Relationship between gene expression patterns from nasopharyngeal swabs and serum biomarkers in patients hospitalized with COVID-19, following treatment with the neutralizing monoclonal antibody bamlanivimab
중화 단일클론항체 밤라니비맙 치료 후 코로나19로 입원한 환자의 비인두 면봉 유전자 발현 패턴과 혈청 바이오마커 간의 관계
Randomized Controlled Trial
Published on
Journal: Journal of Translational Medicine [Category] SARS, 바이오마커, 유전자 메커니즘, 임상, 진단, 치료기술,
Journal: Journal of Translational Medicine [Category] SARS, 바이오마커, 유전자 메커니즘, 임상, 진단, 치료기술,
[키워드] absence
Analysis
Analytes
antibody formation
Antibody Response
approach
bamlanivimab
Biomarker
biomarker signature
Biomarkers
Blood
change
changes in
circulation
clinical
clinical trial
Cohort
collected
connection
coronavirus
coronavirus 2
coronavirus disease
Coronavirus disease 2019
correlated
COVID-19
CXCL10
CXCL11
detect
disease
Elecsys
Gene Expression
gene expression pattern
groups
healthy control
healthy controls
Hospitalized
hospitalized COVID-19 patient
hospitalized COVID-19 patients
IFNγ
IgA
IgG titer
IgG titers
IgM
IL-6
immune response
immunoassay
immunological
implementation
Infection
Inflammatory
inflammatory protein
Inflammatory response
interferon response
Level
Luminex
MCP-3
MONITOR
monoclonal antibody
nasopharyngeal
Nasopharyngeal swab
nasopharyngeal swab sample
Nasopharyngeal swab samples
nasopharyngeal swabs
Neutralizing
not affect
not significantly different
observation
observations
Patient
patient population
patients
patients hospitalized
patients with COVID-19
peaked
Peripheral blood
Placebo
presence or absence
profile
Protein
Randomized
receive
reductions
reductions in
relationship
remained
repeated measure
respiratory
RNA sequencing
RNA-Seq
SARS-CoV-2
SARS-COV-2 infection
Seroconversion
serology
serum
serum biomarker
Serum protein
serum proteins
serum sample
serum samples
Severe acute respiratory syndrome
severe acute respiratory syndrome Coronavirus
severe acute respiratory syndrome coronavirus 2
similarities
single dose
systemic disease
therapeutic
Treatment
Treatment strategies
utility
viral-induced
was performed
was used
were used
while
with COVID-19
[DOI] 10.1186/s12967-022-03345-3 PMC 바로가기 [Article Type] Randomized Controlled Trial
[DOI] 10.1186/s12967-022-03345-3 PMC 바로가기 [Article Type] Randomized Controlled Trial