time-course. variants variants of concern viral clearance viral infection Viral load Viral RNA was used [DOI] 10.1016/j.prp.2022.154000 PMC 바로가기 [Article Type] Article
Alveolar macrophages: Achilles’ heel of SARS-CoV-2 infection폐포 대식세포: SARS-CoV-2 감염의 아킬레스건Review Published on 2022-07-192022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 치료제, [키워드] Achille Acidic acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alveolar macrophage Alveolar macrophages alveoli Antiviral compound Antiviral compounds antiviral drug antiviral drugs can not caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytosol dampen death Degradation effort endosomal pH endosome Endosomes exploration facilitate gloom Immune cell immune cells individuals infected individuals initiate lysosomal macrophages modulation Neutralizing antibodies neutralizing antibody pandemic prophylactically Replication respiratory viruses SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus specificity Spread treat Vaccine viral escape viral mutation virus viruses [DOI] 10.1038/s41392-022-01106-8 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Achieves Immune Escape by Destroying Mitochondrial Quality: Comprehensive Analysis of the Cellular Landscapes of Lung and Blood Specimens From Patients With COVID-19SARS-CoV-2, 미토콘드리아 품질을 파괴하여 면역 탈출 달성: COVID-19 환자의 폐 및 혈액 표본의 세포 환경에 대한 종합 분석Article Published on 2022-07-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] activated activating alveolar alveolar epithelial cell alveolar epithelial cells alveolar macrophage Alveolar macrophages analyzed antiviral immunity B cell B cells blocked Blood calcium cell count Comprehensive coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients crossfire cytokine Cytokine storm dataset Defense Degradation energy metabolism epithelial epithelial cell epithelial cells escape exacerbated excessive inflammation explain expression Gene Expression HIF1a Host IFI27 immune immune cells Immune escape Inflammation inhibited Interaction interferon landscape lung tissue Lungs Macrophage macrophages manifestation MCU metabolic pathway metabolism Mitochondria mitochondrial mitochondrial fission mitochondrial functions mitochondrial quality. pathway patients with COVID-19 Perspective plasma pro-inflammatory Regulatory T cell regulatory T cells released Replication respiratory capacity resulting RNA-sequencing SARS-CoV-2 significant changes in Single-cell RNA-sequencing T cells target transformation Tregs type I viral infection [DOI] 10.3389/fimmu.2022.946731 PMC 바로가기 [Article Type] Article
Airway administration of bisphosphate and dexamethasone inhibits SARS-CoV-2 variant infection by targeting alveolar macrophages바이포스페이트와 덱사메타손의 기도 투여는 폐포 대식세포를 표적으로 하여 SARS-CoV-2 변이체 감염을 억제합니다Article Published on 2022-04-062022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] administration alveolar macrophage Dexamethasone Infection inhibit SARS-CoV-2 variant [DOI] 10.1038/s41392-022-00977-1 PMC 바로가기 [Article Type] Article
A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunityArticle Published on 2022-03-282023-06-14 Journal: Emerging Microbes & Infections [Category] Fulltext, 신종인플루엔자, [키워드] alveolar macrophage Influenza interferon Prophylactic respiratory syncytial virus [DOI] 10.1080/22221751.2022.2050951 PMC 바로가기
Inhalable SARS-CoV-2 Mimetic Particles Induce Pleiotropic Antigen Presentation흡입 가능한 SARS-CoV-2 모방 입자는 다면 발현 항원 제시를 유도합니다Article Published on 2022-03-142022-09-11 Journal: Biomacromolecules [Category] Coronavirus, SARS, 변종, [키워드] alveolar macrophage Alveolar macrophages carrier caused cellular Community Compliance coronavirus coronavirus disease Coronavirus disease 2019 death distribution elicit epithelial cells Evidence feature glycosaminoglycan IgA level immune cells immune response immune responses Immunity immunization in vitro less lung lung epithelial cell Lung epithelial cells macromolecular Macrophage macrophages mice Mimetic mucosa mucosal mutant nucleic acid Particle Pathogenesis peptide plasmids pleiotropic presentation respiratory tract SARS-CoV-2 single dose target the SARS-CoV-2 topography Vaccine Vaccine hesitancy viral antigens virion [DOI] 10.1021/acs.biomac.1c01447 PMC 바로가기 [Article Type] Article