Spatial and phenotypic heterogeneity of resident and monocyte-derived macrophages during inflammatory exacerbations leading to pulmonary fibrosisImmunology Original Research Published on 2024-07-192024-09-05 Journal: Frontiers in immunology [Category] update2024, [키워드] Alveolar macrophages alveolar type-2 cell apolipoprotein-E fibronectin1 Monocyte-derived macrophages osteopontin1 pulmonary fibrosis surfactant protein-C I73T mutant [DOI] 10.3389/fimmu.2024.1425466 PMC 바로가기 [Article Type] Immunology Original Research
Cathepsin C from extracellular histone-induced M1 alveolar macrophages promotes NETosis during lung ischemia-reperfusion injuryResearch Paper Published on 2024-06-062024-09-05 Journal: Redox Biology [Category] update2024, [키워드] Alveolar macrophages Cathepsin C Lung ischemia-reperfusion injury NADPH oxidase NETosis [DOI] 10.1016/j.redox.2024.103231 PMC 바로가기 [Article Type] Research Paper
Combined regulation of pro-inflammatory cytokines production by STAT3 and STAT5 in a model of B. pertussis infection of alveolar macrophagesarticle Published on 2023-09-302024-09-01 Journal: Frontiers in immunology [Category] 백일해, [키워드] Alveolar macrophages Bordetella pertussis Cytokines Infection STAT proteins [Article Type] article
Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETEArticle Published on 2023-01-042024-09-05 Journal: Nature [Category] update2024, [키워드] Alveolar macrophages viral infection [DOI] 10.1038/s41586-022-05660-7 PMC 바로가기 [Article Type] Article
Intracellular survival of Streptococcus pneumoniae in human alveolar macrophages is augmented with HIV infectionarticle Published on 2022-09-302024-09-01 Journal: Frontiers in immunology [Category] 폐렴구균 감염증, [키워드] Alveolar macrophages HIV intracellular killing lung Streptococcus pneumoniae [Article Type] article
How Do Anti-SARS-CoV-2 mRNA Vaccines Protect from Severe Disease?Article Published on 2022-09-082022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] adaptive alveolar alveolar macrophage Alveolar macrophages antiviral immunity approach benefit consequence COVID-19 Cytokine storm develop diffusion disease dissemination Efficacy elicited epithelial cell expected experimental evidence Extracellular Factor feature Host immune response immune function inhibitory effect intramuscularly Macrophage mechanism messenger mRNA mRNA vaccine mRNA vaccines mucosa other tissue outcome Pathogenesis Prophylaxis Protein Quantitative respiratory respiratory symptom respiratory tracts SARS-CoV-2 severe disease spike Spread TGF-β the cytokine storm upper respiratory tracts Vaccine viral replication virus while [DOI] 10.3390/ijms231810374 PMC 바로가기
Cell tropism and viral clearance during SARS-CoV-2 lung infectionSARS-CoV-2 폐 감염 중 세포 친화성 및 바이러스 제거Article Published on 2022-08-012022-09-11 Journal: Pathology, research and practice [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Alpha alveolar macrophage Alveolar macrophages autopsy studies B.1.1.529 B.1.1.7 B.1.617.2 capillary microthrombosis caused Cellular target COVID-19 debate Delta detect driving Endothelial cell endothelial cells Endothelialitis epithelial cells fatal COVID-19 high viral load identify In situ hybridization infected cell key factor Lung infection lung tissue macrophages Microthrombosis omicron original virus strain Patient protein-coding RNA pulmonary reported RNA SARS-CoV-2 SARS-COV-2 infection severe COVID-19 spike Spike protein Time-course. variants variants of concern viral clearance viral infection Viral load Viral RNA was used [DOI] 10.1016/j.prp.2022.154000 PMC 바로가기 [Article Type] Article
Alveolar macrophages: Achilles’ heel of SARS-CoV-2 infection폐포 대식세포: SARS-CoV-2 감염의 아킬레스건Review Published on 2022-07-192022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 치료제, [키워드] Achille Acidic acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alveolar macrophage Alveolar macrophages alveoli Antiviral compound Antiviral compounds antiviral drug antiviral drugs can not caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytosol dampen death Degradation effort endosomal pH endosome Endosomes exploration facilitate gloom Immune cell immune cells individuals infected individuals initiate lysosomal macrophages modulation Neutralizing antibodies neutralizing antibody pandemic prophylactically Replication respiratory viruses SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus specificity Spread treat Vaccine viral escape viral mutation virus viruses [DOI] 10.1038/s41392-022-01106-8 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Achieves Immune Escape by Destroying Mitochondrial Quality: Comprehensive Analysis of the Cellular Landscapes of Lung and Blood Specimens From Patients With COVID-19SARS-CoV-2, 미토콘드리아 품질을 파괴하여 면역 탈출 달성: COVID-19 환자의 폐 및 혈액 표본의 세포 환경에 대한 종합 분석Article Published on 2022-07-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] activated activating alveolar alveolar epithelial cell alveolar epithelial cells alveolar macrophage Alveolar macrophages analyzed antiviral immunity B cell B cells blocked Blood calcium cell count Comprehensive coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients crossfire cytokine Cytokine storm dataset Defense Degradation energy metabolism epithelial epithelial cell epithelial cells escape exacerbated excessive inflammation explain expression Gene Expression HIF1a Host IFI27 immune immune cells Immune escape Inflammation inhibited Interaction interferon landscape lung tissue Lungs Macrophage macrophages manifestation MCU metabolic pathway metabolism Mitochondria mitochondrial mitochondrial fission mitochondrial functions mitochondrial quality. pathway patients with COVID-19 Perspective plasma pro-inflammatory Regulatory T cell regulatory T cells released Replication respiratory capacity resulting RNA-sequencing SARS-CoV-2 significant changes in Single-cell RNA-sequencing T cells target transformation Tregs type I viral infection [DOI] 10.3389/fimmu.2022.946731 PMC 바로가기 [Article Type] Article
Inhalable SARS-CoV-2 Mimetic Particles Induce Pleiotropic Antigen Presentation흡입 가능한 SARS-CoV-2 모방 입자는 다면 발현 항원 제시를 유도합니다Article Published on 2022-03-142022-09-11 Journal: Biomacromolecules [Category] Coronavirus, SARS, 변종, [키워드] alveolar macrophage Alveolar macrophages carrier caused cellular Community Compliance coronavirus coronavirus disease Coronavirus disease 2019 death distribution elicit epithelial cells Evidence feature glycosaminoglycan IgA level immune cells immune response immune responses Immunity immunization in vitro less lung lung epithelial cell Lung epithelial cells macromolecular Macrophage macrophages mice Mimetic mucosa mucosal mutant nucleic acid Particle Pathogenesis peptide plasmids pleiotropic presentation respiratory tract SARS-CoV-2 single dose target the SARS-CoV-2 topography Vaccine Vaccine hesitancy viral antigens virion [DOI] 10.1021/acs.biomac.1c01447 PMC 바로가기 [Article Type] Article