Harnessing Natural Products by a Pharmacophore-Oriented Semisynthesis Approach for the Discovery of Potential Anti-SARS-CoV-2 Agents잠재적인 Anti-SARS-CoV-2 제제의 발견을 위한 약동학 지향 반합성 접근법에 의한 천연물 활용Article Published on 2022-07-112022-09-11 Journal: Angewandte Chemie (International ed. in English) [Category] COVID19(2023년), SARS, 치료제, [키워드] agent anti-SARS-CoV-2 Anti-SARS-CoV-2 Agents antiviral activity applied approach assembly cascade Cell complex structure creation Domino Reactions EpiC HPA inhibited mechanism natural natural products oridonin pharmacophore Potential product Rearrangement Remdesivir SARS-CoV-2 replication Semisynthesis suggested unique Wolff Wolff Rearrangement. [DOI] 10.1002/anie.202201684 PMC 바로가기 [Article Type] Article
Molnupiravir for the treatment of COVID-19Article Published on 2022-07-012023-07-10 Journal: Drugs of today (Barcelona, Spain : 1998) [Category] COVID19(2023년), [키워드] Anti-SARS-CoV-2 Agents antiviral drugs COVID-19 molnupiravir Nucleoside analogues RNA-dependent RNA polymerase (RdRp) inhibitors Viral replication inhibitors. [DOI] 10.1358/dot.2022.58.7.3419558
Flavonoid compounds of buah merah ( Pandanus conoideus Lamk) as a potent SARS-CoV-2 main protease inhibitor: in silico approachResearch Published on 2021-08-102022-10-31 Journal: Future Journal of Pharmaceutical Sciences [Category] COVID-19, [키워드] absorbed anti-SARS-CoV-2 Anti-SARS-CoV-2 Agents antiparasitic Antiviral antiviral drug AutoDock binding affinity can be used Candidates carotenoid carried complex complexes Compound COVID-19 COVID19 determine docking result effective examined flavonoid fraction global pandemic in silico Approach Indonesia ingredient inhibitor Interaction Ligand metabolite Pandanus conoideus PDB ID pharmacokinetic protease quercetin Quercetin 3-O-glucose Quercetin 3′-glucoside receptor Result SARS-CoV-2 main protease stability Taxifolin 3-O-α-arabinopyranose the SARS-CoV-2 Toxicity [DOI] 10.1186/s43094-021-00309-0 PMC 바로가기 [Article Type] Research
Overview of therapeutic drug research for COVID-19 in ChinaReview Article Published on 2020-06-172023-07-01 Journal: Acta pharmacologica Sinica [Category] SARS, [키워드] Anti-SARS-CoV-2 Agents COVID-19 Favipiravir Hydroxychloroquine novel coronavirus pneumonia SARS-CoV-2 therapeutic drugs Traditional Chinese medicine [DOI] 10.1038/s41401-020-0438-y PMC 바로가기 [Article Type] Review Article