Advancement in the Antigenic Epitopes and Vaccine Adjuvants of African Swine Fever VirusReview Published on 2024-08-212024-09-05 Journal: Pathogens [Category] update2024, [키워드] African Swine Fever Virus antigenic epitope B-cell epitope T-cell epitope Vaccine adjuvants [DOI] 10.3390/pathogens13080706 PMC 바로가기 [Article Type] Review
Immunoinformatic approach for the construction of multi-epitopes vaccine against omicron COVID-19 variant오미크론 COVID-19 변이체에 대한 다중 에피토프 백신 구축을 위한 면역정보학적 접근Article Published on 2022-07-012022-09-11 Journal: Virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] added adjuvant antigenic antigenic epitope antigenic epitopes applied approach B cell epitope B cell epitopes B-cell B.1.1.529 CD4 CD8 chimeric Chimeric vaccine model codon optimization complexes computational tool computational tools concern construction country COVID-19 COVID-19 omicron variant effective epitope Epitopes expression Final flexible Health Organization help highly antigenic Host IFN-γ immune mechanism immunogenic in-silico increasingly inducer initiative linker MEV MHC-II molecular molecular docking molecular dynamics mutagenic N-terminal non-allergenic non-toxic omicron Omicron variant overlapping peptide peptide-based planet Protein reverse vaccinology SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 variant Scientific community Simulation spike Spike protein stability suggested T-cell T-cell epitopes TLR TLR2 TLR4 TLRs toxic treat unique vaccination Vaccine vaccine candidate variant VoC WHO World Health Organization [DOI] 10.1016/j.virol.2022.05.001 PMC 바로가기 [Article Type] Article
Omicron variant receptor-binding domain phylogenetics and molecular dynamics오미크론 변이체 수용체 결합 도메인 계통발생학 및 분자 역학Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] addition Alpha alpha and delta variants Amino acid analyses angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 receptor anticipated antigenic antigenic epitope antigenic epitopes antigenic site arithmetic mean Beta binding changes in Clustering conformation conserved COVID-19 Delta deviation domain epitope Epitopes evolutionary relationships expected FIVE fluctuation Gamma greater immune reactions investigated MD simulations molecular molecular dynamics Mutation mutations omicron Omicron variant other variants Phylogenetic Phylogenetic relationship phylogenetics predicted RBD RBD binding RBD mutation RBD of SARS-CoV-2 receptor Receptor-binding domain residue residues Root-mean-square deviation SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variant SARS-CoV-2 variants sequence significantly suggested surface area tested the receptor-binding domain the SARS-CoV-2 variant variants [DOI] 10.1016/j.compbiomed.2022.105633 PMC 바로가기 [Article Type] Article
Neutralizing Monoclonal Antibodies Inhibit SARS-CoV-2 Infection through Blocking Membrane Fusion중화 단일 클론 항체는 막 융합 차단을 통해 SARS-CoV-2 감염을 억제합니다Article Published on 2022-04-272022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Alpha antigenic epitope Antisera blocking cell membrane collected conserved COVID-19 therapeutics Delta Effectiveness epitope epitope peptide Epitopes Epsilon exhibited fusion Gamma immunized immunodominant Infection inhibit SARS-CoV-2 inhibited membrane membrane fusion mice MOST Mutation NAb NAbs Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody peptides Protein RBD RBD sequence RBD sequences Receptor binding Receptor binding domain reduced S protein S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants SARS-like coronaviruses sequence spike (S) protein the RBD the S protein the SARS-CoV-2 unique Vaccine Vaccines variants virus virus entry [DOI] 10.1128/spectrum.01814-21 PMC 바로가기 [Article Type] Article
Design of a multi-epitope-based peptide vaccine against the S and N proteins of SARS-COV-2 using immunoinformatics approachResearch Published on 2022-02-042022-11-01 Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19, [키워드] acquisition adjuvant adjuvants antigenic antigenic epitope antigenicity approach B cell B cell epitope C terminal cloned COVID-19 virus CTL develop E. coli epitope evaluated expression HTL identify immune response immunoinformatics Infection linker Mortality Multi-epitope Multi-epitope vaccine N protein non-allergenic non-toxic pandemic peptide predicted reduce Result SARS Coronavirus SARS-CoV-2 SARS-CoV-2 S protein selected supplementary material the vaccine three-dimensional structure Toxicity Vaccine vaccine construct were used [DOI] 10.1186/s43042-022-00224-w PMC 바로가기 [Article Type] Research
[Characterization of a monoclonal antibody against the hemagglutinin stem of H7N9 subtype avian influenza virus]Article Published on 2022-01-252023-06-22 Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology [Category] 조류인플루엔자, [키워드] antigenic epitope Avian influenza virus cross-reactivity hemagglutinin stem monoclonal antibody [DOI] 10.13345/j.cjb.210173
A Next-Generation Vaccine Candidate Using Alternative Epitopes to Protect against Wuhan and All Significant Mutant Variants of SARS-CoV-2: An Immunoinformatics ApproachOriginal Article Published on 2021-12-012022-10-28 Journal: Aging and Disease [Category] COVID-19, [키워드] added antigenic epitope applied approach B cell B.1.1.28 B.1.1.7 B.1.351 bioinformatics boost immunity candidate codon optimization computational tools country demonstrated develop epitope expression flexible host immune system identify immunoinformatics In silico cloning Interaction linker molecular molecular docking analysis multi-epitopes mutagenic mutant mutant variants N-terminal next-generation vaccine parameter peptide peptide vaccine peptide-based physicochemical property Region SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants second wave Significant stability T cell epitopes the vaccine Vaccine vaccine candidate vaccine construct variant variants variants of SARS-CoV-2 VoC were assessed were used Wuhan [DOI] 10.14336/AD.2021.0518 PMC 바로가기 [Article Type] Original Article
Next-Generation Bioinformatics Approaches and Resources for Coronavirus Vaccine Discovery and Development—A Perspective ReviewReview Published on 2021-07-222022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 3D structure acute respiratory syndrome antigenic epitope bioinformatics bioinformatics resources caused computational tool contagious coronavirus coronavirus strain coronavirus vaccine COVID-19 database death disease effective effort epitope experimental validation function Genome sequencing genomic globe immune response immunoinformatics in viral pandemic pathogen platform Protein researcher resource resources review SARS-CoV-2 Stage target the vaccine Vaccine vaccine construct valuable resource [DOI] 10.3390/vaccines9080812 PMC 바로가기 [Article Type] Review
Purification and characterization of the receptor‐binding domain of SARS‐CoV‐2 spike protein from Escherichia coliResearch Article Published on 2021-05-072022-10-31 Journal: Engineering in Life Sciences [Category] COVID-19, [키워드] ACE2 antigenic epitope binding characterized COVID‐19 COVID‐19 drug E. coli Escherichia coli expected expressed Flow glycosylation HEK293 cell Host host cell inhibitors lack low expression mammalian cell Neutralizing antibodies pandemic Protein protein expression purification purified RBD receptor‐binding domain responsible SARS‐CoV‐2 SARS‐CoV‐2 secondary structure severe respiratory disease spike Spike protein the vaccine Vaccines viral entry virus [DOI] 10.1002/elsc.202000106 PMC 바로가기 [Article Type] Research Article
Conformational Changes of the Receptor Binding Domain of SARS-CoV-2 Spike Protein and Prediction of a B-Cell Antigenic Epitope Using Structural DataArtificial Intelligence Published on 2021-03-252022-10-31 Journal: Frontiers in Artificial Intelligence [Category] COVID-19, [키워드] ACE2 binding addition antibody antigenic antigenic epitope antigenic epitopes approach B-cell binding caused change common cold virus common cold viruses Complete complex conformational conformational epitope Containing Coordinate COVID-19 defined Diagnosis diagnostic epitope identify identifying Infection Mortality mortality rate overlap predicted prediction Protein RBD RBD of SARS-CoV-2 RBD-ACE2 Receptor binding domain receptor binding domian receptor complex SARS-CoV SARS-CoV-2 SARS-CoV-2 virus SARS–CoV−2 spike Spike protein Spread Strategy the RBD the SARS-CoV-2 virus the spike protein therapy vaccine production viral infection Viral protein worldwide pandemic [DOI] 10.3389/frai.2021.630955 PMC 바로가기 [Article Type] Artificial Intelligence