Antigenic strain diversity predicts different biogeographic patterns of maintenance and decline of antimalarial drug resistancearticle Published on 2024-02-282024-09-01 Journal: eLife [Category] 말라리아, [키워드] antigenic diversity disease modeling drug resistance Epidemiology global health Greater Mekong Subregion P. falciparum [Article Type] article
Epidemiological and virological surveillance of influenza viruses in China during 2020-20212020-2021년 동안 중국에서 인플루엔자 바이러스의 역학 및 바이러스 감시Article Published on 2022-06-292022-09-11 Journal: Infectious Diseases of Poverty [Category] COVID19(2023년), SARS, 치료제, [키워드] accompanied acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition analyses Analysis analyzed antigenic antigenic diversity Antiviral antiviral medication Antiviral medications B/Victoria lineage viruses caused Characteristics characterized China Chinese circulating collected component components conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic declined Diversity Epidemic epidemiological Epidemiology flu Genetic genetic diversity Hemisphere hospital Influenza influenza like illness Influenza virus influenza viruses inhibitors isolate Laboratory Lineage mainland molecular Mutation network neuraminidase inhibitor neuraminidase inhibitors Next-generation sequencing outbreak pandemic phenotypic Phylogenetic analysis preventive measure preventive measures reduced Region remained representing respiratory respiratory specimens respond SARS-CoV-2 Seasonal influenza sensitivity Sequencing severe acute respiratory syndrome Coronavirus specimen study period Surveillance susceptibility tested the vaccine unique Virological Virological. virus viruses was performed was used Winter [DOI] 10.1186/s40249-022-01002-x PMC 바로가기 [Article Type] Article
Bacteria-enabled oral delivery of a replicon-based mRNA vaccine candidate protects against ancestral and delta variant SARS-CoV-2레플리콘 기반 mRNA 백신 후보의 박테리아 지원 경구 전달은 조상 및 델타 변이형 SARS-CoV-2로부터 보호Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alphaviruses antibody antigenic diversity B.1.617.2 Bacteria Cellular immune response cellular immune responses clade contributed contributing to Coronavirus-2 COVID-19 cross-protective domain Efficacy epitope Epitopes Evolution feasible forest gene delivery hamster hamsters heptad repeat immune responses immunization immunized immunized mice Immunoglobulin lung Lungs mass vaccination membrane protein mRNA mRNA vaccine mucosal mucosal vaccine NAbs nasal Nasal cavity Neutralizing antibodies neutralizing antibody non-structural protein nsp13 offer oral Oral Immunization oral route Pneumonia principle PROTECT provide RBD Receptor binding domain recorded replicon-based respiratory Salmonella Salmonella-mediated SARS-CoV-2 secretory IgA SIgA the vaccine vaccination Vaccine vaccine efficacy variant variants Viral viral replication virus [DOI] 10.1016/j.ymthe.2022.01.042 PMC 바로가기 [Article Type] Article
An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concernResearch Articles Published on 2022-04-262022-10-04 Journal: Science Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 ACE2-binding site animal models antibody antigenic diversity antigenic site Beta concern conserved COVID-19 Cryo-electron microscopy Delta description domain effective epitope Evolution of SARS-CoV-2 experiments Gamma hamster Human monoclonal antibody hydrophobic residue Immune escape in vitro mice monoclonal antibody Mutation neutralization neutralization capacity Neutralizing activity omicron pandemic Prophylactic prophylactically Protective receptor binding site retained SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants site-directed mutagenesis target the S protein the spike protein therapeutic therapeutic activity VOCs [DOI] 10.1126/sciimmunol.abp9312 PMC 바로가기 [Article Type] Research Articles
A SARS-CoV-2 Nucleocapsid Variant that Affects Antigen Test Performance항원 테스트 성능에 영향을 미치는 SARS-CoV-2 뉴클레오캡시드 변이체Article Published on 2021-08-012022-09-11 Journal: Journal of Clinical Virology [Category] MERS, SARS, 변종, 진단, 치료기술, 치료법, [키워드] Abbott affecting analytical sensitivity Antigen antigen test antigenic diversity assays Card COVID-19 defined demonstrated diagnostic diagnostic test diagnostic tests diagnostics false False negative FDA Genome genomes global pandemic impacted isolate Laboratory lineages molecular molecular diagnostic tests Mutation mutations nucleocapsid nucleocapsid protein occurred pathogen performance positive Quidel SARS-CoV-2 SARS-CoV-2 nucleocapsid sensitivity Sofia 2 specimen Spike protein Test tested Testing the spike protein variant Variation variety Viral Viral load while Whole genome sequencing writing [DOI] 10.1016/j.jcv.2021.104900 PMC 바로가기 [Article Type] Article
The spike glycoprotein genes of porcine epidemic diarrhea viruses isolated in ChinaResearch Article Published on 2021-06-152022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] addition Affect Amino acid Analysis analyzed antigen drift antigenic diversity B cell epitope B cell epitopes benefit cause China circulating Complete contagious disease epidemic diarrhea full-length Genetic genetic diversity Genome Infection information linear occurred PEDV Phylogenetic analysis porcine epidemic diarrhea virus (PEDV) Protein Recombination recombination event reveal spike spike gene spike glycoprotein spike glycoprotein gene Spike protein supplementary material the spike protein Variation viral disease virulent virus [DOI] 10.1186/s13567-021-00954-6 PMC 바로가기 [Article Type] Research Article
ORF3a mutation associated with higher mortality rate in SARS-CoV-2 infectionOriginal Paper Published on 2020-10-262022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress acute respiratory syndrome affecting amino acid change antigenic diversity association B cell caused change chemokine Complete coronavirus country COVID-19 cytokine-related pathways epitope Extensive functional annotation Genetic variant Genome sequencing globe Host immune response in silico Jak-STAT leucine Modification Mortality mortality rate motif Mutation network analysis ORF3a ORF3a protein pathway Phosphorylation SARS-CoV-2 SARS-COV-2 infection Signal transduction syndrome [DOI] 10.1017/S0950268820002599 PMC 바로가기 [Article Type] Original Paper
A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severityArticle Published on 2020-09-172022-10-04 Journal: Nature Communications [Category] SARS, 유전자 메커니즘, [키워드] absence Abstract Affect antibodies antibody antibody immunity antibody kinetics Antibody mediated immunity Antibody Response antigenic diversity association caused coronavirus Coronaviruses COVID-19 outbreak cross-reactivity determine disease severity Endemic endemic human coronavirus Evidence future infection Illness severity immune response immune responses Immunopathogenesis individual Infection manuscript mediated immunity MERS-CoV other coronavirus PROTECT protective immunity provide Public health response Research SARS-CoV SARS-CoV-2 severity systematic review Transmission vaccination Viral host response viral infection while [DOI] 10.1038/s41467-020-18450-4 PMC 바로가기 [Article Type] Article
Effect of low complexity regions within the PvMSP3α block II on the tertiary structure of the protein and implications to immune escape mechanismsPvMSP3α 블록 II 내의 저복잡성 영역이 단백질의 3차 구조에 미치는 영향과 면역 회피 메커니즘에 대한 함의Research Article Published on 2019-03-272024-08-11 Journal: BMC Structural Biology [Category] 말라리아, [키워드] antigenic diversity immune evasion Low complexity regions Vaccine design [DOI] 10.1186/s12900-019-0104-0 PMC 바로가기 [Article Type] Research Article
Multiscale Immune Selection and the Transmission-Diversity Feedback in Antigenically Diverse Pathogen SystemsArticle Published on 2018-12-312024-09-09 Journal: Am Nat [Category] 말라리아, [키워드] antigenic diversity immune selection Individual-based model Plasmodium falciparum positive feedback recombination. PMC 바로가기