The long-term dynamics of serum antibodies against SARS-CoV-2Article Published on 2022-12-152023-07-11 Journal: PeerJ [Category] COVID19(2023년), [키워드] age antibody production COVID-19 patients Gender immune responses S-UFRJ SARS-CoV-2-specific antibodies Seroconversion Serologic response spike glycoprotein [DOI] 10.7717/peerj.14547 PMC 바로가기
Association between SARS-CoV-2 infection and de novo HLA donor specific antibody production in lung transplant recipients: Single-center studyArticle Published on 2022-11-012022-11-15 Journal: Human immunology [Category] SARS, 진단, 치료기술, [키워드] antibody antibody production association COVID-19 COVID-19 pandemic de novo diagnosed with COVID-19 Diagnosis Donor donor specific antibodies HLA HLA antibodies HLA class I incidence include Infection LTR lung transplant MFI morbidity and mortality no significant difference outcome performed raised recipient recipients respiratory retrospective SARS-COV-2 infection the median viral infection [DOI] 10.1016/j.humimm.2022.07.007 PMC 바로가기
Single-cell transcriptomic atlas reveals distinct immunological responses between COVID-19 vaccine and natural SARS-CoV-2 infectionArticle Published on 2022-11-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Activation acute respiratory syndrome alteration Analysis antibody production Apoptosis B cell caused collected CoronaVac coronavirus COVID-19 COVID-19 infected patient COVID-19 patients COVID-19 vaccine cytotoxicity downregulation Emergency use authorization expression expression of gene feature greater HLA class II IL21R immune Immune cell immune cell types immune response immunization immunized immunological Immunological response immunological responses inactivated Inactivated vaccine individual individuals Infection Inflammatory cytokine innate immune cell interferon response magnitude mechanism Migration mononuclear cells naïve B cell naïve B cells pandemic PBMC Peripheral blood phenotype plasma profile Proinflammatory cytokine proportion provide reveal SARS-CoV-2 SARS-COV-2 infection scRNA-seq Sequencing severe disease single-cell Single-cell RNA sequencing single-cell sequencing Sinovac systemic immune response T cell thrombosis transcriptomic upregulation vaccine-induced immune response [DOI] 10.1002/jmv.28012 PMC 바로가기
Evaluation of the systemic and mucosal immune response induced by COVID-19 and the BNT162b2 mRNA vaccine for SARS-CoV-2Article Published on 2022-10-182022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] antibody antibody production appear BNT162b2 BNT162b2 mRNA vaccine convalescent correlated COVID-19 COVID-19 patients decrease detectable eight elicit functional generate Heterologous humoral humoral immune response Immunity immunization increase induce marker mRNA vaccination mRNA vaccine mucosal mucosal immune NAb Neutralizing neutralizing capacity of BNT162b2 omicron peaked progression proportion protective immune response RBD RBD-binding antibody reduced Saliva SARS-CoV-2 second dose second vaccination sera significantly Spike protein subsequent the RBD the S1 subunit the SARS-CoV-2 vaccinated individual vaccination Vaccine vaccinee vaccinees variant virus neutralizing titers VoC VOCs wildtype [DOI] 10.1371/journal.pone.0263861 PMC 바로가기
Assessing T-Cell Immunity in Kidney Transplant Recipients with Absent Antibody Production after a 3rd Dose of the mRNA-1273 VaccineArticle Published on 2022-10-152022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 진단, [키워드] addition age analyzed antibody production Assessing association CD19+ CD3+ CD4+ CD8+ Cell-mediated immunity Cellular immune response Cohort complement Concentration COVID-19 COVID-19 vaccines dose effective Gender highlight humoral Humoral immunity IFN-γ immune independent variable interferon-gamma release assay kidney kidney transplant recipient Kidney transplantation Linear regression analysis lymphocyte mRNA-1273 mRNA-1273 vaccine patients positive Production recipient Responder SARS-CoV-2 SD Biosensor seronegative patient statistically significant Surveillance T cell response T cells tested Transplant [DOI] 10.3390/ijms232012333 PMC 바로가기
Social connection and gene regulation during the COVID-19 pandemic: Divergent patterns for online and in-person interactionArticle Published on 2022-10-012022-11-15 Journal: Psychoneuroendocrinology [Category] 치료제, [키워드] absence analyzed antibody production antiviral immunity antiviral response association blood sample characterized connection conserved COVID-19 COVID-19 pandemic CTRA disease risk down-regulation Effect eudaimonia examined experience Factors female Gene Expression Health healthy Immune cell immune system Interaction Linear model loneliness measure Multiple offset Online social interaction profile proinflammatory gene quantified question reduced Regulation RNA Social genomics. social interaction transcriptional response [DOI] 10.1016/j.psyneuen.2022.105885 PMC 바로가기
A Glycosylated RBD Protein Induces Enhanced Neutralizing Antibodies against Omicron and Other Variants with Improved Protection against SARS-CoV-2 InfectionArticle Published on 2022-09-142022-11-15 Journal: Journal of Virology [Category] SARS, 변종, 진단, [키워드] Affect antibody production B.1.1.529 B.1.1.7 lineage B.1.351 B.1.427 B.1.429 B.1.617.2 Beta coronavirus COVID-19 COVID-19 vaccine Delta delta variant demonstrated develop disease severity domain effective effective vaccine Effectiveness Efficacy elicited enhanced enhanced protection epitope Epsilon Gamma global public health highlight human ACE2 immunized immunized mice immunodominant IMPROVE Improved improved neutralizing activity induce Lineage mice mutant mutated Mutation Neutralizing Neutralizing activity neutralizing antibody Neutralizing antibody titer Numerous omicron Omicron and other variants Other P.1 pandemic Prevent probe protection Protective Protein pseudotyped pseudovirus RBD RBD protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants shown significantly Strains subunit Subunit vaccine the receptor-binding domain threat Transmissibility Vaccine variant variants weight loss [DOI] 10.1128/jvi.00118-22 PMC 바로가기
Dynamics of anti-SARS-CoV-2 seroconversion in individual patients and at the population levelArticle Published on 2022-09-092022-11-15 Journal: PLoS ONE [Category] SARS, 진단, 치료기술, 치료제, [키워드] anti-SARS-CoV-2 anti-SARS-CoV-2 IgG antibody antibody production Asymptomatic Care COVID-19 demonstrated determine diagnosed Dynamics fraction Health hidden highest highlighting immune response Immunity individual infected with SARS-CoV-2 Infection key factor levels of antibodies Mild observation occurred pandemic Pandemics participant Patient Perspective Poland population level Population screening positive predict Registered SARS-CoV-2 SARS-COV-2 infection Seroconversion specific antibody suppress Trajectories Vaccinations [DOI] 10.1371/journal.pone.0274095 PMC 바로가기
Utility of in silico-identified-peptides in spike-S1 domain and nucleocapsid of SARS-CoV-2 for antibody detection in COVID-19 patients and antibody productionArticle Published on 2022-09-052022-11-15 Journal: Scientific Reports [Category] SARS, 변종, 진단, 치료기술, [키워드] 2D structure 3D structure analyzed antibody Antibody detection antibody production Antibody Response Antigen antigenic peptides changes in COVID-19 patient COVID-19 patients domain eight Evidence homology immunogenic in silico analysis limitation N protein New nucleocapsid peptide performed Proteins provide RBD Result S1 domain SARS-CoV-2 SARS-CoV-2 variant selected sequence serum serum sample Seven Standardization structural proteins the N protein the spike protein trimer virus viruses were used [DOI] 10.1038/s41598-022-18517-w PMC 바로가기
Single-cell analysis of the adaptive immune response to SARS-CoV-2 infection and vaccinationArticle Published on 2022-09-022022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] adaptive Adaptive immune response adaptive immune responses addition antibody antibody production B cells B-cell BCR component COVID-19 Critical develop effective flow cytometry immune immune protection immune response Infection Measures molecular mechanism natural infection offer pandemic Pathogenesis Protective recent receptor SARS-CoV-2 SARS-COV-2 infection severity single-cell single-cell analysis Support T cell T-cell receptor TCR the disease therapeutic intervention transcriptomics vaccination Vaccine variants [DOI] 10.3389/fimmu.2022.964976 PMC 바로가기