In silico analysis of SARS-CoV-2 spike protein N501Y and N501T mutation effects on human ACE2 bindingSARS-CoV-2 스파이크 단백질 N501Y 및 N501T 돌연변이가 인간 ACE2 결합에 미치는 영향에 대한 실리코 분석Article Published on 2022-11-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis analyzed anti-SARS-CoV-2 antibodies Anti-viral drugs antisense attachment binding binding energy binding free energy classic Dynamics Effect Effect of mutations on binding energy effective free energy hACE2 hACE2 receptor hACE2-SARS-CoV-2 spike protein binding. handling highlight Host human ACE2 maintain molecular molecular dynamics molecular dynamics simulations Mutation N501Y N501Y and N501T mutations nine outcome predicted Protein binding raised Replication SARS CoV SARS-CoV-2 SARS-CoV-2 mutations SARS-CoV-2 spike protein Spike protein survival Transmissibility treatment strategy Vaccines virus [DOI] 10.1016/j.jmgm.2022.108260 PMC 바로가기 [Article Type] Article
Comprehensive fitness landscape of SARS-CoV-2 M pro reveals insights into viral resistance mechanismsSARS-CoV-2 M pro의 종합적인 피트니스 환경은 바이러스 저항 메커니즘에 대한 통찰력을 보여줍니다Article Published on 2022-06-202022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition Amino acid amino acid changes amino acids analyzed Anti-viral drugs can be used cleave Complete Comprehensive conserved contribute Coronavirus-2 correlated Critical deep mutational scanning deep sequencing defined drug drug design drug resistance Effect effective elicit evade Evolution Evolutionary biology expression functional human population Infectious disease inhibitor inhibitors life cycle M pro main protease mechanism Microbiology MPro Mutation network new strain performed physically protease Protein reduced reveal S. cerevisiae SARS-CoV-2 SARS-CoV-2 main protease selection pressure Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Toxicity Vaccines variant viral life cycle Viral resistance virulent yeast [DOI] 10.7554/eLife.77433 PMC 바로가기 [Article Type] Article
Combination of QSAR, molecular docking, molecular dynamic simulation and MM-PBSA: analogues of lopinavir and favipiravir as potential drug candidates against COVID-19QSAR, 분자 도킹, 분자 동적 시뮬레이션 및 MM-PBSA의 조합: COVID-19에 대한 잠재적 약물 후보로서 로피나비르 및 파비피라비르의 유사체Article Published on 2022-05-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제, [키워드] Absorption active site analogue Analysis anti-viral drug Anti-viral drugs binding affinity candidate Candidates Compound COVID-19 COVID-19 infection COVID-19 infections demonstrated disease distribution docked complex docking drug candidate druggability effective enzyme Enzymes Favipiravir feature form identify IMPROVE in vitro inhibit Interaction less Lopinavir M pro metabolism Modification molecular molecular docking molecular dynamic simulations molecular dynamics Molecular dynamics simulation novel drug physicochemical polyprotein polyproteins processing protease QSAR Quantitative RdRP Replication residue RNA RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 selected shown significantly small molecule Small molecules Spread stable complex Toxicity trajectory translated Treatment Viral RNA viral RNA-dependent RNA polymerase [DOI] 10.1080/07391102.2020.1850355 PMC 바로가기 [Article Type] Article
Inflawell ® improves neutrophil-to-lymphocyte ratio and shortens hospitalization in patients with moderate COVID-19, in a randomized double-blind placebo-controlled clinical trialInflawell®은 무작위 이중 맹검 위약 대조 임상 시험에서 중등도 COVID-19 환자의 호중구 대 림프구 비율을 개선하고 입원 기간을 단축합니다.Randomized Controlled Trial Published on 2022-04-012022-09-11 Journal: Inflammopharmacology [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] activated activities addition administration Anti-inflammatory Anti-viral drugs average baseline Boswellia boswellic acids clinical clinical symptom Clinical symptoms clinical trial completion conducted cough COVID-19 COVID-19 symptom COVID-19 symptoms CRP Cytokines Disease progression double-blind duration of hospitalization dysfunction Dyspnea dysregulated immune response enrolled evaluated Fewer patients Gustatory headache help Hospital stay Hospitalization hospitalized patient IMPROVE increase in Inflammation Inflawell® syrup Intervention investigated LDH lymphocyte Lymphocytes marker Moderate COVID-19 moderate COVID-19 patients myalgia neutrophil Neutrophil-to-lymphocyte ratio Neutrophils NLR NLR. olfactory olfactory and gustatory dysfunction oxygen oxygen saturation Patient patients with moderate PCR-positive Placebo placebo group placebo-controlled placebo-controlled clinical trial Prevent prevent disease progression pro-inflammatory cytokines public health Randomized reduce Registered significant decrease significant increase significantly shorter Standard of care statistically significant Symptom syrup the placebo group the WHO therapeutic potential TNF Treatment Trial unique Vaccine [DOI] 10.1007/s10787-022-00928-w PMC 바로가기 [Article Type] Randomized Controlled Trial
Identification of potent small molecule inhibitors of SARS-CoV-2 entrySARS-CoV-2 진입의 강력한 소분자 억제제의 식별Article Published on 2022-01-012022-09-11 Journal: SLAS discovery : advancing life sciences R & D [Category] SARS, 변종, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin angiotensin-converting enzyme 2 Anti-viral drugs assays Cell cellular receptor characterized coronavirus COVID-19 Effectiveness high affinity highlighting HTS identification Immunocompromised infectivity assays inhibitor Interaction molecular docking Mutation novel protease responsible reveal robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 protease SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus small molecule small molecule inhibitor Small molecule inhibitors specific inhibitor Spike protein target cells the spike protein the vaccine Transmissibility unique variants variants of SARS-CoV-2 viral spike protein virus entry [DOI] 10.1016/j.slasd.2021.10.012 PMC 바로가기 [Article Type] Article
An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection기도 오르가노이드 기반 스크린은 SARS-CoV-2 감염에서 HIF1α-해당 축의 역할을 식별합니다Article Published on 2021-10-152022-09-11 Journal: Cell Reports [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] 2-furoic acid Abstract acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 airway airway organoid Alpha Analysis Anti-viral drugs B.1.351 block cells Chemical Compound coronavirus develop Disease model disease models dissect fatty Fatty acid fatty acid synthesis Genetic Glycolysis GW4671 high content drug screen hPSC-derived colonic organoid hPSC-derived colonic organoids human airway Human airway epithelium hypoxia hypoxia-inducible factor 1-alpha identify Infection inhibiting inhibitor mechanism metabolic MONITOR Organoid platform pluripotent stem cell respiratory reveal RNA sequencing RNA-Seq SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant Screen severe acute respiratory syndrome Coronavirus stem cells subunit suppress Transcriptome Treatment xanthohumol [DOI] 10.1016/j.celrep.2021.109920 PMC 바로가기 [Article Type] Article
Comparative molecular investigation of the potential inhibitors against SARS-CoV-2 main protease: a molecular docking studyComparative Study Published on 2021-10-012022-10-04 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, [키워드] Anti-viral Anti-viral drugs Assessing binding affinity Comparative complex COVID-19 docked drug drug candidate Drug discovery effective epirubicin Escalation Evidence exhibited filtered In-vitro indicated inhibit inhibitor inhibitors Interaction less literature review molecular molecular docking molecular docking studies Molecular dynamics simulation Novel coronavirus outbreak pandemic pathogen recent reduce mortality saquinavir SARS-CoV-2 SARS-CoV-2 virus synergistic Vaccine vapreotida. [DOI] 10.1080/07391102.2020.1796813 PMC 바로가기 [Article Type] Comparative Study
SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte eliminationSARS-CoV-2 스파이크 단백질은 합포체 매개 림프구 제거를 지시합니다Article Published on 2021-09-012022-09-11 Journal: Cell Death and Differentiation [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-viral drug Anti-viral drugs cause cells cellular cellular structure contagious coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 therapy death expression identify induce inhibit lung tissue lung tissues lymphocyte Lymphocytes lymphocytopenia mechanism membrane fusion molecular motif patients polybasic prevalent respiratory S1/S2 cleavage site SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus spike glycoprotein Structure structures Surface glycoprotein Syncytia syncytium target the SARS-CoV-2 therapy unique virus viruses [DOI] 10.1038/s41418-021-00782-3 PMC 바로가기 [Article Type] Article
Potential inhibitors of the main protease of SARS-CoV-2 and modulators of arachidonic acid pathway: Non-steroidal anti-inflammatory drugs against COVID-19SARS-CoV-2의 주요 프로테아제 및 아라키돈산 경로 조절제의 잠재적 억제제: COVID-19에 대한 비스테로이드성 항염증제Article Published on 2021-09-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 신약개발, 치료제, [키워드] 3CLpro anti-inflammatory drug anti-viral drug Anti-viral drugs antiviral drugs arachidonic acid Arachidonic acid pathway attenuate AutoDock AutoDock vina binding affinities binding affinity Candidates chymotrypsin Chymotrypsin-like protease Compound conducted COVID-19 Cytokine storm dataset develop Disturbed docking docking result docking results downregulation evaluated Final Gene expression profiling hepatotoxicity highlight inflammatory mediator Inflammatory mediators inhibitor inhibitor N3 Interaction investigated Ligand lower binding energy metabolic molecular molecular docking Molecular simulation NCBI GEO non-steroidal anti-inflammatory drug Non-steroidal anti-inflammatory drugs NSAID NSAIDS pathway performed perturbations Potential predicted protease Repository SARS-CoV-2 SARS-CoV2 selected Systems biology Talniflumate target the cytokine storm the SARS-CoV-2 Z-score [DOI] 10.1016/j.compbiomed.2021.104686 PMC 바로가기 [Article Type] Article
Antibody Responses and the Effects of Clinical Drugs in COVID-19 PatientsCOVID-19 환자에서 항체 반응과 임상 약물의 효과Immunology Published on 2021-06-092022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, [키워드] Affiliated Hospital Anti-RBD IgG anti-viral drug Anti-viral drugs antibody Antibody titer Arbidol Bilirubin Chloroquine clinical Clinical treatment collected coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CRP demonstrated diagnosed direct bilirubin disease drug Effect ELISA Epidemic epidemic disease glucocorticoid Host humoral Humoral response humoral responses hydroxybutyrate dehydrogenase IgG and IgM IgM antibodies Infection Inflammatory responses laboratory-confirmed Laboratory-confirmed COVID-19 Lactate lactate dehydrogenase LDH Lopinavir Lopinavir/ritonavir lymphocyte Patient peripheral lymphocyte plasma plasma sample plasma samples Protein Protein subunit RBD Receptor binding domain reduced response Ritonavir SARS-CoV-2 SARS-CoV-2 nucleic acid serum severe symptom severe symptoms significantly Specific specific antibodies specific antibody Spike protein subunit suggested Sun Yat-sen therapy total bilirubin university while α-Hydroxybutyrate dehydrogenase [DOI] 10.3389/fimmu.2021.580989 PMC 바로가기 [Article Type] Immunology