Flavonoids as a therapeutical option for the treatment of thrombotic complications associated with COVID-19Review Published on 2023-03-012023-07-11 Journal: Phytotherapy research : PTR [Category] COVID19(2023년), [키워드] Anticoagulant antiplatelet COVID-19 fibrinolytic flavonoids thrombosis. [DOI] 10.1002/ptr.7700 PMC 바로가기 [Article Type] Review
DNA damage in peripheral blood lymphocytes of severely ill COVID-19 patients in relation to inflammatory markers and parameters of hemostasisArticle Published on 2022-10-262022-11-15 Journal: Mutagenesis [Category] 바이오마커, 치료제, [키워드] activated Analysis Antibiotics Anticoagulant antiviral therapy applied Bearing biochemical C-reactive protein (CRP Chest chest X-ray Concentration contribute control subjects Corticosteroid COVID-19 COVID-19 patient COVID-19 patients demonstrated DNA DNA damage female Female patients Genetic Genome genotoxic healthy control healthy controls hematological parameters Hemostasis hemostasis abnormalities hospitalized COVID-19 patient IL-6 indicated Inflammation Inflammation. Inflammatory marker Laboratory laboratory parameter Laboratory parameters leukocyte lymphocyte neutrophil parameter performed peripheral blood lymphocyte Platelet positive positive correlation positively correlated procalcitonin reagent shown significantly significantly higher smoking statistically study population subjects therapy variety viral infections was measured X ray [DOI] 10.1093/mutage/geac011 PMC 바로가기
Antithrombin as Therapeutic Intervention against Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation: Lessons Learned from COVID-19-Associated CoagulopathyArticle Published on 2022-10-182022-11-15 Journal: International Journal of Molecular Sciences [Category] 바이오마커, [키워드] activity Anticoagulant Anticoagulants Antithrombin benefit Biomarker Coagulopathies Coagulopathy Combination contributed COVID-19 deficiency differential diagnosis Disseminated intravascular coagulation Establishing Evidence heterogeneous population Intervention lesson Pathogenesis recent Research Scoring scoring system Sepsis sepsis patient sepsis. significantly specific treatment Treatment [DOI] 10.3390/ijms232012474 PMC 바로가기
Anticoagulants as Potential SARS-CoV-2 Mpro Inhibitors for COVID-19 Patients: In Vitro, Molecular Docking, Molecular Dynamics, DFT, and SAR StudiesArticle Published on 2022-10-132022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] addition Anticoagulant Anticoagulants carried Compound compounds conducted COVID-19 cytotoxicity demonstrated drug Dynamics eligible enzyme highest highest binding affinity Idraparinux in silico in silico approaches in vitro in vitro. inhibitory inhibitory activity inhibitory concentration intrinsic investigated M pro molecular molecular docking MPro MTT performed Potential protease reference standard SAR SARS-CoV-2 SARS-CoV-2 Mpro screened sodium the SARS-CoV-2 thermodynamic [DOI] 10.3390/ijms232012235 PMC 바로가기
The current status of thrombosis and anticoagulation therapy in patients with COVID-19 in Japan: From the CLOT-COVID studyObservational Study Published on 2022-10-012022-10-05 Journal: Journal of cardiology [Category] COVID19(2023년), SARS, 임상, [키워드] Anticoagulant Anticoagulants anticoagulation Asian bleeding Computed tomography coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection diagnosed with COVID-19 died disease dose enrolled hospital Hospitalization hospitalized patient incidence Japan Major management Mild Moderate COVID-19 multicenter cohort study occurred Patient patients with COVID-19 pharmacological Pneumonia polymerase chain positive proportion Respiratory failure retrospective severe COVID-19 severity the patient therapy Thromboprophylaxis thrombosis thrombosis. unmet need Venous Thromboembolism with COVID-19 [DOI] 10.1016/j.jjcc.2022.03.015 PMC 바로가기 [Article Type] Observational Study
Thrombosis risk assessment in patients with congenital thrombophilia during COVID – 19 infectionResearch article Published on 2022-10-012022-10-05 Journal: Thrombosis research [Category] 변종, 유전자 메커니즘, 진단, [키워드] absence ACAnticoagulants addition adjusted age Anticoagulant Anticoagulants Antithrombin Antithrombotic association ATAntithrombin BMIbody mass index body mass index case-control study changes in clinical picture Comorbidities Comorbidity comparable Computed tomography Confirmed COVID-19 infection contribute Corona Virus Disease COVID COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients COVIDCorona Virus Disease Critical CTComputed Tomography D-dimer D-dimer level Deep venous thrombosis Diagnosis Direct oral anticoagulant disease DOACDirect Oral Anticoagulant DVTDeep Venous Thrombosis dysfunction evaluate Factor V Leiden factor VIII FEUFibrinogen Equivalent Fibrinogen Equivalent FII G20210AProthrombin mutation Final FV LeidenFactor V Leiden FVIII FVIIIFactor VIII genetic defect HBSHeparin Binding Site Heparin Binding Site individual Infection LMWHlow molecular weight heparin low molecular weight heparin Mild Odds ratio OROdds Ratio outcome parameter Patient patient group PCR/RFLPpolymerase chain reaction/restriction fragment length polymorphism PEPulmonary Embolism polymerase chain reaction/restriction fragment length polymorphism Prophylaxis Prothrombin mutation Pulmonary embolism receive Result risk risk of COVID-19 serious complication severe COVID-19 significantly significantly increased symptomatic thrombosis thrombotic thrombotic complication thrombotic event Thrombotic events Treatment Unusual Thrombosis UTUnusual Thrombosis Venous Thromboembolism vitamin K antagonist VKAVitamin K antagonist VTEVenous Thromboembolism was performed [DOI] 10.1016/j.thromres.2022.08.020 [Article Type] Research article
Management of Cerebral Venous Thrombosis Due to Adenoviral COVID-19 VaccinationArticle Published on 2022-10-012022-11-15 Journal: Annals of neurology [Category] COVID19(2023년), SARS, 진단, [키워드] 95% CI 95% confidence interval adenovirus-based adjusted adjusted odds ratio administration adverse effect analyzed ANN Anticoagulant Anticoagulants association autoimmune pathogenesis avoidance caused cerebral country COVID-19 diagnosed evaluate had no heparin hospital immune immunomodulation International Intravenous immunoglobulin lower mortality Mortality Patient Platelet recommendation reducing mortality SARS-CoV-2 SARS-CoV-2 vaccination significantly statistically significant the patient thrombotic treated Treatment used data Vaccines Venous thrombosis [DOI] 10.1002/ana.26431 PMC 바로가기
Consecutive central and branch retinal vein occlusions in the same eye of a young healthy COVID-19 patient: A unique case reportCase report Published on 2022-09-012022-10-05 Journal: American Journal of Ophthalmology Case Reports [Category] 바이오마커, [키워드] Anti-vascular endothelial growth factor Anticoagulant Aspirin branch retinal vein occlusion Case report Central retinal vein occlusion Complete coronavirus disease correlated COVID-19 decrease demonstrated Diagnosis diagnosis of COVID-19 edema endothelial etiology Fluorescein Follow-up growth factor had no healthy hemorrhages identify Infection intravitreal knowledge low-dose macular edema observation occurred Patient Prophylaxis retinal vein risk factor tomography Treatment undergo unique visual acuity was done was increased while with COVID-19 [DOI] 10.1016/j.ajoc.2022.101669 [Article Type] Case report
Chronic biopsy proven post-COVID myoendocarditis with SARS-Cov-2 persistence and high level of antiheart antibodiesArticle Published on 2022-09-012022-11-16 Journal: Clinical Cardiology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Admission Analysis antibody Anticoagulant antiheart antibodies association Atherosclerosis Autoimmune average biopsy proven CD20 CD3 CD45 CD68 characterized chronic chronic heart failure Clinical sign Combination congestive heart failure Coronary coronavirus COVID-19 diagnosed Diagnosis diagnosis of COVID-19 edema Ejection fraction EMB Endocarditis Endomyocardial biopsy Endothelium eosinophilic myocarditis heart IgG IHC immune infective lymphocytic myocarditis Macrophage male mechanism Morphological Myocardial myocarditis New York nine nucleocapsid antigens Patient patients persistence polymerase chain post-COVID endocarditis post-COVID myocarditis RNA SARS-CoV-2 Seroconversion Symptom therapy thrombosis Treatment ventricular viral infection viral persistence viral persistence. was obtained [DOI] 10.1002/clc.23886 PMC 바로가기
Dysregulated miRNAs network in the critical COVID-19: An important clue for uncontrolled immunothrombosis/thromboinflammation중요한 COVID-19에서 조절되지 않는 miRNA 네트워크: 통제되지 않는 면역혈전증/혈전염증에 대한 중요한 단서Review Published on 2022-09-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] accompanied activated Activation adenine affecting anti-inflammatory factors Anticoagulant cause clinical complication Coagulation Coagulation system complement complement system Complication components conserved coronavirus disease Coronavirus disease 2019 COVID-19 Critical Cytokine storm Defensive mechanism deviation diffusion Effect expression expression level facilitate Factor function Genetic higher risk homeostasis hyperinflammation immune immunothrombosis incidence Interaction involved life-threatening mechanism microRNA MicroRNAs miRNA miRNAs miRNAs-based therapy. molecules Mortality NADPH nicotinamide nicotinamide adenine dinucleotide Nicotinamide adenine dinucleotide phosphate Non-coding RNAs nucleotide oxygen Pathogens Patient phosphate reactive oxygen species reactive oxygen specy reduction response restrict SARS-CoV-2 severe complications therapeutic approach therapy Thromboinflammation thrombotic underlie vicious cycle [DOI] 10.1016/j.intimp.2022.109040 PMC 바로가기 [Article Type] Review