Plaque-neutralizing antibody to BA.2.12.1, BA.4 and BA.5 in individuals with three doses of BioNTech or CoronaVac vaccines, natural infection and breakthrough infectionArticle Published on 2022-11-012022-11-15 Journal: Journal of Clinical Virology [Category] SARS, 변종, 진단, 치료기술, [키워드] antibody Antibody neutralization Antibody titre B.1.1.529 BNT162b2 booster Breakthrough infection convalescent CoronaVac COVID-19 detectable dose elicited geometric GMT Immune escape individual Infection less natural infection neutralization neutralizing antibody Neutralizing antibody response of BNT162b2 omicron Omicron, Neutralization plaque reduction neutralization PRNT reduction relative SARS-CoV-2 susceptible Transmissibility vaccinated individual vaccination Vaccine Vaccines virus viruses VoC wild- type WT virus [DOI] 10.1016/j.jcv.2022.105273 PMC 바로가기
A multinational, phase 2, randomised, adaptive protocol to evaluate immunogenicity and reactogenicity of different COVID-19 vaccines in adults ≥75 already vaccinated against SARS-CoV-2 (EU-COVAT-1-AGED): a trial conducted within the VACCELERATE networkArticle Published on 2022-10-082022-11-15 Journal: Trials [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ≥75 years. adaptive addition advanced age age Analysis Antibody titre benefit BNT162b2 BNT162b2 (Comirnaty®) booster booster dose changes in Clinical course collected concern conducted COVID-19 COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine dose Endpoint enzyme-linked immunosorbent evaluate exploratory fourth dose humoral immune response immunosenescence include individual initial Intervention mRNA-1273 mRNA-1273 (Spikevax®) multicentre neutralising neutralising antibody titre Older Part Patient performed phase phase II primary endpoint protocol qPCR Quantitative randomisation randomised randomised controlled reactogenicity Research risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine secondary subgroup T cell response the primary endpoint Trial triggered vaccination Vaccine vaccine-induced immune response variants variants of concern VoC wild-type wild-type virus [DOI] 10.1186/s13063-022-06791-y PMC 바로가기
Humoral immunogenicity of COVID-19 vaccines in patients with inflammatory rheumatic diseases under treatment with Rituximab: a case-control study (COVID-19VacRTX)Article Published on 2022-10-062022-11-15 Journal: Rheumatology (Oxford, England) [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Ad26.COV2.S ANCA-associated vasculitis anti-CD20 antibody antibody level Antibody titre approved AZD1222 B cell B-cell B-cells blood sample case-control study CD19+ COVID-19 COVID-19 vaccine dose ELISA evaluated examined Factor first vaccination Frame help humoral humoral immune response immunogenicity Immunoglobulin Improved increased risk Inflammatory International mAb Moderna outcomes parameter Patient quantified RA reduced regimen rheumatic disease rituximab RNA-1273 RTX SARS-CoV-2 severe COVID-19 synchronization the patient therapeutic therapy treated Treatment Univariate analysis vaccination Vaccine [DOI] 10.1093/rheumatology/keac036 PMC 바로가기
Enhanced immune responses following heterologous vaccination with self-amplifying RNA and mRNA COVID-19 vaccinesArticle Published on 2022-10-042022-11-15 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Activation antibody Antibody Response Antibody titre antigen exposure baseline benefit binding BNT162b2 boost CD4+ T cell CD8+ Cellular immune response clinical trial Course COVID-19 Delta dose ELISA ELISPOT enhanced global public health glycoprotein Heterologous highest humoral immune memory immune response immunological increase in individual majority marker median mRNA mRNA COVID-19 vaccine mRNA vaccination mRNA vaccine naïve natural infection neutralising antibody titre omicron participant Participants PCR proportion question receiving recruited response RNA SARS-CoV-2 vaccine second dose seroconverted significantly higher subject the SARS-CoV-2 titre vaccination Vaccination strategy Vaccine variants were measured wildtype [DOI] 10.1371/journal.ppat.1010885 PMC 바로가기
Antibody titers among healthcare workers for coronavirus disease 2019 at 6 months after BNT162b2 vaccinationArticle Published on 2022-09-162022-11-15 Journal: Vaccine [Category] SARS, 진단, [키워드] acute respiratory syndrome age Analysis analyzed Anti-spike antibody antibody level Antibody titre BNT162b2 BNT162b2 vaccine Care conducted coronavirus disease coronavirus disease-2019 Coronavirus-2 COVID-19 decrease dose Factor female females healthcare healthcare worker Healthcare workers hospital IgG IgG antibody Japanese negative correlation participant Participants preserved Prospective Study Protein Regression SARS-CoV-2 side Side effects tested the vaccine vaccination were infected [DOI] 10.1016/j.vaccine.2022.08.035 PMC 바로가기
Neutralising activity and antibody titre in 10 patients with breakthrough infections of the SARS-CoV-2 Omicron variant in Japan일본 SARS-CoV-2 오미크론 변이형 돌발성 감염 환자 10명의 중화 활성 및 항체 역가Article Published on 2022-09-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid Antibody titre Breakthrough infection breakthrough infections caused coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) dose elicited evade examined Immunity induce Japan Mutation Neutralising activity omicron Omicron variant Patient respiratory severe acute respiratory syndrome Coronavirus significantly lower Spike proteins the SARS-CoV-2 titre vaccination variant Wuhan strain [DOI] 10.1016/j.jiac.2022.04.018 PMC 바로가기 [Article Type] Article
Age- and sex-based changes in spike protein antibody status after SARS-CoV-2 vaccination and effect of past-infection in healthcare workers in OsakaArticle Published on 2022-08-262022-11-15 Journal: BMC Infectious Diseases [Category] SARS, 진단, [키워드] age Age group All participant antibody antibody status Antibody titre assays association Blood changes in different time point examined follow-up time healthcare worker investigated men not different nucleocapsid protein Nucleocapsid protein antibody participant Peripheral blood positive positive correlation Protein provided reduction in SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 vaccination second vaccination Seven Sex shown significant negative correlation significantly higher spike Spike protein Spike protein antibody. t-test titre vaccination were assessed women Yao [DOI] 10.1186/s12879-022-07695-7 PMC 바로가기
The effect of needle length and skin to deltoid muscle distance in adults receiving an mRNA COVID-19 vaccinemRNA COVID-19 백신을 접종받는 성인에서 바늘 길이와 피부에서 삼각근까지의 거리가 미치는 영향Observational Study Published on 2022-08-052022-09-12 Journal: Vaccine [Category] MERS, 임상, 진단, [키워드] administration Adults age antibody Antibody Response Antibody titre Blood blood sample BMI body mass index collected comparable COVID COVID-19 COVID-19 vaccine Deltoid muscle dose eligible adult Finger prick Follow-up group groups identify immunisation injection intramuscular Intramuscular injection mRNA mRNA vaccines needle Needle length no significant difference participant Participants Primary outcome proportion receiving required sensitivity specificity vaccination Vaccine [DOI] 10.1016/j.vaccine.2022.06.070 PMC 바로가기 [Article Type] Observational Study
Effects of cardiopulmonary bypass on immunoglobulin G antibody titres after SARS-CoV2 vaccinationObservational Study Published on 2022-08-032022-10-05 Journal: Interactive cardiovascular and thoracic surgery [Category] SARS, 임상, 진단, [키워드] acute respiratory syndrome antibody Antibody titre BNT162b2 calculated Cardiopulmonary cardiopulmonary bypass cardiovascular disease coronavirus Coronavirus disease 2019 decrease disease Effect effective group IgG IgG antibody Immunoglobulin Infection investigated Moderna mRNA vaccine mRNA-1273 Patient Pfizer/BioNTech preoperative preserved prospective observational study required SARS-CoV2 severe acute respiratory syndrome coronavirus 2 significantly significantly lower surgical the receptor-binding domain titre U/mL vaccination vaccination schedule Vaccine was measured while [DOI] 10.1093/icvts/ivac123 PMC 바로가기 [Article Type] Observational Study
Three-month follow-up of durability of response to the third dose of the SARS-CoV-2 BNT162b2 vaccine in adults aged 60 years and older: a prospective cohort study60세 이상 성인에서 SARS-CoV-2 BNT162b2 백신 3차 접종에 대한 반응 지속성 3개월 추적: 전향적 코호트 연구Article Published on 2022-08-022022-09-12 Journal: BMJ Open [Category] Coronavirus, SARS, 진단, [키워드] Adverse adverse event Analysis anti-spike IgG level antibody Antibody titre arbitrary unit blood sample BNT162b2 BNT162b2 vaccine CFS clinical cohort study concerning correlated COVID-19 COVID-19 infection defined dose Epidemiology evaluate evaluated events Follow-up healthy IgG IgG level immunology IQR median median age multivariable analysis neutralising neutralising antibody Older participant Patient Prospective prospective cohort study remained reported scale secondary outcome seropositive significantly the SARS-CoV-2 titre titres Vaccine [DOI] 10.1136/bmjopen-2022-061584 PMC 바로가기 [Article Type] Article