Gender trend of monkeypox virus infectionArticle Published on 2023-06-012023-06-10 Journal: Expert review of anti-infective therapy [Category] 원숭이두창, [키워드] Androgen receptor anti-infective therapy cofactors COVID-19 Gender immune response Monkeypox mpox Transcription [DOI] 10.1080/14787210.2023.2200163
Signal transducer and activator of transcription 3 cooperates with androgen receptor/cell cycle-related kinase signalling pathway in the progression of hepatitis B virus infection and gender differencesArticle Published on 2022-07-012023-06-12 Journal: Journal of viral hepatitis [Category] B형 간염, [키워드] Androgen receptor cell cycle-related kinase Chronic HBV infection Gender differences signal transducer and activator of transcription 3 [DOI] 10.1111/jvh.13699
The Impact of Androgen Deprivation Therapy on COVID-19 Illness in Men With Prostate Cancer전립선암이 있는 남성의 COVID-19 질병에 대한 안드로겐 결핍 요법의 영향Multicenter Study Published on 2022-05-022022-09-11 Journal: JNCI Cancer Spectrum [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI 95% confidence interval addition adjusted Affect Analysis androgen Androgen receptor androgens body mass body mass index Cell clinical disease cohorts Comorbidity COVID-19 COVID-19 diagnosis COVID-19 disease COVID-19 illness death defined demonstrated Deprivation epithelial cells evaluated Follow-up hazard ratio higher risk Hospitalization illness Impact Logistic lower risk mechanical ventilation median median age multicenter multicenter study multivariable Not demonstrated Older outcomes overall survival oxygen Oxygenation Patient patients performed Prostate cancer protease Regression model regulated respiratory epithelial cells retrospective cohort SARS-CoV-2 SARS-CoV-2 viral severe COVID-19 severe COVID-19 disease severe COVID-19 illness significantly statistical test statistically suggested supplemental oxygen survival therapy TMPRSS2 Treatment upregulated within 6 months [DOI] 10.1093/jncics/pkac035 PMC 바로가기 [Article Type] Multicenter Study
A Novel Glucocorticoid and Androgen Receptor Modulator Reduces Viral Entry and Innate Immune Inflammatory Responses in the Syrian Hamster Model of SARS-CoV-2 Infection새로운 글루코코르티코이드 및 안드로겐 수용체 조절제는 SARS-CoV-2 감염의 시리아 햄스터 모델에서 바이러스 진입 및 선천성 면역 염증 반응을 감소시킵니다Immunology Published on 2022-02-162022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료제, [키워드] 2019-nCoV 2019-nCoV/USA-WA1/2020 ACE2 acting Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered administration amplify Analysis androgen Androgen receptor angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 animal animals antagonist antagonists bind caused CD4 Cell clinical development Clinical studies clinical study coronavirus COVID-19 Critical days post-infection decrease Defense domain dose-dependent DPI Efficacy enzyme examined expression glucocorticoid Glucocorticoid receptor golden hamster hamster Host host defense humans IL-6 indicated infiltration Inflammation inflammatory lung injury Inflammatory response Innate innate immune Innate immunity intranasally lack lung Lung histopathology Lung injury lung tissue Macrophage macrophages mechanism mechanism of action Model modulator molecular docking studies Molecular docking study novel oral administration outcome patients Phylogenetic analysis positive Predictive Prevent progression protease Protein PT150 receptor receptors reduce regulated Replication replication of SARS-CoV-2 required Research respiratory response Result SARS – CoV – 2 SARS-CoV-2 SARS-COV-2 infection sequence identity Serine serine 2 severe acute respiratory syndrome Coronavirus shown strain surface protein T-cell T-cells TCID the cell therapeutic therapeutic efficacy Therapeutics tissue damage tissue injury TMPRSS2 transcriptional repressor transcriptionally transmembrane Treatment USA-WA1/2020 variants variants of SARS-CoV-2 Viral viral entry Viral load virus were infected [DOI] 10.3389/fimmu.2022.811430 PMC 바로가기 [Article Type] Immunology
Final Results of a Randomized, Placebo-Controlled, Two-Arm, Parallel Clinical Trial of Proxalutamide for Hospitalized COVID-19 Patients: A Multiregional, Joint Analysis of the Proxa-Rescue AndroCoV TrialEndocrinology/Diabetes/Metabolism Published on 2021-12-252022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 1:1 95% CI 95% confidence interval ACE2 addition all-cause mortality androgen Androgen receptor angiotensin-converting enzyme 2 antiandrogens Arm ARMS baseline Brazil clinical clinical trial COVID COVID-19 Day demonstrated discharge Drug efficacy effective Efficacy evaluate expression female Final highest hospital Hospital stay Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients improvement Inflammatory response interquartile range IQR joint material median mortality rate mortality rates North outcome outcomes oxygen pandemic performed Placebo placebo group preliminary report Prevent proxalutamide randomization randomized clinical trial RCT RCTs reduced reduction in Region Regulation Result risk ratio SARS-CoV-2 score Sepsis South statistical analysis statistically statistically significant stratified by sex study population subject the placebo group TMPRSS2 transmembrane protease serine 2 Trial usual care was performed WHO [DOI] 10.7759/cureus.20691 PMC 바로가기 [Article Type] Endocrinology/Diabetes/Metabolism
Host Sex Steroids Interact With Virus Infection: New Insights Into Sex Disparity in Infectious DiseasesMicrobiology Published on 2021-11-042022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] Androgen receptor caused Clinical practice complex coronavirus coronavirus disease Coronaviruses correlated COVID-19 develop disease Diseases disparity etiological Factor global pandemic HBV Hepatitis Hepatitis B virus herpesviruses hormone human viruses in viral Infection Infectious disease Influenza virus insight male male predominance male sex hormone Mortality New Pathogenesis pathway physiological function Placenta populations Prevalence proteolytically activate receptor representing reproductive responsible severity Sex sex hormone Signaling steroid tissue TMPRSS2 Transcription transmembrane transmembrane protease/serine subfamily member 2 treatment strategy viral infectious diseases virus entry virus infection viruses Zika virus ZIKV zone [DOI] 10.3389/fmicb.2021.747347 PMC 바로가기 [Article Type] Microbiology
A Plausible Link of TMPRSS2/ACE2/AR Signaling to Male Mortality during the COVID-19 Pandemic in the United StatesBrief Report Published on 2021-10-262022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] ACE2 age Androgen receptor Breast contribute correlated correlation COVID-19 COVID-19 pandemic death ESR1 expression fatality females Gender Gene Expression incidence incidence of COVID-19 Infection intestine involved low expression lung male males men metabolism morbidity Mortality observation opposite Prostate receptor Regulation SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral Signaling significantly higher Testosterone the United State The United States tissue TMPRSS2 viral infection women [DOI] 10.3390/pathogens10111378 PMC 바로가기 [Article Type] Brief Report
SELP Asp603Asn and severe thrombosis in COVID-19 malesSELP Asp603Asn 및 COVID-19 남성의 심각한 혈전증Letter to the Editor Published on 2021-08-162022-09-10 Journal: Journal of Hematology & Oncology [Category] MERS, SARS, 변종, [키워드] 95% CI Adhesion Molecule adjusted adjuvant therapy age androgen Androgen receptor Anti-selectin P monoclonal antibodies antibody Cell cell adhesion molecule coding variant Cohort confidence confidence interval COVID-19 D-dimer downregulated etiology Exome GEN-COVID homozygosity homozygote interval Logistic regression male Mortality Odds ratio Older P-selectin rationale receptor repurposing SARS-CoV-2 SELP Sequencing severity stratified by sex subject subjects supplementary material Testosterone the cell therapy Thromboembolism thrombosis thrombotic thrombotic risk Thrombus Venous Thromboembolism [DOI] 10.1186/s13045-021-01136-9 PMC 바로가기 [Article Type] Letter to the Editor
Do Anti-androgens Have Potential as Therapeutics for COVID-19?항안드로겐이 COVID-19 치료제로 가능성이 있습니까?Article Published on 2021-08-012022-09-11 Journal: Endocrinology [Category] SARS, 유전자 메커니즘, [키워드] ACE2 acting Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification androgen Androgen receptor androgens angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-androgen anti-androgens attachment Cancer cells Cell cells characterized cleavage clinical trial coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity Deprivation exhibiting expression followed by Gender glycoprotein Hospitalization Hypothesis increase infect Infection limitation lung male men mitigate molecular mortality rate offer patients Perspective Potential Prostate cancer protease receptor Recognition reducing responsible SARS-CoV-2 Serine serine 2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severity Sex sex differences spike glycoprotein Spike protein susceptibility Testosterone Therapeutics therapy TMPRSS2 TMPRSS2 expression transmembrane transmembrane protein viral spike virus women [DOI] 10.1210/endocr/bqab114 PMC 바로가기 [Article Type] Article
Proxalutamide Reduces the Rate of Hospitalization for COVID-19 Male Outpatients: A Randomized Double-Blinded Placebo-Controlled TrialMedicine Published on 2021-07-192022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 1:1 95% confidence interval acute respiratory distress Administered adverse events Androgen receptor androgenetic alopecia anti-androgen therapy antiandrogen antiandrogens Brazil conducted COVID-19 demonstrated determine double-blinded effective Follow-up Hospitalization intention-to-treat analysis men Patient patients died Placebo placebo group placebo-controlled clinical trial primary endpoint protective effect proxalutamide Randomized Rate receiving receptor recruited reported risk syndrome TMPRSS2 transmembrane protease serine 2 treated Treatment usual care was reduced with COVID-19 [DOI] 10.3389/fmed.2021.668698 PMC 바로가기 [Article Type] Medicine