Zinc pyrithione is a potent inhibitor of PL Pro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication아연 피리티온은 SARS-CoV-2 진입 및 복제를 생체 외에서 억제하는 PL Pro 및 카텝신 L 효소의 강력한 억제제입니다.Article Published on 2022-12-012022-09-11 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] COVID19(2023년), SARS, 치료제, [키워드] analogue Anti-SARS-CoV-2 Activity Antiviral antiviral activity Antiviral agents assays cathepsin L comparable complex complexes contrary COVID-19 effective enzyme Enzymes evaluated Ex vivo expressed human lung tissue in vitro inhibition inhibitor involved Ligand media Pro pyrithione Replication ruthenium SARS-CoV-2 SARS-CoV-2 entry stability synthesised therapeutic therapeutic agent Zinc Zinc complexes Zinc pyrithione [DOI] 10.1080/14756366.2022.2108417 PMC 바로가기 [Article Type] Article
Towards Covid-19 TMPRSS2 enzyme inhibitors and antimicrobial agents: Synthesis, antimicrobial potency, molecular docking, and drug-likeness prediction of thiadiazole-triazole hybridsResearch article Published on 2022-11-012022-10-05 Journal: Journal of Molecular Structure [Category] 치료제, [키워드] 1 2 3 3-Triazoles 4-Thiadiazole analogue antimicrobial activity Bacillus subtilis binding affinity Candida albican candidate chalcone chloride Compound COVID-19 drug-likeness enzyme Escherichia coli exhibited FIVE Hydrazonoyl halides identify in silico in vitro inhibitor molecular docking pathogen Prevent proliferation Pseudomonas aeruginosa screened Staphylococcus aureus submitted synthesis synthesised therapeutic activity TMPRSS2 TMPRSS2 enzyme transmembrane serine protease Treatment Vanillin was tested [DOI] 10.1016/j.molstruc.2022.133659 [Article Type] Research article
Optimization of the Prodrug Moiety of Remdesivir to Improve Lung Exposure/Selectivity and Enhance Anti-SARS-CoV-2 ActivityArticle Published on 2022-09-222022-11-15 Journal: Journal of medicinal chemistry [Category] SARS, 변종, 치료제, [키워드] Activation activity analogue antiviral activity antiviral drug antiviral potency Antiviral treatment Concentration COVID-19 COVID-19 patient Efficacy FDA-approved drug hamsters hydrolysis lack lung lung epithelial cell Lungs metabolite moiety NTP nucleoside optimization Patient patients plasma Premature prodrug reducing Remdesivir severe symptom severe symptoms tissue treat variants of SARS-CoV-2 [DOI] 10.1021/acs.jmedchem.2c00758 PMC 바로가기
A Retinol Derivative Inhibits SARS-CoV-2 Infection by Interrupting Spike-Mediated Cellular EntryArticle Published on 2022-08-302022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome all-trans retinoic acid analogue antibody antiviral activity Apoptosis ATRA bind binding Cell cellular cellular entry Compound coronavirus Coronaviruses COVID-19 derivative disease Efficacy etiological agent feasibility global pandemic growth human cell line hydrophobic pocket include inhibitory Interaction Interrupting life-threatening coronavirus disease Lower respiratory tract mechanism metabolite organ systems Organoid pharmacological physiological prevention of COVID-19 RBD Receptor binding domain regulate reported retinol S trimer SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants Spike protein structural mechanism. the SARS-CoV-2 therapeutic trimer Vaccine vitamin A [DOI] 10.1128/mbio.01485-22 PMC 바로가기
A Systematic Study on the Optimal Nucleotide Analogue Concentration and Rate Limiting Nucleotide of the SARS-CoV-2 RNA-Dependent RNA PolymeraseSARS-CoV-2 RNA 의존성 RNA 중합효소의 최적 뉴클레오티드 유사체 농도 및 속도 제한 뉴클레오티드에 대한 체계적인 연구Article Published on 2022-07-272022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] adenosine analogue Antiviral compounds antiviral efficacy approved assays clinically competition complex Concentration condition cordycepin coronavirus COVID-19 COVID-19 pandemic COVID-19 treatment drug effective Efficiency EIDD-2801 element GS-443902 GS-5734 GTP in vitro new SARS-CoV-2 NUC-7738 nucleoside nucleotide nucleotides physiological Rate RdRP Remdesivir Repurposed drug RNA RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 replication sensitivity the SARS-CoV-2 Treatment [DOI] 10.3390/ijms23158302 PMC 바로가기 [Article Type] Article
Long-term functioning status of COVID-19 survivors: a prospective observational evaluation of a cohort of patients surviving hospitalisationObservational Study Published on 2022-07-272022-10-04 Journal: BMJ Open [Category] COVID19(2023년), SARS, 임상, [키워드] 24 hour activities acute SARS-CoV-2 infection age analogue Analysis Anxiety assessment Borg Brazil breathlessness Care chronic clinical manifestations cohort of patient COVID-19 daytime Depression disability fatigue functional Functional status handgrip strength hospital hospital discharge hospitalisation hospitalised illness Independence indicated Insomnia Insomnia Severity Index intake Invasive mechanical ventilation investigated Long-term condition measure Medical Research Council MOST MRC muscle oral Pain participant prevalent prospective observational study public health reduced rehabilitation medicine reported required scale schedule sleepiness Sociodemographic Stand strength survivor Survivors Test treat university hospital Visual weakness WHO [DOI] 10.1136/bmjopen-2021-057246 PMC 바로가기 [Article Type] Observational Study
Identifying Structural Features of Nucleotide Analogues to Overcome SARS-CoV-2 Exonuclease ActivitySARS-CoV-2 엑소뉴클레아제 활성을 극복하기 위한 뉴클레오티드 유사체의 구조적 특징 확인Article Published on 2022-06-282022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activity analogue animal models antivirals candidate Cell culture Combination conserved Coronaviruses COVID-19 therapeutics Critical develop drugs drugs targeting effective Effectiveness evaluate evaluated excision ExoN exonuclease feature group identifying in vitro result inhibit SARS-CoV-2 inhibitor inhibitors new SARS-CoV-2 nucleotide nucleotide analogue nucleotide analogues nucleotides offer Proofreading RdRP RdRp inhibitor reported RNA RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 variants selected sequence Spread the SARS-CoV-2 variants variety [DOI] 10.3390/v14071413 PMC 바로가기 [Article Type] Article
Diagnostic Concordance between the Visual Analogue Anxiety Scale (VAS-A) and the State-Trait Anxiety Inventory (STAI) in Nursing Students during the COVID-19 PandemicObservational Study Published on 2022-06-092022-10-04 Journal: International Journal of Environmental Research an [Category] 임상, [키워드] analogue Anxiety approach carried collected correlation COVID-19 COVID-19 pandemic cross-sectional detect determine diagnostic false positive rate faster FPR generate inventory Nursing nursing students positive rate Probability problem Quantitative Safe scale socio-demographic STAI state-trait anxiety inventory student threshold variable Visual Visual Analogue Scale visual analogue scale. [DOI] 10.3390/ijerph19127053 PMC 바로가기 [Article Type] Observational Study
2′- and 3′-Ribose Modifications of Nucleotide Analogues Establish the Structural Basis to Inhibit the Viral Replication of SARS-CoV-2뉴클레오티드 유사체의 2'- 및 3'-리보스 변형은 SARS-CoV-2의 바이러스 복제를 억제하는 구조적 기초를 확립합니다Article Published on 2022-05-122022-09-11 Journal: The journal of physical chemistry letters [Category] COVID19(2023년), SARS, 치료제, [키워드] active site adenosine Affect analogue Antiviral Basis evaluated extension inhibition Modification molecular molecular dynamics nucleotide nucleotide analogue nucleotide analogues Protein provide RdRP Remdesivir ribose RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp shown stability Structural analysis Treatment [DOI] 10.1021/acs.jpclett.2c00087 PMC 바로가기 [Article Type] Article
New Psychoactive Substances and receding COVID-19 pandemic: really going back to “normal”?새로운 정신 활성 물질과 코로나19 대유행 퇴조: 정말 "정상"으로 돌아가는가?Article Published on 2022-05-112022-09-11 Journal: Acta bio-medica : Atenei Parmensis [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Abuse agency analogue Analysis appear approach arising available data benzimidazole can not Case report case reports Characteristics check circumvent clonitazene club compounds COVID-19 COVID-19 pandemic criminal criminality Dark Web death deaths derivative detectable detection system disorders diversion dosages drug Drug Abuse early stage early stages ecosystem Effect effective Effects effort Endemic etonitazene European Exacerbation fatality fentanyl FIVE form Health Service Health services healthcare implicated implication increasingly information Interaction involved isotonitazene less magnitude mechanism media metonitazene mistake Mortality New nine NMR NPs opioid opioids Opioids abuse overdose pandemic Probing public health public health emergency Public health responses receptor reduction Reduction potential replicate Research resource rising risk Scientific community seeking selected significantly more social media Still Stress substance substance abuse supply supply and demand Surveillance the SARS-CoV-2 traffickers turn urgency user experience variants web-based platform X-ray diffraction [DOI] 10.23750/abm.v93i2.13008 PMC 바로가기 [Article Type] Article