Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infectionArticle Published on 2023-11-212024-09-05 Journal: Cell Reports Medicine [Category] update2024, [키워드] antibody cocktail cryo-EM Epstein-Barr virus gHgL-gp42 complex Neutralizing antibodies [DOI] 10.1016/j.xcrm.2023.101296 PMC 바로가기 [Article Type] Article
Evaluation of a panel of therapeutic antibody clinical candidates for efficacy against SARS-CoV-2 in Syrian hamstersArticle Published on 2023-03-302024-09-05 Journal: Antiviral research [Category] update2024, [키워드] animal model antibody cocktail COVID-19 monoclonal antibody SARS-CoV-2 Therapeutic antibody [DOI] 10.1016/j.antiviral.2023.105589 PMC 바로가기 [Article Type] Article
A novel plant-made monoclonal antibody enhances the synergetic potency of an antibody cocktail against the SARS-CoV-2 Omicron variantArticle Published on 2023-03-012023-07-10 Journal: Plant Biotechnology Journal [Category] COVID19(2023년), [키워드] antibody cocktail COVID-19 monoclonal antibody (mAb) Neutralization synergy plant-made antibody variants of concern [DOI] 10.1111/pbi.13970 PMC 바로가기
DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2Article Published on 2022-10-062022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] administration animal challenge model antibodies antibody cocktail Antigen antiviral potency binding cryo-EM demonstrated Efficacy effort exhibit forms functional High-resolution in vivo Interaction lineages mAb monoclonal antibody monoclonal antibody therapy omicron performed populations promote Prophylactic Prophylaxis Protective Protein SARS-CoV-2 serum antibody specificity Strategy Support trimeric [DOI] 10.1038/s41467-022-33309-6 PMC 바로가기
Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadthArticle Published on 2022-09-222022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, [키워드] activity antibodies antibody antibody cocktail antibody resistance binding breadth computational simulation costly COVID-19 crosslinking cryo-EM Engineering epitope exhibit IMPROVE Infection mouse model Neutralizing Neutralizing activity parental RBD reduce SARS-CoV-2 SARS-CoV-2 variant the receptor-binding domain therapeutic efficacy therapy variants virus-neutralizing X-ray crystallography [DOI] 10.1038/s41467-022-33284-y PMC 바로가기
Preclinical characterization of amubarvimab and romlusevimab, a pair of non-competing neutralizing monoclonal antibody cocktail, against SARS-CoV-2Article Published on 2022-09-142022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome amino acid substitution amubarvimab (BRII-196) antibody antibody cocktail Clinical efficacy Combination controls coronavirus coronavirus disease COVID-19 demonstrated Emergency use authorization epitope EUA Evolution half-maximal inhibitory concentration half-maximal inhibitory concentration (IC50) in vitro introduced less Lung pathology Lungs M252Y/S254T/T256E (YTE) mAb mAbs Modification monoclonal antibody monoclonal antibody (mAb) Mutation neutralize neutralized Neutralizing Post-infection Preclinical RBD receiving Receptor binding domain receptor binding domain (RBD) reduce reduced regions regulatory authority resulting retained romlusevimab (BRII-198) SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants serum severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significantly Spike protein Support susceptibility therapeutic option variant variant of concern (VOC) variants variants of concern Viral load virus VoC weight loss [DOI] 10.3389/fimmu.2022.980435 PMC 바로가기
A counterintuitive antibody cocktail disrupts coxsackievirusArticle Published on 2022-09-142022-11-15 Journal: Cell Host & Microbe [Category] Fulltext, MERS, 진단, [키워드] accelerated antibody cocktail COVID-19 pandemic coxsackievirus disrupt function Infectious disease monoclonal antibody Prevent therapeutic treat virions [DOI] 10.1016/j.chom.2022.08.010 PMC 바로가기
IMM-BCP-01, a patient-derived anti-SARS-CoV-2 antibody cocktail, is active across variants of concern including Omicron BA.1 and BA.2Article Published on 2022-09-092022-11-15 Journal: Science Immunology [Category] SARS, 변종, 진단, [키워드] ACE2 receptor Activation acute respiratory syndrome ADCC anti-SARS-CoV-2 antibody antibodies antibody antibody cocktail Antiviral antiviral activity binding blocked Cell Complement pathway convalescent coronavirus COVID-19 Delta demonstrated Efficacy epitope in vitro in vivo Infection lung memory B Neutralizing neutralizing antibody omicron Patient phagocytosis preclinical data Protein RBD SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant spike susceptible individuals Syrian golden hamster tested the SARS-CoV-2 the Spike Therapies therapy variants of concern Viral mutagenesis [DOI] 10.1126/sciimmunol.abl9943 PMC 바로가기
Clinical efficacy of casirivimab-imdevimab antibody combination treatment in patients with COVID-19 Delta variant코로나19 델타 변이형 환자에서 카시리비맙-임데비맙 항체 병용요법의 임상적 효능Article Published on 2022-09-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), SARS, 변종, 임상, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus 2 administration age antibody cocktail antibody combination antibody treatment Casirivimab Casirivimab-imdevimab treatment clinical Clinical efficacy cocktail Combination conducted control group coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient death Delta delta variant dose Efficacy evaluate FIVE High flow nasal cannula high-risk patient High-risk patients hospital Hospitalization Imdevimab inclusion criteria intravenously Japan mechanical ventilation monoclonal antibodies monoclonal antibody nasal nasal cannula Neutralizing antibodies outcome oxygen Oxygen therapy Patient patients with COVID-19 receive reduce reduced respiratory risk SARS-CoV-2 significantly lower therapy Treatment treatment group Viral Viral load with COVID-19 [DOI] 10.1016/j.jiac.2022.05.012 PMC 바로가기 [Article Type] Article
Safety of casirivimab/imdevimab administration in a SARS-CoV-2 positive maintenance dialysis patient in Japan일본에서 SARS-CoV-2 양성 유지 투석 환자에서 카시리비맙/임데비맙 투여의 안전성Article Published on 2022-08-012022-09-12 Journal: CEN case reports [Category] SARS, 진단, [키워드] abnormal immune response Administered administration antibody cocktail approved Baricitinib casirivimab/imdevimab controlling coronavirus disease COVID-19 cytokine secretion dialysis Diseases Healthcare system Hemodialysis high risk Inflammation infusion Japan monoclonal antibody Neutralizing Patient patients with COVID-19 positive reaction receiving REGEN-COV Remdesivir Safe Safety SARS-CoV-2 severe disease supplemental oxygen therapeutic strategy therapy Treatment [DOI] 10.1007/s13730-021-00671-1 PMC 바로가기 [Article Type] Article