Serum antibody fingerprinting of SARS-CoV-2 variants in infected and vaccinated subjects by label-free microarray biosensorImmunology Original Research Published on 2024-02-272024-09-05 Journal: Frontiers in immunology [Category] update2024, [키워드] antibody repertoire IgA immunoglobulins Label-free biosensor rapid detection reflective phantom interface Serological assay wash-free assay [DOI] 10.3389/fimmu.2024.1323406 PMC 바로가기 [Article Type] Immunology Original Research
Obesity Is Associated with an Impaired Baseline Repertoire of Anti-Influenza Virus AntibodiesResearch Article Published on 2023-04-262024-09-05 Journal: Microbiology Spectrum [Category] update2024, [키워드] antibody repertoire influenza vaccines obesity [DOI] 10.1128/spectrum.00010-23 PMC 바로가기 [Article Type] Research Article
Ancestral SARS-CoV-2-Driven Antibody Repertoire Diversity in an Unvaccinated Individual Correlates with Expanded Neutralization Breadtharticle Published on 2023-03-222024-09-05 Journal: Microbiology Spectrum [Category] update2024, [키워드] antibody repertoire Breakthrough infection monoclonal antibodies Neutralizing antibodies omicron SARS-CoV-2 [DOI] 10.1128/spectrum.04332-22 PMC 바로가기 [Article Type] article
Discovery and characterization of SARS-CoV-2 reactive and neutralizing antibodies from humanized CAMouseHG mice through rapid hybridoma screening and high-throughput single-cell V(D)J sequencingArticle Published on 2022-09-232022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome antibodies antibody antibody humanized mice antibody repertoire Antibody Response assays can be used caused Cell clone complementary coronavirus coronavirus disease cynomolgus macaques death deficiency develop diagnostic effective Efficacy evade fully human antibody Genes humanized humans IGHV6-1 immune response immunization immunized Infection Measures medium mice MOST mutate Neutralizing neutralizing antibody pandemic patients with COVID-19 platform produced Prophylactic Protective reactive reactive and neutralizing antibodies Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD binding SARS-CoV-2 virus Sequencing Sequencing analysis significantly single-cell single-cell sequencing the antibody therapeutic variant Virus neutralization [DOI] 10.3389/fimmu.2022.992787 PMC 바로가기
AIRRscape: An interactive tool for exploring B-cell receptor repertoires and antibody responsesArticle Published on 2022-09-202022-11-15 Journal: PLoS Computational Biology [Category] SARS, 진단, [키워드] antibody antibody repertoire Antibody Response antibody sequence B-cell BCR browser CDR3 comparison Coverage dataset dengue virus Exploratory analyses Github HIV-1 Humoral immunity immune Immunoglobulin monoclonal antibody motif Pathogens Patient receptor repertoire responses reveal SARS-CoV-2 selected sequence Sequencing subset Topology Vaccine [DOI] 10.1371/journal.pcbi.1010052 PMC 바로가기
A key F27I substitution within HCDR1 facilitates the rapid maturation of P2C-1F11-like neutralizing antibodies in a SARS-CoV-2-infected donorArticle Published on 2022-09-132022-11-15 Journal: Cell Reports [Category] SARS, 진단, [키워드] Analysis anti-SARS-CoV-2 antibodies antibody antibody repertoire Bioactivity characterized contribute CP: Immunology deep sequencing developmental Donor early infection elicit event facilitate immunogen information Lineage longitudinal maturation monoclonal NAb neutralizing antibody P2C-1F11 lineage pathway reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific antibody sequence significantly viral infection [DOI] 10.1016/j.celrep.2022.111335 PMC 바로가기
Serological responses to human virome define clinical outcomes of Italian patients infected with SARS-CoV-2Article Published on 2022-09-012022-11-15 Journal: International Journal of Biological Sciences [Category] SARS, 치료제, [키워드] acute respiratory syndrome anti-viral antibody antibody repertoire Antibody Response Antiviral Asymptomatic binding Brescia circulating antibody clinical manifestation Clinical outcome Clinical severity coronavirus COVID-19 COVID-19 patient COVID-19 patients COVID-19-related symptom disease severity enrolled epitope geographical region hospitalized patient immune increase in infected with SARS-CoV-2 Italian patient Italy memory B-cell outcome pandemic pathogenic patient survival Pneumonia Predictive respiratory infectious disease response responsible SARS-CoV-2 SARS-COV-2 infection significantly strain to define trajectory unique viral peptide viruses [DOI] 10.7150/ijbs.78002 PMC 바로가기
Template-Based Assembly of Proteomic Short Reads For De Novo Antibody Sequencing and Repertoire ProfilingDe Novo 항체 시퀀싱 및 레퍼토리 프로파일링을 위한 Proteomic Short Read의 템플릿 기반 어셈블리Review Published on 2022-07-262022-09-11 Journal: Analytical Chemistry [Category] MERS, 유전자 메커니즘, 진단, [키워드] Accuracy antibody antibody repertoire antibody sequence antibody sequences antigens assembly B-cells cDNA sequencing complementary dataset de novo disease Fab feature fluids foundation functional Health homologous homologous antibody hypermutation IgG information light chains Liquid chromatography mass mass spectrometry molecular monoclonal antibody offer Patient patients hospitalized polyclonal polyclonal antibodies polyclonal antibody Profiling proteomic provide Read Recombination repertoire secreted sequence Sequencing sera serological assays serum step Stitch Urine with COVID-19 [DOI] 10.1021/acs.analchem.2c01300 PMC 바로가기 [Article Type] Review
Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopesSARS-CoV-2의 중화에는 구조적 수용체 결합 도메인 에피토프에 대한 항체가 필요합니다Article Published on 2022-01-012022-09-11 Journal: Allergy [Category] SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody antibody repertoire Antibody Response Antibody responses clinically conformational conformational epitopes coronavirus correlated COVID-19 Critical determinant determinants domain effective vaccine Effective vaccines epitope Epitopes exposure to humoral immune response IgG IgG antibodies IgG antibody Immunity immunization Immunoglobulin Immunoglobulin G increasingly induce likelihood Mild natural infection Neutralizing antibodies Patient peptide peptide epitope peptide epitopes peptides polyclonal polyclonal antibody Prevent Protective protective immunity RBD RBD binding RBD-specific IgG receptor Receptor-binding domain required respiratory SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2-neutralizing antibodies SARS-CoV-2-neutralizing antibody sera severe acute respiratory syndrome Coronavirus severe COVID-19 Spike protein sterilizing immunity suppression the receptor-binding domain the SARS-CoV-2 vaccination Vaccine Vaccines variant virus Virus neutralization virus variants virus-neutralizing [DOI] 10.1111/all.15066 PMC 바로가기 [Article Type] Article
Analysis of B Cell Receptor Repertoires Reveals Key Signatures of the Systemic B Cell Response after SARS-CoV-2 InfectionB 세포 수용체 레퍼토리 분석, SARS-CoV-2 감염 후 전신 B 세포 반응의 주요 특징 밝혀Vaccines and Antiviral Agents Published on 2021-12-082022-09-12 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Activation Analysis analyzed antibody antibody repertoire Antibody Response Antibody titers B cell B cell receptor B cell response canonical Characteristics characterized clonal expansion clone Cluster collected correlated correlation COVID-19 patients differentiation elicited followed by germ line heavy chain highlighting IgA IgG IgG antibody IGHJ6 IGHV immune response Immunoglobulin individual isotype switching Lineage mAbs massive monoclonal antibodies monoclonal antibody mRNA mRNA transcript mRNA transcripts naïve B cells Neutralizing Peripheral blood peripheral blood samples proportion provided reactive repertoire reported response responses SARS-CoV-2 SARS-COV-2 infection sequence sequenced Sequencing serum antibody serum antibody response shared clonotype signature Somatic hypermutation spike-specific IgG sustained symptom onset systemic transcript transcriptional level Vaccines virus infection [DOI] 10.1128/jvi.01600-21 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents