ACE2 function in the pancreatic islet: Implications for relationship between SARS‐CoV‐2 and diabetesReview Article Published on 2021-10-022022-10-27 Journal: Acta physiologica (Oxford, England) [Category] COVID-19, [키워드] ACE2 addition angiotensin‐converting enzyme 2 Beta cells Cell cell physiology cells COVID‐19 patient COVID‐19 diabete diabetes dissect Effect Endocrine enzyme expressed expression Factor Glucose glucose homoeostasis homoeostasis host cells in vitro infect Injury insulin Insulin sensitivity islet islets lung metabolism molecular molecular mechanism pancrea pancreatic pancreatic islet Pathogenesis pathophysiology Protein required SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2‐infected secretion suggested susceptibility therapeutic intervention triggered [DOI] 10.1111/apha.13733 PMC 바로가기 [Article Type] Review Article
ACE2 function in the pancreatic islet: Implications for relationship between SARS‐CoV‐2 and diabetesReview Article Published on 2021-10-022022-10-27 Journal: Acta physiologica (Oxford, England) [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] ACE2 addition angiotensin‐converting enzyme 2 Beta cells Cell cell physiology cells COVID‐19 patient COVID‐19 diabete diabetes dissect Effect Endocrine enzyme expressed expression Factor Glucose glucose homoeostasis homoeostasis host cells in vitro infect Injury insulin Insulin sensitivity islet islets lung metabolism molecular molecular mechanism pancrea pancreatic pancreatic islet Pathogenesis pathophysiology Protein required SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2‐infected secretion suggested susceptibility therapeutic intervention triggered [DOI] 10.1111/apha.13733 PMC 바로가기 [Article Type] Review Article
Key Considerations for the Development of Safe and Effective SARS‐CoV‐2 Subunit Vaccine: A Peptide‐Based Vaccine Alternative안전하고 효과적인 SARS -COV -2 서브 유닛 백신 개발을위한 주요 고려 사항 : 펩티드 기반 백신 대안Review Published on 2021-06-272022-09-01 Journal: Advanced Science [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] angiotensin‐converting enzyme 2 antibody‐dependent enhancement Antigen antigens B‐cell clinical symptom conserved COVID‐19 critical binding residues deleted development developmental disorder Economy effective effective vaccine Effective vaccines Epitopes exhibit focus genetic material global health Health immune response immune responses immunogenic immunopathological Infection mechanisms mutant Neutralizing Neutralizing antibodies nonstructural protein peptide peptide vaccine Peptide vaccines Protective protective role Protein Proteins Receptor binding domain Safe SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 similarities similarity Spike protein T‐cell type‐I interferons Vaccine vaccine antigen Vaccines Viral Viral protein Viral proteins virus [DOI] 10.1002/advs.202100985 PMC 바로가기 [Article Type] Review
Molecular PET/CT Profiling of ACE2 Expression In Vivo: Implications for Infection and Outcome from SARS‐CoV‐2생체 내에서 ACE2 발현의 분자 PET/CT 프로파일 링 : SARS -COV -2의 감염 및 결과에 대한 시사점Research Article Published on 2021-06-262022-09-01 Journal: Advanced Science [Category] MERS, SARS, 진단, [키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin‐converting enzyme 2 animal model approach binding causative agent clinical evaluation coronavirus disease Coronavirus disease 2019 COVID‐19 Critical determine disease entry receptor enzyme evaluated facilitate healthy volunteer healthy volunteers high affinity Human identify impacted IMPROVE in vitro infect cell infect cells infection process key factor model systems molecular molecular imaging MONITOR organ organs Patient peptide PET/CT positron emission Positron emission tomography positron emission tomography imaging Profiling provide Quantitative quantitative determination question radiolabeled Rapid receptor reported reproductive reproductive system Research respiratory SARS‐CoV‐2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus‐2 severity subject susceptible the patient tissue tomography translational Translational research unique whole body [DOI] 10.1002/advs.202100965 PMC 바로가기 [Article Type] Research Article
The role and significance of angiotensin‐converting enzyme 2 peptides in the treatment of coronavirus disease 2019코로나바이러스 질환 치료에서 안지오텐신 전환 효소 2 펩티드의 역할과 중요성 2019Review Published on 2021-05-052022-09-10 Journal: Journal of Clinical Laboratory Analysis [Category] MERS, SARS, 치료제, [키워드] ACE2 ACE2 protein acute respiratory distress syndrome Amino acid amino acids angiotensin angiotensin‐converting enzyme 2 binding binding ability caused coronavirus disease Coronavirus disease 2019 COVID‐19 drug Drug development drug prediction enzyme Health Infection information involved lead life lysine Mutation Novel coronavirus optimization peptide peptides Prevent Region Regulation Stress treat Treatment [DOI] 10.1002/jcla.23789 PMC 바로가기 [Article Type] Review
Alternative antibiotic feed additives alleviate pneumonia with inhibiting ACE‐2 expression in the respiratory system of pigletsOriginal Research Published on 2020-12-272022-10-31 Journal: Food Science & Nutrition [Category] COVID-19, [키워드] accompanied ACE ACE inhibitor addition allergies allergy alleviate alternative antibiotic angiotensin‐converting enzyme 2 antibiotic Antibiotics decrease develop enzyme expression Extract feed additive Granule growth Immunoglobulin immunoglobulin A incidence inhibiting inhibitor intestinal lower expression lung tissue mechanism of action Piglets Pneumonia PROTECT reduce expression reducing reported respiratory symptom Respiratory system risk Schematic selected serum immunoglobulin level Side effect significantly significantly lower tracheal Treatment weaning [DOI] 10.1002/fsn3.2089 PMC 바로가기 [Article Type] Original Research
A Hydrophobic‐Interaction‐Based Mechanism Triggers Docking between the SARS‐CoV‐2 Spike and Angiotensin‐Converting Enzyme 2Full Paper Published on 2020-10-152022-10-31 Journal: Global Challenges [Category] COVID-19, [키워드] ACE2 ACE2 protein acute respiratory syndrome angiotensin‐converting enzyme 2 antibody blockers cellular receptor chain structure coronavirus coronavirus disease COVID‐19 COVID‐19 docking Effect enzyme greater hydrophilic hydrophobic hydrophobic interactions Interaction involved mechanism pandemic physical Protein RBD receptor‐binding domain responsible reveal SARS‐CoV‐2 SARS‐CoV‐2 spike SARS‐CoV‐2 shielding significantly Taking tension the binding affinity therapeutic Trigger understanding Vaccines water molecules [DOI] 10.1002/gch2.202000067 PMC 바로가기 [Article Type] Full Paper
Expression of ACE2 in airways: Implication for COVID‐19 risk and disease management in patients with chronic inflammatory respiratory diseasesArticle Published on 2020-10-062023-06-15 Journal: Clinical and experimental allergy : journal of the [Category] MERS, SARS, [키워드] airway disease angiotensin‐converting enzyme 2 Coronavirus disease 2019 management severe acute respiratory syndrome coronavirus 2 [DOI] 10.1111/cea.13746 PMC 바로가기
Could Anti‐Hypertensive Drug Therapy Affect the Clinical Prognosis of Hypertensive Patients With COVID‐19 Infection? Data From Centers of Southern ItalyArticle Published on 2020-08-172023-07-02 Journal: Journal of the American Heart Association [Category] SARS, [키워드] angiotensin‐converting enzyme 2 anti‐hypertensive drugs cardiovascular disease COVID‐19 Epidemiology hypertension [DOI] 10.1161/JAHA.120.016948 PMC 바로가기
Genetic variability of human angiotensin‐converting enzyme 2 (hACE2) among various ethnic populationsOriginal Article Published on 2020-06-182022-10-30 Journal: Molecular Genetics & Genomic Medicine [Category] COVID-19, MERS, SARS, [키워드] absence ACE gene ACE2 Affect allele frequency angiotensin angiotensin‐converting enzyme 2 appear Asian Asians binding binding free energy calculated Caucasians cellular entry changes in Characteristics Chinese clinical impact COVID‐19 COVID‐19 death demonstrated eight enzyme ethnic variation European examined explain expression expression level Factor functional Gene Expression Generalizability genetic difference Genetic polymorphism genetics hACE2 hACE2 receptor human populations implication in vitro Infection infections influence magnitude minor allele frequency Missense mutation Molecular dynamics simulation Mortality mutant Mutation Numerous paucity of data performed polymorphism Population Potential treatment Protein receptor Result S protein SARS‐CoV‐2 SARS‐CoV‐2 severity susceptibility target Variability variant Variation virus [DOI] 10.1002/mgg3.1344 PMC 바로가기 [Article Type] Original Article