Effect of mutation on structure, function and dynamics of receptor binding domain of human SARS-CoV-2 with host cell receptor ACE2: a molecular dynamics simulations study돌연변이가 숙주 세포 수용체 ACE2와 인간 SARS-CoV-2의 수용체 결합 도메인의 구조, 기능 및 역학에 미치는 영향: 분자 역학 시뮬레이션 연구Article Published on 2021-11-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 변종, [키워드] 6M0J ACE2 ACE2-RBD Affect Alanine alanine mutant alanine mutants Analysis angiotensin angiotensin-converting enzyme-II binding binding affinity cellular protease cellular proteases complex complexes conserved coronavirus Critical Directed mutagenesis disease severity drug Effect entry of SARS-CoV-2 enzyme exhibit FIVE flexible host cell host cell receptor human ACE2 human SARS-CoV-2 hydrogen Infection information inhibitor initiate Interface residues intermolecular hydrogen bond MD simulation MD simulations molecular molecular dynamics Molecular dynamics simulation molecular interaction motif Mutagenesis mutant Mutation priming Principal component provide RBD RBM recent Receptor binding Receptor binding domain receptor binding motif receptor binding motif. Receptor-binding domain Replication rate residue residues SARS-CoV SARS-CoV-2 SARS-CoV-2 RBD Spike protein supported the binding affinity the receptor-binding domain viral spike protein ward wild-type [DOI] 10.1080/07391102.2020.1802348 PMC 바로가기 [Article Type] Article