Omics approaches open new horizons in major depressive disorder: from biomarkers to precision medicinePsychiatry Review Published on 2024-06-132024-09-05 Journal: Frontiers in Psychiatry [Category] update2024, [키워드] antidepressant Biomarkers major depressive disorder precision medicine system biomedicine [DOI] 10.3389/fpsyt.2024.1422939 PMC 바로가기 [Article Type] Psychiatry Review
A systematic review and meta-analysis, investigating dose and time of fluvoxamine treatment efficacy for COVID-19 clinical deterioration, death, and Long-COVID complicationsArticle Published on 2024-06-122024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] (E)‐5‐methoxy‐1‐[4‐(trifluoromethyl)phenyl]pentan‐1‐one O‐2‐aminoethyl oxime) antidepressant coronavirus Disease prevention Drug repurposing Drug safety Infectious diseases Neurochemistry Neurological disorders pandemic Pharmacology Psychiatric disorders public health Respiratory tract diseases SARS-CoV-2 Sigma-1 receptor (σ1R) Target identification Therapeutics viral infection [DOI] 10.1038/s41598-024-64260-9 PMC 바로가기 [Article Type] Article
Preclinical and clinical pharmacology of brexanolone (allopregnanolone) for postpartum depression: a landmark journey from concept to clinic in neurosteroid replacement therapyarticle Published on 2023-08-112024-09-05 Journal: Psychopharmacology [Category] update2024, [키워드] Allopregnanolone antidepressant Brexanolone GABA-A receptor Postpartum depression [DOI] 10.1007/s00213-023-06427-2 PMC 바로가기 [Article Type] article
Selective serotonin reuptake inhibitor (SSRI) antidepressants reduce COVID-19 infection: prospects for useArticle Published on 2022-10-012022-11-15 Journal: European Journal of Clinical Pharmacology [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] absence antidepressant antidepressants antiviral drug approved article benefit Care Clinical outcome clinical trial coronavirus COVID COVID-19 database death decrease drug effort Hospitalization Infection infections information inhibit inhibitor Intensive intubation methodological flaws Mild-to-moderate mortality rates Novel coronavirus pandemic patients receptor Redirection reduce reported repositioning Repositioning. Research risk SARS-CoV-2 SciELO selective Serotonin shown specific treatment therapeutic intervention Toxicity treat Treatment viral titer was performed [DOI] 10.1007/s00228-022-03372-5 PMC 바로가기
Association between antidepressant use and ED or hospital visits in outpatients with SARS-CoV-2 Research Published on 2022-08-222022-10-05 Journal: Translational Psychiatry [Category] SARS, 신약개발, 치료법, 치료제, [키워드] 95% CI adjusted odds ratio ambulatory patient antidepressant association Clinical deterioration COVID-19 daily dose dose-dependent manner drug Effect exploratory functional hospital Hospital admission incidence less Logistic regression analysis medication outcome Outpatient Patient patients hospitalized performed positive reduced retrospective cohort study SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positive patients SARS-CoV-2 test secondary Secondary analyses selective serotonin reuptake inhibitor Support tested with COVID-19 [DOI] 10.1038/s41398-022-02109-3 [Article Type] Research
Antidepressants promote the spread of extracellular antibiotic resistance genes via transformation Research Published on 2022-07-282022-10-05 Journal: ISME Communications [Category] 변종, 유전자 메커니즘, [키워드] accelerate Acinetobacter Antibiotic resistance antibiotic resistance gene antidepressant antimicrobial Arg ARGs ATP Bupropion cell membrane clinically Concentration demonstrated dissemination Duloxetine Extracellular Fluoxetine Gut Health Human increasingly Interaction microbial community potential risk promote reactive oxygen species Result sertraline significantly SOS response Spread stimulated Stress Transcription transfer translation [DOI] 10.1038/s43705-022-00147-y [Article Type] Research
Robust antiviral activity of commonly prescribed antidepressants against emerging coronaviruses: in vitro and in silico drug repurposing studies신종 코로나바이러스에 대해 일반적으로 처방되는 항우울제의 강력한 항바이러스 활성: 시험관 내 및 실리코 약물 용도 변경 연구Article Published on 2022-07-282022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] activities activity amitriptyline anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Anti-viral antidepressant antidepressants antiviral activity clinical trials coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Depression disorder disorders drug eating disorders effective Efficacy eight evaluated FDA-approved drug FDA-approved drugs FIVE imipramine in silico in vitro in vivo M pro MERS MERS-CoV migraine molecular docking studies Molecular docking study neuralgia pandemic Paroxetine Patient performed Prophylaxis protease reported symptom Result SARS-CoV-2 sertraline suggested symptomatic and asymptomatic symptoms of depression treating COVID-19 Treatment [DOI] 10.1038/s41598-022-17082-6 PMC 바로가기 [Article Type] Article
Antidepressants for COVID-19: A systematic reviewReview article Published on 2022-06-012022-10-05 Journal: Journal of affective disorders [Category] 임상, [키워드] antidepressant antidepressants Chinese Clinical deterioration Cochrane Library coronavirus disease COVID-19 COVID-19 patient COVID-19 patients determine dropout rate Efficacy and safety Evidence examined fluvoxamine hospitalisation journal Mortality objective patients with COVID-19 Placebo prospective cohort study PsycINFO randomized clinical trial RCT RCTs reduced reducing researcher Result retrospective Retrospective study risk supported systematic review Treatment was performed [DOI] 10.1016/j.jad.2022.03.059 [Article Type] Review article
Shedding light on the toxicity of SARS-CoV-2-derived peptide in non-target COVID-19 organisms: A study involving inbred and outbred mice비표적 COVID-19 유기체에서 SARS-CoV-2 유래 펩타이드의 독성에 대한 조명: 근친교배 및 근친교배 마우스를 대상으로 한 연구Article Published on 2022-05-012022-09-11 Journal: Neurotoxicology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] acetylcholinesterase activated administration alteration animals antidepressant antioxidant anxiolytic applied biochemical Biomarker Brain C57Bl/6 J mice catalase consequence COVID-19 demonstrated depressive dismutase dispersion Effect Environmental Toxicology evaluate evaluated Evidence evidence of exposure to Field test genetic profile greater homeostasis hydrogen hydrogen peroxide Impact Laboratory locomotor maintain male mammalian mechanism memory memory deficit mice natural environments open oxidative stress Pandemic COVID-19 PCA peptide Principal component principal component analysis Protein Proteins provide reactive reduction in Research response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 particle SARS-CoV-2 particles sensitivity shedding Spike protein Superoxide Superoxide Dismutase Swiss mice. the Spike the vaccine Therapeutic strategies therapeutic strategy Toxicity Viral [DOI] 10.1016/j.neuro.2022.03.012 PMC 바로가기 [Article Type] Article
Impact of COVID-19 Pandemic on the Use of Antidepressant and Antianxiety Pharmaceuticals as Well as Sick Leave in PolandCovid-19 Pandemic이 항우울제 및 항발성 제약의 사용 및 폴란드의 병가의 영향Article Published on 2022-02-142022-08-31 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), MERS, SARS, 치료제, [키워드] absence analyzed antianxiety antidepressant antidepressants Anxiety caused Clinical practice Consumption COVID-19 COVID-19 pandemic Depression Diagnosis Impact impacted Interrupted Measures medication mental condition mental health pandemic Patient pharmaceutical Pharmaceuticals physician Poland Psychiatric psychiatric patients reaction Research Sery sick leave significantly strain Stress time Treatment well Workplace [DOI] 10.3390/ijerph19042135 PMC 바로가기 [Article Type] Article